Gene Page: HNRNPK

Summary
GeneID  3190
Symbol  HNRNPK
Synonyms  CSBP|FLJ41122|HNRPK|TUNP
Description  heterogeneous nuclear ribonucleoprotein K
See related  HGNC:5044|MIM:600712|Ensembl:ENSG00000165119|HPRD:02834|
Locus tag  -
Gene type  protein-coding
Map location  9q21.32-q21.33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003723RNA bindingIEA-
GO:0003723RNA bindingTAS8107114 
GO:0005515protein bindingIPI12029088 |16713569 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
GO:0008380RNA splicingIEA-
GO:0007165signal transductionTAS16130169 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005634nucleusTAS8107114 |16130169 
GO:0005654nucleoplasmTAS1729596 
GO:0005681spliceosomeIEA-
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmTAS16130169 
GO:0030529ribonucleoprotein complexIEA-
GO:0030530heterogeneous nuclear ribonucleoprotein complexTAS8107114 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID9553145 
CNNM3ACDP3 | DKFZp434I1016 | FLJ20018cyclin M3Two-hybridBioGRID16189514 
CSKMGC117393c-src tyrosine kinase-HPRD,BioGRID12052863 
DDX1DBP-RB | UKVH5dDEAD (Asp-Glu-Ala-Asp) box polypeptide 1DDX1 interacts with hnRNP K.BIND12183465 
-HPRD,BioGRID12183465 
DIDO1BYE1 | C20orf158 | DATF1 | DIDO2 | DIDO3 | DIO-1 | DIO1 | DKFZp434P1115 | FLJ11265 | KIAA0333 | MGC16140 | dJ885L7.8death inducer-obliterator 1Two-hybridBioGRID16189514 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESFyn interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between Fyn from an unspecified source and human hnRNPK.BIND8810341 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2Two-hybridBioGRID16189514 
HMGB1DKFZp686A04236 | HMG1 | HMG3 | SBP-1high-mobility group box 1-HPRD,BioGRID11748221 
HMGB1 interacts with HNRPK (hnRNPK). This interaction was modelled on a demonstrated interaction between rat HMGB1 and human HNRPK (hnRNPK).BIND11748221 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein KReconstituted Complex
Two-hybrid
BioGRID10772858 |16189514 
HNRNPLFLJ35509 | HNRPL | P/OKcl.14 | hnRNP-Lheterogeneous nuclear ribonucleoprotein LhnRNP L interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between hnRNP K from an unspecified source and human hnRNP L.BIND10809782 
-HPRD,BioGRID10772858 
ITKEMT | LYK | MGC126257 | MGC126258 | PSCTK2IL2-inducible T-cell kinaseItk interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between mouse Itk and human hnRNPK.BIND8810341 
-HPRD,BioGRID8810341 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1Sam68 interacts with hnRNP KBIND12370808 
Sam68 interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between Sam68 from an unspecified source and human hnRNP K.BIND12370808 
-HPRD,BioGRID12370808 
KHDRBS2FLJ38664 | MGC26664 | SLM-1 | SLM1 | bA535F17.1KH domain containing, RNA binding, signal transduction associated 2Two-hybridBioGRID16189514 
KHDRBS3Etle | SALP | SLM-2 | SLM2 | T-STAR | TSTAR | etoileKH domain containing, RNA binding, signal transduction associated 3Two-hybridBioGRID16189514 
MATR3DKFZp686K0542 | DKFZp686K23100 | KIAA0723 | MGC9105matrin 3Two-hybridBioGRID16189514 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD11557983 
Two-hybridBioGRID16189514 
NPDC1CAB | CAB- | CAB-1 | CAB1 | DKFZp586J0523neural proliferation, differentiation and control, 1Two-hybridBioGRID16189514 
PCBP2HNRPE2 | MGC110998 | hnRNP-E2poly(rC) binding protein 2-HPRD,BioGRID10772858 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)p85 interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between p85 from an unspecified source and human hnRNPK.BIND8810341 
PRMT1ANM1 | HCP1 | HRMT1L2 | IR1B4protein arginine methyltransferase 1-HPRD,BioGRID12529443 
PTBP1HNRNP-I | HNRNPI | HNRPI | MGC10830 | MGC8461 | PTB | PTB-1 | PTB-T | PTB2 | PTB3 | PTB4 | pPTBpolypyrimidine tract binding protein 1Reconstituted Complex
Two-hybrid
BioGRID10772858 
QKIDKFZp586I0923 | Hqk | QK | QK1 | QK3quaking homolog, KH domain RNA binding (mouse)Two-hybridBioGRID16189514 
RBM41FLJ11016 | FLJ13670 | bB383K5.1RNA binding motif protein 41Two-hybridBioGRID16189514 
RBM42MGC10433RNA binding motif protein 42Two-hybridBioGRID16189514 
RBM7FLJ11153RNA binding motif protein 7Two-hybridBioGRID16189514 
RBMXHNRPG | RBMXP1 | RBMXRT | RNMX | hnRNP-GRNA binding motif protein, X-linkedTwo-hybridBioGRID16189514 
SAFBDKFZp779C1727 | HAP | HET | SAFB1scaffold attachment factor BhnRNP K interacts with SAFB. This interaction was modeled on a demonstrated interaction between mouse proteins.BIND10809782 
SFRS12DKFZp564B176 | MGC133045 | SRrp508 | SRrp86splicing factor, arginine/serine-rich 12-HPRD14559993 
SFRS3SRp20splicing factor, arginine/serine-rich 3SRp20 interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between hnRNP K from an unspecified source and human SRp20.BIND10809782 
SORBS3SCAM-1 | SCAM1 | SH3D4 | VINEXINsorbin and SH3 domain containing 3Two-hybridBioGRID16189514 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Src interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between Src from an unspecified source and human hnRNPK.BIND8810341 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID16189514 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID8051112 
YBX1BP-8 | CSDA2 | CSDB | DBPB | MDR-NF1 | MGC104858 | MGC110976 | MGC117250 | NSEP-1 | NSEP1 | YB-1 | YB1Y box binding protein 1YB-1 interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between human hnRNP K and murineYB-1.BIND10809782 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2066672m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-10153159m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-129-5p178184m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-1813813871Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-20515211Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-21675681m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-28536542m8hsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-3393203271A,m8hsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-384104110471Ahsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-409-3p6571m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-4501781841Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-5398979041A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-544377383m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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