Summary ?
GeneID3728
SymbolJUP
SynonymsARVD12|CTNNG|DP3|DPIII|PDGB|PKGB
Descriptionjunction plakoglobin
ReferenceMIM:173325|HGNC:HGNC:6207|Ensembl:ENSG00000173801|HPRD:01414|Vega:OTTHUMG00000133494
Gene typeprotein-coding
Map location17q21
Pascal p-value0.677
Fetal beta1.42
DMG1 (# studies)
eGeneCerebellar Hemisphere
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0021 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg175475371739845544JUP1.38E-8-0.0085.41E-6DMG:Jaffe_2016
cg036859101739844834JUP2.42E-8-0.0097.86E-6DMG:Jaffe_2016
cg053256991739890756JUP8.11E-8-0.0171.89E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CHST100.730.64
CTTNBP20.730.67
DAP0.720.67
SLA0.720.68
DOPEY20.720.67
C8orf790.710.66
POU3F20.710.60
RAI140.700.62
SEMA3C0.700.67
GPR120.700.67
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TNFSF12-0.48-0.54
SLC16A11-0.47-0.55
C5orf53-0.47-0.57
HLA-F-0.47-0.56
SPARCL1-0.46-0.57
PTH1R-0.46-0.55
CMTM8-0.46-0.52
CXCL14-0.46-0.65
AF347015.31-0.45-0.58
AF347015.27-0.45-0.58

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005198structural molecule activityIEA-
GO:0008092cytoskeletal protein bindingTAS1639850 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionNAS1639850 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIEA-
GO:0005856cytoskeletonTAS1639850 
GO:0005624membrane fractionTAS1639850 
GO:0005625soluble fractionTAS1639850 
GO:0005737cytoplasmTAS1639850 
GO:0016020membraneIEA-
GO:0030018Z discIEA-
GO:0005913cell-cell adherens junctionIEA-
GO:0030057desmosomeIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliAffinity Capture-Western
Reconstituted Complex
BioGRID7651399 |8074697 
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaTwo-hybridBioGRID16169070 
BIRC2API1 | HIAP2 | Hiap-2 | MIHB | RNF48 | cIAP1baculoviral IAP repeat-containing 2Two-hybridBioGRID16189514 
BTRCBETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCPbeta-transducin repeat containing-HPRD,BioGRID10803460 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)-HPRD1639850 |8207061 
|10959047 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)Affinity Capture-Western
Reconstituted Complex
BioGRID1639850 |7542250 
|8074697 |8207061 
|9535896 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)-HPRD1639850 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)Affinity Capture-MS
Affinity Capture-Western
BioGRID7650039 |14625392 
CDH3CDHP | HJMD | PCADcadherin 3, type 1, P-cadherin (placental)Affinity Capture-Western
Co-purification
BioGRID10910767 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)-HPRD9739078 |12003790 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)Affinity Capture-WesternBioGRID9434630 |12003790 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDa-HPRD,BioGRID7650039 |9110993 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID9535896 |11712088 
CTNNBIP1ICAT | MGC15093catenin, beta interacting protein 1Affinity Capture-MS
Two-hybrid
BioGRID16189514 |17353931 
DSC1CDHF1 | DG2/DG3desmocollin 1-HPRD7971964 |9606214 
DSC2ARVD11 | CDHF2 | DG2 | DGII/III | DKFZp686I11137 | DSC3desmocollin 2-HPRD,BioGRID9443898 
DSC3CDHF3 | DSC | DSC1 | DSC2 | DSC4 | HT-CPdesmocollin 3-HPRD,BioGRID10769211 
DSG1CDHF4 | DG1 | DSGdesmoglein 1-HPRD,BioGRID7738346 |9606214 
DSG2ARVC10 | ARVD10 | CDHF5 | HDGC | MGC117034 | MGC117036 | MGC117037desmoglein 2-HPRD,BioGRID8749329 |10769205 
|11710948 
DSG3CDHF6 | DKFZp686P23184 | PVAdesmoglein 3 (pemphigus vulgaris antigen)Affinity Capture-WesternBioGRID7738346 
DSPDPI | DPIIdesmoplakin-HPRD,BioGRID9348293 
DSPDPI | DPIIdesmoplakinPlakoglobin interacts with desmoplakin.BIND12426320 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Reconstituted ComplexBioGRID9535896 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID7702605 
GJB1CMTX | CMTX1 | CX32gap junction protein, beta 1, 32kDaAffinity Capture-WesternBioGRID7971964 
LGALS9HUAT | LGALS9A | MGC117375 | MGC125973 | MGC125974lectin, galactoside-binding, soluble, 9Affinity Capture-MSBioGRID17353931 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associated-HPRD9139698 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associatedAffinity Capture-Western
Co-localization
BioGRID12939402 
NFKBIEIKBEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilonTwo-hybridBioGRID16189514 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion moleculeAffinity Capture-WesternBioGRID10801826 
