Gene Page: KLK3
Summary ?
| GeneID | 354 |
| Symbol | KLK3 |
| Synonyms | APS|KLK2A1|PSA|hK3 |
| Description | kallikrein related peptidase 3 |
| Reference | MIM:176820|HGNC:HGNC:6364|Ensembl:ENSG00000142515|HPRD:01461|Vega:OTTHUMG00000182867 |
| Gene type | protein-coding |
| Map location | 19q13.41 |
| Pascal p-value | 0.733 |
| Fetal beta | 0.277 |
| eGene | Cerebellum Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| CV:PheWAS | Phenome-wide association studies (PheWAS) | 157 SNPs associated with schizophrenia | 1 |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
CV:PheWAS
| SNP ID | Chromosome | Position | Allele | P | Function | Gene | Up/Down Distance |
|---|---|---|---|---|---|---|---|
| rs2735839 | 19 | 51364623 | null | 1.78 | KLK3 | null |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17714461 | chr19 | 51425105 | KLK3 | 354 | 0.02 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ATP9A | 0.85 | 0.86 |
| PCDH10 | 0.83 | 0.85 |
| PYGO2 | 0.82 | 0.82 |
| ARL4C | 0.82 | 0.85 |
| SRGAP3 | 0.81 | 0.85 |
| TMEM127 | 0.81 | 0.85 |
| ARHGEF7 | 0.81 | 0.86 |
| KLHL18 | 0.81 | 0.83 |
| FNIP2 | 0.80 | 0.85 |
| DCBLD2 | 0.80 | 0.83 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.62 | -0.69 |
| AF347015.31 | -0.61 | -0.67 |
| FXYD1 | -0.60 | -0.64 |
| AF347015.21 | -0.60 | -0.70 |
| AF347015.33 | -0.59 | -0.62 |
| AF347015.8 | -0.58 | -0.66 |
| MT-CYB | -0.58 | -0.64 |
| HIGD1B | -0.57 | -0.63 |
| AC021016.1 | -0.57 | -0.62 |
| AF347015.27 | -0.57 | -0.63 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | IEA | glutamate (GO term level: 7) | - |
| GO:0004252 | serine-type endopeptidase activity | NAS | glutamate (GO term level: 7) | - |
| GO:0003824 | catalytic activity | IEA | - | |
| GO:0008233 | peptidase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006508 | proteolysis | IEA | - | |
| GO:0006508 | proteolysis | NAS | - | |
| GO:0016525 | negative regulation of angiogenesis | NAS | 10675891 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | NAS | 14718574 | |
| GO:0005634 | nucleus | IDA | 18029348 | |
| GO:0005730 | nucleolus | IDA | 18029348 | |
| GO:0005737 | cytoplasm | IDA | 18029348 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| A2M | CPAMD5 | DKFZp779B086 | FWP007 | S863-7 | alpha-2-macroglobulin | - | HPRD | 8583572 |
| A2M | CPAMD5 | DKFZp779B086 | FWP007 | S863-7 | alpha-2-macroglobulin | Affinity Capture-Western | BioGRID | 1702714 |
| AR | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | androgen receptor | AR interacts with p-PSA. | BIND | 15542435 |
| CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | CTNNB1 (beta-catenin) interacts with the KLK3 (PSA) promoter. | BIND | 15829968 |
| EPOR | MGC138358 | erythropoietin receptor | - | HPRD | 10374881 |
| FN1 | CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSF | fibronectin 1 | - | HPRD | 9016396 |
| IGFBP3 | BP-53 | IBP3 | insulin-like growth factor binding protein 3 | - | HPRD,BioGRID | 1383255 |10511594 |
| KAT5 | ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2 | K(lysine) acetyltransferase 5 | HTATIP (Tip60) interacts with the KLK3 (PSA) promoter. | BIND | 15829968 |
| POLR2A | MGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1 | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | Pol II interacts with p-PSA. | BIND | 15542435 |
| PZP | CPAMD6 | MGC133093 | pregnancy-zone protein | - | HPRD | 1702714 |
| RUVBL1 | ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49A | RuvB-like 1 (E. coli) | RUVBL1 (pontin) interacts with the KLK3 (PSA) promoter. | BIND | 15829968 |
| SERPINA1 | A1A | A1AT | AAT | MGC23330 | MGC9222 | PI | PI1 | PRO2275 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | Affinity Capture-Western | BioGRID | 1702714 |
| SERPINA3 | AACT | ACT | GIG24 | GIG25 | MGC88254 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | - | HPRD | 8732755 |9261179 |10759471 |11317942 |11735417 |
| SERPINA5 | PAI3 | PCI | PLANH3 | PROCI | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | - | HPRD,BioGRID | 7509746 |8665956 |8732755 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG PROSTATE CANCER | 89 | 75 | All SZGR 2.0 genes in this pathway |
| PID AR PATHWAY | 61 | 46 | All SZGR 2.0 genes in this pathway |
| PID AR TF PATHWAY | 53 | 38 | All SZGR 2.0 genes in this pathway |
| PID HNF3A PATHWAY | 44 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME DIABETES PATHWAYS | 133 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | 16 | 12 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO ANDROGEN UP | 29 | 21 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO FORSKOLIN UP | 23 | 17 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS DN | 352 | 225 | All SZGR 2.0 genes in this pathway |
| GOERING BLOOD HDL CHOLESTEROL QTL TRANS | 14 | 7 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| RADAEVA RESPONSE TO IFNA1 UP | 52 | 40 | All SZGR 2.0 genes in this pathway |
| NELSON RESPONSE TO ANDROGEN UP | 86 | 61 | All SZGR 2.0 genes in this pathway |
| YEGNASUBRAMANIAN PROSTATE CANCER | 128 | 60 | All SZGR 2.0 genes in this pathway |
| OSADA ASCL1 TARGETS UP | 46 | 30 | All SZGR 2.0 genes in this pathway |
| CHNG MULTIPLE MYELOMA HYPERPLOID UP | 52 | 25 | All SZGR 2.0 genes in this pathway |
| VART KSHV INFECTION ANGIOGENIC MARKERS DN | 138 | 92 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER SURVIVAL UP | 185 | 112 | All SZGR 2.0 genes in this pathway |
| LIU VAV3 PROSTATE CARCINOGENESIS UP | 89 | 61 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE UP | 442 | 263 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |