Gene Page: HLA-DQB2
Summary ?
| GeneID | 3120 |
| Symbol | HLA-DQB2 |
| Synonyms | HLA-DQB1|HLA-DXB |
| Description | major histocompatibility complex, class II, DQ beta 2 |
| Reference | MIM:615161|HGNC:HGNC:4945|Ensembl:ENSG00000232629|HPRD:09983|HPRD:09984|Vega:OTTHUMG00000031125 |
| Gene type | protein-coding |
| Map location | 6p21 |
| Pascal p-value | 5.941E-8 |
| Fetal beta | -1.634 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg11099901 | 6 | 32729659 | HLA-DQB2 | 2.38E-5 | 0.508 | 0.017 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7744001 | 6 | 32626086 | HLA-DQB2 | ENSG00000232629.4 | 4.706E-7 | 0.01 | 105225 | gtex_brain_ba24 |
| rs7744020 | 6 | 32626130 | HLA-DQB2 | ENSG00000232629.4 | 2.146E-7 | 0.01 | 105181 | gtex_brain_ba24 |
| rs35779483 | 6 | 32626702 | HLA-DQB2 | ENSG00000232629.4 | 2.141E-7 | 0.01 | 104609 | gtex_brain_ba24 |
| rs4713571 | 6 | 32626899 | HLA-DQB2 | ENSG00000232629.4 | 6.195E-8 | 0.01 | 104412 | gtex_brain_ba24 |
| rs36205178 | 6 | 32627938 | HLA-DQB2 | ENSG00000232629.4 | 4.527E-7 | 0.01 | 103373 | gtex_brain_ba24 |
| rs41270875 | 6 | 32628272 | HLA-DQB2 | ENSG00000232629.4 | 4.687E-7 | 0.01 | 103039 | gtex_brain_ba24 |
| rs41270887 | 6 | 32628722 | HLA-DQB2 | ENSG00000232629.4 | 4.647E-7 | 0.01 | 102589 | gtex_brain_ba24 |
| rs41270891 | 6 | 32628771 | HLA-DQB2 | ENSG00000232629.4 | 4.74E-7 | 0.01 | 102540 | gtex_brain_ba24 |
| rs34643393 | 6 | 32628921 | HLA-DQB2 | ENSG00000232629.4 | 3.774E-7 | 0.01 | 102390 | gtex_brain_ba24 |
| rs34644981 | 6 | 32628939 | HLA-DQB2 | ENSG00000232629.4 | 4.178E-7 | 0.01 | 102372 | gtex_brain_ba24 |
| rs9273764 | 6 | 32629425 | HLA-DQB2 | ENSG00000232629.4 | 4.199E-7 | 0.01 | 101886 | gtex_brain_ba24 |
| rs41270915 | 6 | 32629692 | HLA-DQB2 | ENSG00000232629.4 | 4.198E-7 | 0.01 | 101619 | gtex_brain_ba24 |
| . | 6 | 32631119 | HLA-DQB2 | ENSG00000232629.4 | 4.62E-7 | 0.01 | 100192 | gtex_brain_ba24 |
| rs1130375 | 6 | 32632820 | HLA-DQB2 | ENSG00000232629.4 | 4.793E-7 | 0.01 | 98491 | gtex_brain_ba24 |
| rs41263828 | 6 | 32632995 | HLA-DQB2 | ENSG00000232629.4 | 1.21E-6 | 0.01 | 98316 | gtex_brain_ba24 |
| rs41268314 | 6 | 32633082 | HLA-DQB2 | ENSG00000232629.4 | 2.74E-7 | 0.01 | 98229 | gtex_brain_ba24 |
| rs41268316 | 6 | 32633083 | HLA-DQB2 | ENSG00000232629.4 | 3.438E-7 | 0.01 | 98228 | gtex_brain_ba24 |
| rs41263829 | 6 | 32633118 | HLA-DQB2 | ENSG00000232629.4 | 5.69E-8 | 0.01 | 98193 | gtex_brain_ba24 |
| rs41263830 | 6 | 32633126 | HLA-DQB2 | ENSG00000232629.4 | 3.565E-7 | 0.01 | 98185 | gtex_brain_ba24 |
| rs41263836 | 6 | 32633462 | HLA-DQB2 | ENSG00000232629.4 | 2.317E-7 | 0.01 | 97849 | gtex_brain_ba24 |
| rs35915063 | 6 | 32633519 | HLA-DQB2 | ENSG00000232629.4 | 2.663E-7 | 0.01 | 97792 | gtex_brain_ba24 |
| rs41264344 | 6 | 32633640 | HLA-DQB2 | ENSG00000232629.4 | 1.207E-6 | 0.01 | 97671 | gtex_brain_ba24 |
| rs41264348 | 6 | 32633646 | HLA-DQB2 | ENSG00000232629.4 | 1.207E-6 | 0.01 | 97665 | gtex_brain_ba24 |
| rs41264356 | 6 | 32633854 | HLA-DQB2 | ENSG00000232629.4 | 2.261E-7 | 0.01 | 97457 | gtex_brain_ba24 |
| rs35353422 | 6 | 32633948 | HLA-DQB2 | ENSG00000232629.4 | 1.847E-7 | 0.01 | 97363 | gtex_brain_ba24 |