PHB2BAP | BCAP37 | Bap37 | MGC117268 | PNAS-141 | REA | p22prohibitin 2Affinity Capture-MSBioGRID17353931 
PKD1PBPpolycystic kidney disease 1 (autosomal dominant)-HPRD11274246 
PKP2ARVD9plakophilin 2-HPRD,BioGRID11790773 
PKP3-plakophilin 3PKP3 interacts with JUP(Pg)BIND12707304 
PKP3-plakophilin 3Two-hybridBioGRID12707304 
PTPN14MGC126803 | PEZ | PTP36protein tyrosine phosphatase, non-receptor type 14-HPRD,BioGRID12808048 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, F-HPRD,BioGRID9245795 
PTPRJCD148 | DEP1 | HPTPeta | R-PTP-ETA | SCC1protein tyrosine phosphatase, receptor type, J-HPRD12370829 
PTPRKDKFZp686C2268 | DKFZp779N1045 | R-PTP-kappaprotein tyrosine phosphatase, receptor type, K-HPRD,BioGRID8663237 
RAB8BFLJ38125RAB8B, member RAS oncogene familyAffinity Capture-WesternBioGRID12639940 
RIBC2C22orf11RIB43A domain with coiled-coils 2Two-hybridBioGRID16189514 
TCF7L2TCF-4 | TCF4transcription factor 7-like 2 (T-cell specific, HMG-box)-HPRD,BioGRID11711551 
WDYHV1C8orf32 | FLJ10204WDYHV motif containing 1Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA 6047All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC 7659All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 4838All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY 3933All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY 2119All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY 3332All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME ADHERENS JUNCTIONS INTERACTIONS 2720All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION 5631All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION 7843All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430232All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258141All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN GRANULOCYTE UP 159All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185126All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP 5534All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS DN 13377All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 14295All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN 2513All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178108All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY 6648All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848527All SZGR 2.0 genes in this pathway
LIU NASOPHARYNGEAL CARCINOMA 7038All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382224All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261155All SZGR 2.0 genes in this pathway
WU CELL MIGRATION 184114All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290172All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179105All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA 6947All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 6647All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
CROMER METASTASIS DN 8158All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA UP 5233All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 7962All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C2 2518All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 5843All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS DN 2521All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 9671All SZGR 2.0 genes in this pathway
SAFFORD T LYMPHOCYTE ANERGY 8754All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 9 9259All SZGR 2.0 genes in this pathway
KANG CISPLATIN RESISTANCE UP 1911All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
MISHRA CARCINOMA ASSOCIATED FIBROBLAST DN 2413All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
MUELLER COMMON TARGETS OF AML FUSIONS UP 1410All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395249All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN 8053All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 7547All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE B ALL DN 1510All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297194All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 9554All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-125/3517547601Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-381109511011Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-911031109m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA