Gene Page: IL16

Summary
GeneID  3603
Symbol  IL16
Synonyms  FLJ16806|FLJ42735|FLJ44234|HsT19289|IL-16|LCF|prIL-16
Description  interleukin 16 (lymphocyte chemoattractant factor)
See related  HGNC:5980|MIM:603035|Ensembl:ENSG00000172349|HPRD:04329|
Locus tag  -
Gene type  protein-coding
Map location  15q26.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0548 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TTC350.660.66
AFMID0.650.65
PPAP2A0.650.68
LAYN0.650.65
UNC500.630.65
HEBP10.630.65
BIN10.630.65
PLA2G4C0.610.65
CCDC28A0.600.64
PION0.600.64
Top 10 negatively co-expressed genes
SOX11-0.44-0.27
IGFBPL1-0.44-0.20
EPHB1-0.42-0.19
KIF26A-0.42-0.31
SEMA3F-0.42-0.28
VANGL2-0.41-0.16
SERINC2-0.41-0.27
GPC2-0.41-0.22
LRRC3-0.41-0.22
ACVR2B-0.40-0.16
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005125cytokine activityIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006955immune responseTAS9144227 
GO:0006935chemotaxisIEA-
GO:0030595leukocyte chemotaxisIEA-
GO:0050930induction of positive chemotaxisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceTAS9144227 
GO:0005622intracellularIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD4CD4mutCD4 molecule-HPRD,BioGRID1851800|7910967 
DMRTB1-DMRT-like family B with proline-rich C-terminal, 1Two-hybridBioGRID16189514 
EFEMP2FBLN4 | MBP1 | UPH1EGF-containing fibulin-like extracellular matrix protein 2Two-hybridBioGRID16189514 
GRIN2ANMDAR2A | NR2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2Anpro-IL-16 interacts with NR2A.BIND12923170 
-HPRD,BioGRID10479680 
GRIN2BMGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3glutamate receptor, ionotropic, N-methyl D-aspartate 2B-HPRD,BioGRID10479680 
GRIN2CNMDAR2C | NR2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C-HPRD,BioGRID10479680 
GRIN2DEB11 | NMDAR2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D-HPRD,BioGRID10479680 
IL16FLJ16806 | FLJ42735 | FLJ44234 | HsT19289 | IL-16 | LCF | prIL-16interleukin 16 (lymphocyte chemoattractant factor)-HPRD,BioGRID7910967 
KCND1KV4.1potassium voltage-gated channel, Shal-related subfamily, member 1-HPRD,BioGRID10479680 
KCND2KIAA1044 | KV4.2 | MGC119702 | MGC119703 | RK5potassium voltage-gated channel, Shal-related subfamily, member 2-HPRD,BioGRID10479680 
KCNJ10BIRK-10 | KCNJ13-PEN | KIR1.2 | KIR4.1potassium inwardly-rectifying channel, subfamily J, member 10-HPRD,BioGRID10479680 
KCNJ15IRKK | KIR1.3 | KIR4.2 | MGC13584potassium inwardly-rectifying channel, subfamily J, member 15-HPRD,BioGRID10479680 
KCNJ2HHBIRK1 | HHIRK1 | IRK1 | KIR2.1 | LQT7 | SQT3potassium inwardly-rectifying channel, subfamily J, member 2-HPRD,BioGRID10479680 
KCNJ4HIR | HIRK2 | HRK1 | IRK3 | Kir2.3 | MGC142066 | MGC142068potassium inwardly-rectifying channel, subfamily J, member 4-HPRD,BioGRID10479680 
PPP1R12AMBS | MGC133042 | MYPT1protein phosphatase 1, regulatory (inhibitor) subunit 12AThe PDZ2 domain of pro-IL-16 interacts with the carboxy terminal of MYPT1.BIND12923170 
-HPRD,BioGRID12923170 
PPP1R12BMGC131980 | MGC87886 | MYPT2protein phosphatase 1, regulatory (inhibitor) subunit 12B-HPRD,BioGRID12923170 
npro-IL-16 interacts with MYPT2.BIND12923170 
The PDZ2 domain of pro-IL-16 interacts with the carboxy terminal of MYPT2.BIND12923170 
PPP1R12CDKFZp434D0412 | LENG3 | p84protein phosphatase 1, regulatory (inhibitor) subunit 12CThe PDZ2 domain of pro-IL-16 interacts with the carboxy terminal of MSB85.BIND12923170 
-HPRD,BioGRID12923170 
SSSCA1p27Sjogren syndrome/scleroderma autoantigen 1Two-hybridBioGRID16189514 
USHBP1AIEBP | FLJ38709 | FLJ90681 | MCC2Usher syndrome 1C binding protein 1Two-hybridBioGRID16189514 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-125/3516773m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-5046975m8hsa-miR-504AGACCCUGGUCUGCACUCUAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.