Gene Page

Gene Page: APLP2

Summary

GeneID

334

Symbol

APLP2

Synonyms

APPH|APPL2|CDEBP

Description

amyloid beta (A4) precursor-like protein 2

Locus tag

Gene type

protein-coding

Map location

11q23-q25|11q24

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Expression

P value: 2.34

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.6867

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003677

DNA binding

NAS

7702756

GO:0004867

serine-type endopeptidase inhibitor activity

IEA

GO:0005515

protein binding

IPI

8855266

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007186

G-protein coupled receptor protein signaling pathway

NAS

8220435

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IDA

7702756

GO:0016021

integral to membrane

NAS

8485127

GO:0005886

plasma membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APBB1	FE65 \| MGC:9072 \| RIR	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	Affinity Capture-Western Reconstituted Complex	BioGRID	8855266 \|10081969
APBB1	FE65 \| MGC:9072 \| RIR		-	HPRD	8894693
APBB2	DKFZp434E033 \| FE65L \| FE65L1 \| MGC35575	amyloid beta (A4) precursor protein-binding, family B, member 2	-	HPRD	8855266
APBB3	FE65L2 \| MGC150555 \| MGC87674 \| SRA	amyloid beta (A4) precursor protein-binding, family B, member 3	-	HPRD,BioGRID	10081969
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Far Western	BioGRID	11746496
DAB1	-	disabled homolog 1 (Drosophila)	-	HPRD,BioGRID	10460257
DAB2	DOC-2 \| DOC2 \| FLJ26626	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	Reconstituted Complex	BioGRID	11247302
SFN	YWHAS	stratifin	Affinity Capture-MS	BioGRID	15778465

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	145	151	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-139	146	153	1A,m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-144	145	151	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-153	1264	1270	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-181	1314	1320	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	166	172	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-409-5p	1170	1176	m8	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-493-5p	1316	1322	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.