Gene Page: IL4R

Summary
GeneID  3566
Symbol  IL4R
Synonyms  CD124|IL4RA
Description  interleukin 4 receptor
See related  HGNC:6015|MIM:147781|Ensembl:ENSG00000077238|HPRD:00990|
Locus tag  -
Gene type  protein-coding
Map location  16p12.1-p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005057receptor signaling protein activityTAS2307934 
GO:0004872receptor activityIEA-
GO:0004896cytokine receptor activityIEA-
GO:0005515protein bindingIPI8266078 
GO:0004913interleukin-4 receptor activityTAS2307934 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS2307934 
GO:0006955immune responseTAS2307934 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS2307934 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARIH2ARI2 | FLJ10938 | FLJ33921 | TRIAD1ariadne homolog 2 (Drosophila)Two-hybridBioGRID16169070 
FESFPSfeline sarcoma oncogene-HPRD,BioGRID7518439 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID12960323 
IL-4R-alpha interacts with RACK-1. This interaction was modelled on a demonstrated interaction between IL-4R-alpha from an unspecified species and human RACK-1.BIND12960323 
IL13ALRH | BHR1 | IL-13 | MGC116786 | MGC116788 | MGC116789 | P600interleukin 13-HPRD,BioGRID11709756 
IL13RA1CD213A1 | IL-13Ra | NR4interleukin 13 receptor, alpha 1-HPRD,BioGRID8910586 
IL2RGCD132 | IMD4 | SCIDX | SCIDX1interleukin 2 receptor, gamma (severe combined immunodeficiency)-HPRD,BioGRID8266076 
IL4BCGF-1 | BCGF1 | BSF1 | IL-4 | MGC79402interleukin 4-HPRD,BioGRID11786020 
IL4R Interacts with IL4.BIND8266078 
IL4R -alpha(PDB ID: 1IAR_B) interacts with IL4(PDB ID: 1IAR_A).BIND10219247 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDa-HPRD,BioGRID11714803 
IRS1HIRS-1insulin receptor substrate 1-HPRD,BioGRID8599766 
IRS2-insulin receptor substrate 2-HPRD,BioGRID8954948 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD,BioGRID12133952 
JAK1 interacts with IL4R-alpha.BIND12133952 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD,BioGRID7538655 
NCF1FLJ79451 | NCF1A | NOXO2 | SH3PXD1A | p47phoxneutrophil cytosolic factor 1in vivoBioGRID10369419 
NCF1CSH3PXD1Cneutrophil cytosolic factor 1C pseudogene-HPRD10369419 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID11714803 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID11714803 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID10652211 |11714803 
STAT6D12S1644 | IL-4-STAT | STAT6B | STAT6Csignal transducer and activator of transcription 6, interleukin-4 inducedIL-4 receptor-alpha interacts with STAT 6.BIND8816495 
 


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