Gene Page: SDCBP2
Summary ?
| GeneID | 27111 |
| Symbol | SDCBP2 |
| Synonyms | SITAC|SITAC18|ST-2 |
| Description | syndecan binding protein 2 |
| Reference | HGNC:HGNC:15756|Ensembl:ENSG00000125775|HPRD:18032|Vega:OTTHUMG00000031661 |
| Gene type | protein-coding |
| Map location | 20p13 |
| Sherlock p-value | 0.026 |
| Fetal beta | -1.614 |
| eGene | Cerebellar Hemisphere Cortex |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0008022 | protein C-terminus binding | IPI | 11152476 | |
| GO:0042803 | protein homodimerization activity | IDA | 11152476 | |
| GO:0046982 | protein heterodimerization activity | IPI | 11152476 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007399 | nervous system development | NAS | neurite (GO term level: 5) | 11152476 |
| GO:0007242 | intracellular signaling cascade | NAS | 11152476 | |
| GO:0046907 | intracellular transport | NAS | 11152476 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | IDA | 11152476 | |
| GO:0005886 | plasma membrane | IC | 11152476 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BEND7 | C10orf30 | FLJ40283 | MGC35247 | BEN domain containing 7 | Two-hybrid | BioGRID | 16189514 |
| C1orf35 | MGC4174 | MMTAG2 | chromosome 1 open reading frame 35 | Two-hybrid | BioGRID | 16189514 |
| DPPA2 | PESCRG1 | developmental pluripotency associated 2 | Two-hybrid | BioGRID | 16189514 |
| NFASC | DKFZp686P2250 | FLJ46866 | KIAA0756 | NF | NRCAML | neurofascin homolog (chicken) | - | HPRD | 11152476 |
| NRXN1 | DKFZp313P2036 | FLJ35941 | Hs.22998 | KIAA0578 | neurexin 1 | - | HPRD | 11152476 |
| PAFAH1B3 | - | platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa | Two-hybrid | BioGRID | 16189514 |
| PRR13 | DKFZp564J157 | FLJ23818 | TXR1 | proline rich 13 | Two-hybrid | BioGRID | 16189514 |
| SDCBP | MDA-9 | ST1 | SYCL | TACIP18 | syndecan binding protein (syntenin) | - | HPRD | 11152476 |
| SDCBP2 | FLJ12256 | SITAC18 | ST-2 | syndecan binding protein (syntenin) 2 | ST-2-beta interacts with ST-2-beta. | BIND | 11152476 |
| TIFA | MGC20791 | T2BP | T6BP | TIFAA | TRAF-interacting protein with forkhead-associated domain | Two-hybrid | BioGRID | 16189514 |
| ZCCHC17 | HSPC251 | PS1D | RP11-266K22.1 | pNO40 | zinc finger, CCHC domain containing 17 | Two-hybrid | BioGRID | 16189514 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN | 382 | 224 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS UP | 602 | 364 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
| FRASOR RESPONSE TO SERM OR FULVESTRANT DN | 50 | 29 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| GYORFFY MITOXANTRONE RESISTANCE | 57 | 35 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP | 259 | 159 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS UP | 135 | 96 | All SZGR 2.0 genes in this pathway |
| PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 | 403 | 240 | All SZGR 2.0 genes in this pathway |
| YANG BCL3 TARGETS UP | 364 | 236 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |
| ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | All SZGR 2.0 genes in this pathway |