Gene Page: HCN1

Summary
GeneID  348980
Symbol  HCN1
Synonyms  BCNG-1|BCNG1|HAC-2
Description  hyperpolarization activated cyclic nucleotide-gated potassium channel 1
See related  HGNC:4845|MIM:602780|Ensembl:ENSG00000164588|HPRD:09099|
Locus tag  -
Gene type  protein-coding
Map location  5p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005244voltage-gated ion channel activityIEA-
GO:0005249voltage-gated potassium channel activityIEA-
GO:0005272sodium channel activityIEA-
GO:0030552cAMP bindingIEA-
GO:0030955potassium ion bindingIEA-
GO:0031402sodium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006814sodium ion transportIEA-
GO:0006811ion transportIEA-
GO:0006813potassium ion transportNAS9405696 
GO:0045176apical protein localizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030425dendriteIEAneuron, axon, dendrite (GO term level: 6)-
GO:0030424axonIEAneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0016020membraneIEA-
GO:0016021integral to membraneNAS9405696 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
HCN1BCNG-1 | BCNG1 | HAC-2hyperpolarization activated cyclic nucleotide-gated potassium channel 1-HPRD,BioGRID11133998 |12034718 
HCN2BCNG-2 | BCNG2 | HAC-1hyperpolarization activated cyclic nucleotide-gated potassium channel 2-HPRD11133998 |12034718 
Affinity Capture-Western
Two-hybrid		BioGRID12034718 |12928435 
HCN3KIAA1535 | MGC131493hyperpolarization activated cyclic nucleotide-gated potassium channel 3Affinity Capture-WesternBioGRID12928435 
HCN4-hyperpolarization activated cyclic nucleotide-gated potassium channel 4Affinity Capture-WesternBioGRID12928435 
 
Pathway annotation
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10233323401A,m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-135261226191A,m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-141/200a2182251A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-224114511511Ahsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-381939945m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-410217421801Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-43120272033m8hsa-miR-431UGUCUUGCAGGCCGUCAUGCA
miR-485-3p25672573m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-4961401461Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-5437007061Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-54419251Ahsa-miR-544AUUCUGCAUUUUUAGCAAGU
miR-7229235m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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