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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: IGFBP5

Summary

GeneID

3488

Symbol

IGFBP5

Synonyms

IBP5

Description

insulin-like growth factor binding protein 5

Locus tag

Gene type

protein-coding

Map location

2q33-q36

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.01016

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00916

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0031994

insulin-like growth factor I binding

IPI

10766744

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001558

regulation of cell growth

IEA

GO:0007165

signal transduction

NAS

7525452

GO:0014912

negative regulation of smooth muscle cell migration

IDA

10766744

GO:0043569

negative regulation of insulin-like growth factor receptor signaling pathway

IDA

10766744

GO:0048662

negative regulation of smooth muscle cell proliferation

IDA

10766744

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005576

extracellular region

NAS

14718574

GO:0005783

endoplasmic reticulum

IEA

GO:0016942

insulin-like growth factor binding protein complex

10766744

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADAM12	MCMP \| MCMPMltna \| MLTN \| MLTNA	ADAM metallopeptidase domain 12	-	HPRD,BioGRID	11095942
BAT3	BAG-6 \| BAG6 \| D6S52E \| G3	HLA-B associated transcript 3	Two-hybrid	BioGRID	16169070
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	-	HPRD,BioGRID	11821401
IGF1	IGFI	insulin-like growth factor 1 (somatomedin C)	IGF-I interacts with IGFBP-5.	BIND	10407151
IGF1	IGFI	insulin-like growth factor 1 (somatomedin C)	-	HPRD,BioGRID	9497324
IGF2	C11orf43 \| FLJ22066 \| FLJ44734 \| INSIGF \| pp9974	insulin-like growth factor 2 (somatomedin A)	IGF-II interacts with IGFBP-5.	BIND	10407151
IGF2	C11orf43 \| FLJ22066 \| FLJ44734 \| INSIGF \| pp9974	insulin-like growth factor 2 (somatomedin A)	-	HPRD,BioGRID	9497324
IGFALS	ALS	insulin-like growth factor binding protein, acid labile subunit	-	HPRD,BioGRID	9497324 \|9786878
SERPINE1	PAI \| PAI-1 \| PAI1 \| PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	in vitro in vivo	BioGRID	9202242
SPP1	BNSP \| BSPI \| ETA-1 \| MGC110940 \| OPN	secreted phosphoprotein 1	-	HPRD,BioGRID	10698186
TF	DKFZp781D0156 \| PRO1557 \| PRO2086	transferrin	-	HPRD	11297622
THBS1	THBS \| TSP \| TSP1	thrombospondin 1	Reconstituted Complex	BioGRID	10698186
THBS1	THBS \| TSP \| TSP1	thrombospondin 1	IGFBP-5 interacts with TS-1.	BIND	15700281
VTN	V75 \| VN \| VNT	vitronectin	-	HPRD,BioGRID	11751588

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	663	669	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-101	3821	3827	m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-136	3937	3943	m8	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-137	4240	4246	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-140	3839	3845	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-143	91	98	1A,m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-149	2611	2617	m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-193	2485	2492	1A,m8	hsa-miR-193a	AACUGGCCUACAAAGUCCCAG
miR-193	2485	2492	1A,m8	hsa-miR-193b	AACUGGCCCUCAAAGUCCCGCUUU
miR-203.1	87	93	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-24	2609	2616	1A,m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.