Gene Page: ANAPC4
Summary ?
| GeneID | 29945 |
| Symbol | ANAPC4 |
| Synonyms | APC4 |
| Description | anaphase promoting complex subunit 4 |
| Reference | MIM:606947|HGNC:HGNC:19990|Ensembl:ENSG00000053900|HPRD:09505|Vega:OTTHUMG00000097753 |
| Gene type | protein-coding |
| Map location | 4p15.2 |
| Pascal p-value | 0.049 |
| Sherlock p-value | 9.711E-4 |
| Fetal beta | 0.426 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2745349 | chr6 | 127419833 | ANAPC4 | 29945 | 0.08 | trans | ||
| rs146672135 | 4 | 25326858 | ANAPC4 | ENSG00000053900.6 | 3.06694E-6 | 0.05 | -51977 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ANAPC1 | APC1 | MCPR | TSG24 | anaphase promoting complex subunit 1 | Affinity Capture-Western Co-purification Reconstituted Complex | BioGRID | 11076961 |12956947 |
| ANAPC10 | APC10 | DKFZp564L0562 | DOC1 | anaphase promoting complex subunit 10 | Affinity Capture-Western | BioGRID | 12956947 |
| ANAPC2 | APC2 | RP11-350O14.5 | anaphase promoting complex subunit 2 | Reconstituted Complex | BioGRID | 12956947 |
| ANAPC5 | APC5 | anaphase promoting complex subunit 5 | - | HPRD,BioGRID | 10922056 |
| ANAPC7 | APC7 | anaphase promoting complex subunit 7 | Affinity Capture-Western Reconstituted Complex | BioGRID | 12956947 |
| APC2 | APCL | adenomatosis polyposis coli 2 | Affinity Capture-Western | BioGRID | 12956947 |
| CDC16 | APC6 | cell division cycle 16 homolog (S. cerevisiae) | Affinity Capture-Western | BioGRID | 12956947 |
| CDC23 | APC8 | cell division cycle 23 homolog (S. cerevisiae) | Affinity Capture-Western | BioGRID | 12956947 |
| CDC27 | APC3 | CDC27Hs | D0S1430E | D17S978E | HNUC | cell division cycle 27 homolog (S. cerevisiae) | Affinity Capture-Western | BioGRID | 12956947 |
| CDH1 | Arc-1 | CD324 | CDHE | ECAD | LCAM | UVO | cadherin 1, type 1, E-cadherin (epithelial) | Reconstituted Complex | BioGRID | 12956947 |
| FZR1 | CDC20C | CDH1 | FZR | FZR2 | HCDH | HCDH1 | KIAA1242 | fizzy/cell division cycle 20 related 1 (Drosophila) | Reconstituted Complex | BioGRID | 12956947 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CELL CYCLE | 128 | 84 | All SZGR 2.0 genes in this pathway |
| KEGG OOCYTE MEIOSIS | 114 | 79 | All SZGR 2.0 genes in this pathway |
| KEGG UBIQUITIN MEDIATED PROTEOLYSIS | 138 | 98 | All SZGR 2.0 genes in this pathway |
| KEGG PROGESTERONE MEDIATED OOCYTE MATURATION | 86 | 59 | All SZGR 2.0 genes in this pathway |
| REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | 24 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE | 421 | 253 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE MITOTIC | 325 | 185 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE CHECKPOINTS | 124 | 70 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 85 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 72 | 38 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | 73 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 64 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B | 26 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | 22 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME PHOSPHORYLATION OF THE APC C | 23 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 251 | 156 | All SZGR 2.0 genes in this pathway |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 212 | 129 | All SZGR 2.0 genes in this pathway |
| REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | 28 | 12 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| WAESCH ANAPHASE PROMOTING COMPLEX | 12 | 7 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS | 212 | 121 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |