Gene Page: HSD3B2
Summary ?
GeneID | 3284 |
Symbol | HSD3B2 |
Synonyms | HSD3B|HSDB|SDR11E2 |
Description | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
Reference | MIM:613890|HGNC:HGNC:5218|Ensembl:ENSG00000203859|HPRD:01941|Vega:OTTHUMG00000012526 |
Gene type | protein-coding |
Map location | 1p13.1 |
Pascal p-value | 0.304 |
Fetal beta | -0.03 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
CV:PGCnp | Genome-wide Association Study | GWAS | |
GSMA_I | Genome scan meta-analysis | Psr: 0.0235 | |
GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.00814 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
HSPA1A | 0.98 | 0.75 |
DNAJB1 | 0.92 | 0.68 |
HSPA6 | 0.91 | 0.62 |
G0S2 | 0.80 | 0.25 |
BAG3 | 0.77 | 0.27 |
AL031847.1 | 0.65 | 0.11 |
ACRC | 0.61 | 0.18 |
HSPB1 | 0.60 | 0.25 |
SERPINH1 | 0.55 | 0.46 |
GPR84 | 0.54 | 0.23 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
MFSD5 | -0.22 | 0.01 |
C20orf160 | -0.21 | -0.22 |
CDC42EP2 | -0.21 | -0.05 |
CLEC14A | -0.20 | -0.17 |
MYLK2 | -0.19 | -0.13 |
LTC4S | -0.19 | -0.36 |
AF205589.2 | -0.19 | -0.15 |
ACVRL1 | -0.19 | -0.02 |
CMTM8 | -0.19 | -0.34 |
C19orf39 | -0.19 | -0.11 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | IDA | 1944309 | |
GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | IEA | - | |
GO:0005488 | binding | IEA | - | |
GO:0004769 | steroid delta-isomerase activity | IDA | 1944309 | |
GO:0016853 | isomerase activity | IEA | - | |
GO:0016491 | oxidoreductase activity | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0008152 | metabolic process | IEA | - | |
GO:0006700 | C21-steroid hormone biosynthetic process | IEA | - | |
GO:0006694 | steroid biosynthetic process | IEA | - | |
GO:0055114 | oxidation reduction | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005792 | microsome | ISS | - | |
GO:0005739 | mitochondrion | IEA | - | |
GO:0005743 | mitochondrial inner membrane | ISS | - | |
GO:0005758 | mitochondrial intermembrane space | ISS | - | |
GO:0005783 | endoplasmic reticulum | NAS | 1944309 | |
GO:0016020 | membrane | IEA | - | |
GO:0016021 | integral to membrane | NAS | 1944309 | |
GO:0030868 | smooth endoplasmic reticulum membrane | ISS | - |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG STEROID HORMONE BIOSYNTHESIS | 55 | 30 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | 35 | 23 | All SZGR 2.0 genes in this pathway |
REACTOME ANDROGEN BIOSYNTHESIS | 10 | 8 | All SZGR 2.0 genes in this pathway |
REACTOME STEROID HORMONES | 29 | 21 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
WEST ADRENOCORTICAL TUMOR MARKERS DN | 20 | 14 | All SZGR 2.0 genes in this pathway |
SABATES COLORECTAL ADENOMA DN | 291 | 176 | All SZGR 2.0 genes in this pathway |
SHETH LIVER CANCER VS TXNIP LOSS PAM2 | 153 | 102 | All SZGR 2.0 genes in this pathway |
LEE LIVER CANCER CIPROFIBRATE DN | 66 | 43 | All SZGR 2.0 genes in this pathway |
LEE LIVER CANCER DENA DN | 74 | 45 | All SZGR 2.0 genes in this pathway |
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
SASSON RESPONSE TO GONADOTROPHINS UP | 91 | 59 | All SZGR 2.0 genes in this pathway |
SASSON RESPONSE TO FORSKOLIN UP | 90 | 58 | All SZGR 2.0 genes in this pathway |
KIM ALL DISORDERS CALB1 CORR DN | 37 | 20 | All SZGR 2.0 genes in this pathway |