Gene Page: HBB

Summary
GeneID  3043
Symbol  HBB
Synonyms  CD113t-C
Description  hemoglobin, beta
See related  HGNC:4827|MIM:141900|Ensembl:ENSG00000188170|HPRD:00786|
Locus tag  -
Gene type  protein-coding
Map location  11p15.5
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0179 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
OXT1.000.08
AVP1.000.03
PMCH0.990.29
TMEM1900.980.22
TMEM1460.940.23
FMO30.94-0.16
FAM81B0.940.08
WDR380.930.20
CD360.930.05
STOML30.920.25
Top 10 negatively co-expressed genes
AC008073.2-0.090.09
CD163L1-0.08-0.12
FBXO32-0.080.02
NDRG1-0.080.02
MGLL-0.08-0.12
AC016910.1-0.08-0.08
RTN4RL2-0.070.05
FBXW7-0.07-0.15
TMEM110-0.07-0.04
KIF16B-0.07-0.09
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0005506iron ion bindingIEA-
GO:0005344oxygen transporter activityIEA-
GO:0005344oxygen transporter activityNAS1971109 |11747442 
GO:0019825oxygen bindingIDA11747442 
GO:0019825oxygen bindingIEA-
GO:0020037heme bindingIEA-
GO:0030492hemoglobin bindingIDA1512262 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008217regulation of blood pressureIEA-
GO:0008150biological_processND-
GO:0006810transportIEA-
GO:0015671oxygen transportIEA-
GO:0015671oxygen transportNAS11747442 
GO:0015671oxygen transportTAS1540659 
GO:0030185nitric oxide transportNAS8292032 
GO:0050880regulation of blood vessel sizeIEA-
GO:0045429positive regulation of nitric oxide biosynthetic processNAS7965120 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005833hemoglobin complexIEA-
GO:0005833hemoglobin complexNAS10588683 
GO:0005833hemoglobin complexTAS1540659 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
HBA1CD31 | MGC126895 | MGC126897hemoglobin, alpha 1Co-crystal Structure
Two-hybrid
BioGRID6644819 |16169070 
HBA2-hemoglobin, alpha 2-HPRD,BioGRID10930828 
HBBCD113t-Chemoglobin, beta-HPRD1512262 |6644819 
|6726807 
HBZ-hemoglobin, zeta-HPRD11747442 
HPBP | HP2-ALPHA-2 | HPA1S | MGC111141haptoglobin-HPRD,BioGRID7378053 
HPRA-259H10.2 | HPhaptoglobin-related proteinin vitroBioGRID7716520 
ORC2LORC2origin recognition complex, subunit 2-like (yeast)Orc2 interacts with beta-globin origin.BIND15910003 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaBeta-globin interacts with pol II.BIND15565158 
SELT-selenoprotein TTwo-hybridBioGRID16169070 
UPF3AHUPF3A | RENT3A | UPF3UPF3 regulator of nonsense transcripts homolog A (yeast)Protein-RNABioGRID11163187 
UPF3BHUPF3B | MRXS14 | RENT3B | UPF3XUPF3 regulator of nonsense transcripts homolog B (yeast)Protein-RNABioGRID11163187 
XRCC5FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIVX-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)Ku80 interacts with beta-globin origin.BIND15910003 
 


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