Gene Page: HSD3B2

Summary ?
GeneID3284
SymbolHSD3B2
SynonymsHSD3B|HSDB|SDR11E2
Descriptionhydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
ReferenceMIM:613890|HGNC:HGNC:5218|Ensembl:ENSG00000203859|HPRD:01941|Vega:OTTHUMG00000012526
Gene typeprotein-coding
Map location1p13.1
Pascal p-value0.304
Fetal beta-0.03

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0235 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HSPA1A0.980.75
DNAJB10.920.68
HSPA60.910.62
G0S20.800.25
BAG30.770.27
AL031847.10.650.11
ACRC0.610.18
HSPB10.600.25
SERPINH10.550.46
GPR840.540.23
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MFSD5-0.220.01
C20orf160-0.21-0.22
CDC42EP2-0.21-0.05
CLEC14A-0.20-0.17
MYLK2-0.19-0.13
LTC4S-0.19-0.36
AF205589.2-0.19-0.15
ACVRL1-0.19-0.02
CMTM8-0.19-0.34
C19orf39-0.19-0.11

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityIDA1944309 
GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityIEA-
GO:0005488bindingIEA-
GO:0004769steroid delta-isomerase activityIDA1944309 
GO:0016853isomerase activityIEA-
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008152metabolic processIEA-
GO:0006700C21-steroid hormone biosynthetic processIEA-
GO:0006694steroid biosynthetic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeISS-
GO:0005739mitochondrionIEA-
GO:0005743mitochondrial inner membraneISS-
GO:0005758mitochondrial intermembrane spaceISS-
GO:0005783endoplasmic reticulumNAS1944309 
GO:0016020membraneIEA-
GO:0016021integral to membraneNAS1944309 
GO:0030868smooth endoplasmic reticulum membraneISS-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG STEROID HORMONE BIOSYNTHESIS 5530All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D 3523All SZGR 2.0 genes in this pathway
REACTOME ANDROGEN BIOSYNTHESIS 108All SZGR 2.0 genes in this pathway
REACTOME STEROID HORMONES 2921All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR MARKERS DN 2014All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2 153102All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 6643All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 9159All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 9058All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR DN 3720All SZGR 2.0 genes in this pathway