Gene Page: PPIL6
Summary ?
| GeneID | 285755 |
| Symbol | PPIL6 |
| Synonyms | PPIase|RSPH12|bA425D10.6|dJ919F19.1 |
| Description | peptidylprolyl isomerase like 6 |
| Reference | HGNC:HGNC:21557|Ensembl:ENSG00000185250|HPRD:15165|Vega:OTTHUMG00000036593 |
| Gene type | protein-coding |
| Map location | 6q21 |
| Pascal p-value | 0.402 |
| Fetal beta | 0.678 |
| eGene | Cerebellum Cortex Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| CV:PheWAS | Phenome-wide association studies (PheWAS) | 157 SNPs associated with schizophrenia | 1 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
CV:PheWAS
| SNP ID | Chromosome | Position | Allele | P | Function | Gene | Up/Down Distance |
|---|---|---|---|---|---|---|---|
| rs9487094 | 6 | 109742015 | null | 1.798 | PPIL6 | null |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg23978557 | 6 | 109760819 | PPIL6;SMPD2 | 1.941E-4 | 0.432 | 0.035 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7773095 | chr6 | 109727076 | PPIL6 | 285755 | 0.13 | cis | ||
| rs17070580 | chr6 | 109738713 | PPIL6 | 285755 | 0.11 | cis | ||
| rs2236582 | chr6 | 109765817 | PPIL6 | 285755 | 0.1 | cis | ||
| rs4241527 | chr3 | 24487304 | PPIL6 | 285755 | 0.16 | trans | ||
| rs4858617 | chr3 | 24487720 | PPIL6 | 285755 | 0.16 | trans | ||
| rs6897022 | chr5 | 40336545 | PPIL6 | 285755 | 0.05 | trans | ||
| rs9292776 | chr5 | 40437844 | PPIL6 | 285755 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IEA | - | |
| GO:0016853 | isomerase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006457 | protein folding | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SENGUPTA NASOPHARYNGEAL CARCINOMA DN | 349 | 157 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| MARIADASON RESPONSE TO BUTYRATE CURCUMIN SULINDAC TSA 8 | 16 | 7 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 | 473 | 224 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER DN | 238 | 145 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS UP | 295 | 155 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 UP | 140 | 81 | All SZGR 2.0 genes in this pathway |