Gene Page: APAF1

Summary
GeneID  317
Symbol  APAF1
Synonyms  CED4|DKFZp781B1145
Description  apoptotic peptidase activating factor 1
See related  HGNC:576|MIM:602233|Ensembl:ENSG00000120868|HPRD:03755|
Locus tag  -
Gene type  protein-coding
Map location  12q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AL117209.10.870.91
DLGAP40.860.89
SHANK20.850.88
ASTN10.840.86
NRG30.830.85
MGAT30.830.88
SEMA4F0.830.85
DAB2IP0.820.87
EIF4G10.820.86
SPTBN10.820.84
Top 10 negatively co-expressed genes
AF347015.21-0.60-0.65
AF347015.31-0.57-0.60
AL139819.3-0.57-0.62
C1orf54-0.56-0.67
MT-CO2-0.56-0.59
GNG11-0.56-0.61
AC021016.1-0.55-0.58
AF347015.8-0.55-0.57
AF347015.27-0.54-0.58
HIGD1B-0.54-0.57
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingTAS10383829 
GO:0005524ATP bindingIEA-
GO:0008656caspase activator activityNAS15009102 
GO:0042802identical protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)9753320 
GO:0001843neural tube closureIEA-
GO:0008635caspase activation via cytochrome cIDA9267021 
GO:0007275multicellular organismal developmentIEA-
GO:0042981regulation of apoptosisTAS10441496 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9267021 |9390557 |9922454 
GO:0005829cytosolTAS9267021 
GO:0005622intracellularIEA-
GO:0005625soluble fractionIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APIPAPIP2 | CGI-29 | MMRP19 | dJ179L10.2APAF1 interacting protein-HPRD,BioGRID15262985 
AVENPDCD12apoptosis, caspase activation inhibitor-HPRD,BioGRID10949025 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD,BioGRID9488720 |9539746 
BCL2L10BCL-B | Boo | Diva | MGC129810 | MGC129811BCL2-like 10 (apoptosis facilitator)-HPRD9829980 |9878060 
|10486928 
CASP4ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TXcaspase 4, apoptosis-related cysteine peptidase-HPRD,BioGRID9539746 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD,BioGRID9539746 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD,BioGRID9390557 |9488720 
APAF1 interacts with CASP9.BIND15829969 
-HPRD9390557 |9488720 
|9539746 |9837928 
|10376594 
CYCSCYC | HCScytochrome c, somatic-HPRD,BioGRID9267021|12147322 
FEM1BDKFZp451E0710 | FIAAfem-1 homolog b (C. elegans)-HPRD10764728 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1Affinity Capture-WesternBioGRID10934467 
HSPA1AFLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1Bheat shock 70kDa protein 1A-HPRD10934467 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4Affinity Capture-Western
Co-purification
Reconstituted Complex		BioGRID10934467 
NLRP1CARD7 | CLR17.1 | DEFCAP | DEFCAP-L/S | DKFZp586O1822 | KIAA0926 | NAC | NALP1 | PP1044 | SLEV1 | VAMAS1NLR family, pyrin domain containing 1-HPRD,BioGRID11113115 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128215221581Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-2721522158m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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