Gene Page: GSPT1

Summary
GeneID  2935
Symbol  GSPT1
Synonyms  551G9.2|ETF3A|FLJ38048|FLJ39067|GST1|eRF3a
Description  G1 to S phase transition 1
See related  HGNC:4621|MIM:139259|Ensembl:ENSG00000103342|HPRD:00753|
Locus tag  -
Gene type  protein-coding
Map location  16p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0557 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AP000351.110.990.99
GSTTP10.950.95
SIRPB10.600.36
KCNT10.600.38
RHPN10.600.50
AC134878.10.600.29
C6orf270.600.33
MAP4K20.580.39
CTSA0.580.46
LYNX10.570.39
Top 10 negatively co-expressed genes
FAM107B-0.37-0.43
UBE2L6-0.36-0.39
BCL10-0.35-0.36
C10orf119-0.35-0.38
KCNRG-0.35-0.33
ZNF92-0.35-0.37
ZNF181-0.35-0.40
GNA13-0.35-0.42
AC079354.7-0.35-0.39
MLLT3-0.35-0.29
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003747translation release factor activityIMP15326224 
GO:0003924GTPase activityTAS15326224 
GO:0005515protein bindingIPI9620853 |9712840 |12489690 
GO:0005525GTP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleTAS2511002 
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTAS15326224 
GO:0006412translationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularNAS15326224 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BIRC2API1 | HIAP2 | Hiap-2 | MIHB | RNF48 | cIAP1baculoviral IAP repeat-containing 2-HPRD,BioGRID12865429 
BIRC3AIP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49baculoviral IAP repeat-containing 3-HPRD12865429 
ETF1D5S1995 | ERF | ERF1 | MGC111066 | RF1 | SUP45L1 | TB3-1eukaryotic translation termination factor 1-HPRD,BioGRID9712840 
PABPC1PAB1 | PABP | PABP1 | PABPC2 | PABPL1poly(A) binding protein, cytoplasmic 1-HPRD,BioGRID10358005 
RNASELDKFZp781D08126 | MGC104972 | MGC133329 | PRCA1 | RNS4ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)RNASEL (RNase L) interacts with GSPT1 (eRF3).BIND15908960 
XIAPAPI3 | BIRC4 | ILP1 | MIHA | XLP2X-linked inhibitor of apoptosis-HPRD,BioGRID12865429 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12827331Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1442531m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-272733m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-320149155m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-378*134140m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-4863023081Ahsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-5391531591Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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