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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: GRIA4

Summary

GeneID

2893

Symbol

GRIA4

Synonyms

GLUR4|GLUR4C|GLURD

Description

glutamate receptor, ionotrophic, AMPA 4

Locus tag

Gene type

protein-coding

Map location

11q22

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

GSMA_I

genome scan meta-analysis

Psr: 0.006

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 4

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0047

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004970

ionotropic glutamate receptor activity

IEA

glutamate (GO term level: 7)

GO:0005234

extracellular-glutamate-gated ion channel activity

IEA

glutamate (GO term level: 11)

GO:0004872

receptor activity

IEA

GO:0005216

ion channel activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007215

glutamate signaling pathway

TAS

glutamate (GO term level: 7)

8589990

GO:0006811

ion transport

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0045211

postsynaptic membrane

IEA

Synap, Neurotransmitter (GO term level: 5)

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0016021

integral to membrane

IEA

GO:0005886

plasma membrane

TAS

8589990

GO:0030054

cell junction

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CACNG2	MGC138502 \| MGC138504	calcium channel, voltage-dependent, gamma subunit 2	Affinity Capture-Western Co-fractionation	BioGRID	11140673
EPB41L1	4.1N \| DKFZp686H17242 \| KIAA0338 \| MGC11072	erythrocyte membrane protein band 4.1-like 1	-	HPRD	12574408
GRIA1	GLUH1 \| GLUR1 \| GLURA \| HBGR1 \| MGC133252	glutamate receptor, ionotropic, AMPA 1	-	HPRD,BioGRID	9466455
GRIP1	GRIP	glutamate receptor interacting protein 1	Reconstituted Complex Two-hybrid	BioGRID	11891216
PICK1	MGC15204 \| PICK \| PRKCABP	protein interacting with PRKCA 1	Reconstituted Complex Two-hybrid	BioGRID	11891216
PRKCG	MGC57564 \| PKC-gamma \| PKCC \| PKCG \| SCA14	protein kinase C, gamma	-	HPRD,BioGRID	12471040
SDCBP	MDA-9 \| ST1 \| SYCL \| TACIP18	syndecan binding protein (syntenin)	-	HPRD,BioGRID	11891216

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	272	195	All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	186	155	All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM	279	221	All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL	137	110	All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS	28	23	All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	16	11	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS	37	32	All SZGR genes in this pathway
REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION	15	14	All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN	800	473	All SZGR genes in this pathway
SCHLESINGER_H3K27ME3_IN_NORMAL_AND_METHYLATED_IN_CANCER	28	21	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D	79	62	All SZGR genes in this pathway
LEIN_NEURON_MARKERS	69	45	All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_HCP_WITH_H3K27ME3	97	72	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	21	28	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	20	27	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	20	27	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-218	1527	1534	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367	657	663	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-26	1230	1236	m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	1230	1236	m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-28	2244	2250	m8	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-30-3p	570	576	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	570	576	m8	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-378	203	209	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-493-5p	911	917	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-505	2341	2347	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-542-3p	755	761	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.