| rs2854260 | 6 | 32634074 | HLA-DQB2 | ENSG00000232629.4 | 2.659E-7 | 0.01 | 97237 | gtex_brain_ba24 |
| rs34297496 | 6 | 32634229 | HLA-DQB2 | ENSG00000232629.4 | 2.655E-7 | 0.01 | 97082 | gtex_brain_ba24 |
| rs41316208 | 6 | 32634899 | HLA-DQB2 | ENSG00000232629.4 | 2.565E-7 | 0.01 | 96412 | gtex_brain_ba24 |
| rs75801742 | 6 | 32634992 | HLA-DQB2 | ENSG00000232629.4 | 2.789E-7 | 0.01 | 96319 | gtex_brain_ba24 |
| rs76356512 | 6 | 32635046 | HLA-DQB2 | ENSG00000232629.4 | 2.619E-7 | 0.01 | 96265 | gtex_brain_ba24 |
| rs142650965 | 6 | 32635820 | HLA-DQB2 | ENSG00000232629.4 | 2.531E-7 | 0.01 | 95491 | gtex_brain_ba24 |
| rs9461792 | 6 | 32636495 | HLA-DQB2 | ENSG00000232629.4 | 4.408E-8 | 0.01 | 94816 | gtex_brain_ba24 |
| rs9469211 | 6 | 32636514 | HLA-DQB2 | ENSG00000232629.4 | 4.396E-8 | 0.01 | 94797 | gtex_brain_ba24 |
| rs28371205 | 6 | 32636693 | HLA-DQB2 | ENSG00000232629.4 | 1.104E-7 | 0.01 | 94618 | gtex_brain_ba24 |
| rs28371206 | 6 | 32636696 | HLA-DQB2 | ENSG00000232629.4 | 1.098E-7 | 0.01 | 94615 | gtex_brain_ba24 |
| rs28371207 | 6 | 32636701 | HLA-DQB2 | ENSG00000232629.4 | 1.105E-7 | 0.01 | 94610 | gtex_brain_ba24 |
| rs17211818 | 6 | 32636963 | HLA-DQB2 | ENSG00000232629.4 | 3.296E-7 | 0.01 | 94348 | gtex_brain_ba24 |
| rs1694133 | 6 | 32637015 | HLA-DQB2 | ENSG00000232629.4 | 9.872E-8 | 0.01 | 94296 | gtex_brain_ba24 |
| rs17211861 | 6 | 32637121 | HLA-DQB2 | ENSG00000232629.4 | 2.797E-7 | 0.01 | 94190 | gtex_brain_ba24 |
| rs17211868 | 6 | 32637135 | HLA-DQB2 | ENSG00000232629.4 | 8.457E-7 | 0.01 | 94176 | gtex_brain_ba24 |
| rs17205521 | 6 | 32637138 | HLA-DQB2 | ENSG00000232629.4 | 8.457E-7 | 0.01 | 94173 | gtex_brain_ba24 |
| rs17205528 | 6 | 32637158 | HLA-DQB2 | ENSG00000232629.4 | 7.243E-7 | 0.01 | 94153 | gtex_brain_ba24 |
| rs17211902 | 6 | 32637215 | HLA-DQB2 | ENSG00000232629.4 | 8.023E-7 | 0.01 | 94096 | gtex_brain_ba24 |
| rs17205563 | 6 | 32637261 | HLA-DQB2 | ENSG00000232629.4 | 8.039E-7 | 0.01 | 94050 | gtex_brain_ba24 |
| rs17205605 | 6 | 32637327 | HLA-DQB2 | ENSG00000232629.4 | 8.032E-7 | 0.01 | 93984 | gtex_brain_ba24 |
| rs17205647 | 6 | 32637418 | HLA-DQB2 | ENSG00000232629.4 | 3.405E-7 | 0.01 | 93893 | gtex_brain_ba24 |
| rs34400217 | 6 | 32637750 | HLA-DQB2 | ENSG00000232629.4 | 8.437E-7 | 0.01 | 93561 | gtex_brain_ba24 |
| rs35195457 | 6 | 32637833 | HLA-DQB2 | ENSG00000232629.4 | 8.225E-7 | 0.01 | 93478 | gtex_brain_ba24 |
| rs35402595 | 6 | 32637912 | HLA-DQB2 | ENSG00000232629.4 | 8.4E-7 | 0.01 | 93399 | gtex_brain_ba24 |
| rs41316211 | 6 | 32639909 | HLA-DQB2 | ENSG00000232629.4 | 1.089E-7 | 0.01 | 91402 | gtex_brain_ba24 |
| rs41316231 | 6 | 32642376 | HLA-DQB2 | ENSG00000232629.4 | 3.788E-7 | 0.01 | 88935 | gtex_brain_ba24 |
| rs17212223 | 6 | 32651540 | HLA-DQB2 | ENSG00000232629.4 | 5.665E-7 | 0.01 | 79771 | gtex_brain_ba24 |
| rs17212455 | 6 | 32652526 | HLA-DQB2 | ENSG00000232629.4 | 6.624E-7 | 0.01 | 78785 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SCHUETZ BREAST CANCER DUCTAL INVASIVE UP | 351 | 230 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BONE DN | 315 | 197 | All SZGR 2.0 genes in this pathway |
| GAURNIER PSMD4 TARGETS | 73 | 55 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |