Gene Page: GPX5

Summary ?
GeneID2880
SymbolGPX5
SynonymsHEL-S-75p
Descriptionglutathione peroxidase 5
ReferenceMIM:603435|HGNC:HGNC:4557|Ensembl:ENSG00000224586|HPRD:11941|Vega:OTTHUMG00000016307
Gene typeprotein-coding
Map location6p22.1
Pascal p-value2.633E-5

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.033 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SYT170.710.75
NXPH10.710.61
PNOC0.680.61
RAB3B0.680.52
GRM80.670.68
MARCH110.670.67
SCG20.660.68
EPHB30.660.62
CYB5610.660.61
PDGFB0.650.56
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CSRP2-0.36-0.27
FRMD4B-0.35-0.36
NEDD9-0.35-0.37
ZEB2-0.34-0.31
SH2D2A-0.34-0.44
POU3F2-0.34-0.28
SLA-0.33-0.10
FOXG1B-0.33-0.24
VASH2-0.33-0.18
CARHSP1-0.33-0.42

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004602glutathione peroxidase activityIEA-
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006979response to oxidative stressIEA-
GO:0006629lipid metabolic processNAS9639555 
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLUTATHIONE METABOLISM 5034All SZGR 2.0 genes in this pathway
KEGG ARACHIDONIC ACID METABOLISM 5836All SZGR 2.0 genes in this pathway
HOUSTIS ROS 3629All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 9071All SZGR 2.0 genes in this pathway
DE YY1 TARGETS UP 2014All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway