Gene Page: BIRC2

Summary
GeneID  329
Symbol  BIRC2
Synonyms  API1|HIAP2|Hiap-2|MIHB|RNF48|cIAP1
Description  baculoviral IAP repeat-containing 2
See related  HGNC:590|MIM:601712|Ensembl:ENSG00000110330|HPRD:03419|
Locus tag  -
Gene type  protein-coding
Map location  11q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AC087645.20.990.94
FAM64A0.980.87
CCNB20.980.85
KIF20A0.980.85
KIF2C0.980.76
AURKB0.970.85
GTSE10.970.82
BUB10.970.84
UBE2C0.970.87
CCNA20.970.81
Top 10 negatively co-expressed genes
HLA-F-0.39-0.76
FBXO2-0.39-0.70
C5orf53-0.39-0.69
SLC9A3R2-0.38-0.53
PTH1R-0.38-0.65
ASPHD1-0.37-0.58
ALDOC-0.37-0.70
AIFM3-0.36-0.68
TNFSF12-0.36-0.63
TINAGL1-0.36-0.71
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11084335 |16282325 |18022362 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001890placenta developmentIEA-
GO:0007166cell surface receptor linked signal transductionTAS8548810 
GO:0042981regulation of apoptosisIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP11106668 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD,BioGRID9384571 
CASP7CMH-1 | ICE-LAP3 | MCH3caspase 7, apoptosis-related cysteine peptidasec-IAP1 interacts with caspase-7.BIND15580265 
-HPRD,BioGRID9384571 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseAffinity Capture-WesternBioGRID12887920 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD,BioGRID9545235 
DIABLODIABLO-S | FLJ10537 | FLJ25049 | SMAC | SMAC3diablo homolog (Drosophila)-HPRD,BioGRID10929712 
GSPT1551G9.2 | ETF3A | FLJ38048 | FLJ39067 | GST1 | eRF3aG1 to S phase transition 1-HPRD,BioGRID12865429 
HTRA2OMI | PARK13 | PRSS25HtrA serine peptidase 2-HPRD,BioGRID11604410 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobinTwo-hybridBioGRID16189514 
LTBRCD18 | D12S370 | LT-BETA-R | TNF-R-III | TNFCR | TNFR-RP | TNFR2-RP | TNFRSF3lymphotoxin beta receptor (TNFR superfamily, member 3)cIAP1 interacts with LTBR.BIND12571250 
MAGEA11MAGE-11 | MAGE11 | MAGEA-11 | MGC10511melanoma antigen family A, 11Two-hybridBioGRID16189514 
RIPK2CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2receptor-interacting serine-threonine kinase 2-HPRD,BioGRID9642260 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1AAffinity Capture-WesternBioGRID8943045 
TNFSF14CD258 | HVEML | LIGHT | LTg | TR2tumor necrosis factor (ligand) superfamily, member 14Affinity Capture-MS
Affinity Capture-Western
BioGRID12571250 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD8943045 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1c-IAP1 interacts with TRAF1.BIND11907583 
-HPRD,BioGRID9384571 |11907583 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2c-IAP1 interacts with and ubiquitinates TRAF2.BIND11907583 
-HPRD8643514 |9384571 
|11907583 
Affinity Capture-Western
in vitro
Reconstituted Complex
Two-hybrid
BioGRID8643514 |8943045 
|9384571 |11907583 
|16189514 
UBE2J1CGI-76 | HSPC153 | HSPC205 | HSU93243 | MGC12555 | NCUBE1 | Ubc6pubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)UBE2J1 (hUbc6e), an E2 ubiquitin-conjugating enzyme, interacts with and assists autoubiquitination of BIRC2 (c-IAP1), an E3 ubiquitin-protein ligase.BIND15861135 
 


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