Gene Page: JUP
Summary ?
GeneID | 3728 |
Symbol | JUP |
Synonyms | ARVD12|CTNNG|DP3|DPIII|PDGB|PKGB |
Description | junction plakoglobin |
Reference | MIM:173325|HGNC:HGNC:6207|Ensembl:ENSG00000173801|HPRD:01414|Vega:OTTHUMG00000133494 |
Gene type | protein-coding |
Map location | 17q21 |
Pascal p-value | 0.677 |
Fetal beta | 1.42 |
DMG | 1 (# studies) |
eGene | Cerebellar Hemisphere |
Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 3 |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0021 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg17547537 | 17 | 39845544 | JUP | 1.38E-8 | -0.008 | 5.41E-6 | DMG:Jaffe_2016 |
cg03685910 | 17 | 39844834 | JUP | 2.42E-8 | -0.009 | 7.86E-6 | DMG:Jaffe_2016 |
cg05325699 | 17 | 39890756 | JUP | 8.11E-8 | -0.017 | 1.89E-5 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
CHST10 | 0.73 | 0.64 |
CTTNBP2 | 0.73 | 0.67 |
DAP | 0.72 | 0.67 |
SLA | 0.72 | 0.68 |
DOPEY2 | 0.72 | 0.67 |
C8orf79 | 0.71 | 0.66 |
POU3F2 | 0.71 | 0.60 |
RAI14 | 0.70 | 0.62 |
SEMA3C | 0.70 | 0.67 |
GPR12 | 0.70 | 0.67 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
TNFSF12 | -0.48 | -0.54 |
SLC16A11 | -0.47 | -0.55 |
C5orf53 | -0.47 | -0.57 |
HLA-F | -0.47 | -0.56 |
SPARCL1 | -0.46 | -0.57 |
PTH1R | -0.46 | -0.55 |
CMTM8 | -0.46 | -0.52 |
CXCL14 | -0.46 | -0.65 |
AF347015.31 | -0.45 | -0.58 |
AF347015.27 | -0.45 | -0.58 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005198 | structural molecule activity | IEA | - | |
GO:0008092 | cytoskeletal protein binding | TAS | 1639850 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007155 | cell adhesion | NAS | 1639850 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005829 | cytosol | IEA | - | |
GO:0005856 | cytoskeleton | TAS | 1639850 | |
GO:0005624 | membrane fraction | TAS | 1639850 | |
GO:0005625 | soluble fraction | TAS | 1639850 | |
GO:0005737 | cytoplasm | TAS | 1639850 | |
GO:0016020 | membrane | IEA | - | |
GO:0030018 | Z disc | IEA | - | |
GO:0005913 | cell-cell adherens junction | IEA | - | |
GO:0030057 | desmosome | IEA | - |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
APC | BTPS2 | DP2 | DP2.5 | DP3 | GS | adenomatous polyposis coli | Affinity Capture-Western Reconstituted Complex | BioGRID | 7651399 |8074697 |
ARHGDIA | GDIA1 | MGC117248 | RHOGDI | RHOGDI-1 | Rho GDP dissociation inhibitor (GDI) alpha | Two-hybrid | BioGRID | 16169070 |
BIRC2 | API1 | HIAP2 | Hiap-2 | MIHB | RNF48 | cIAP1 | baculoviral IAP repeat-containing 2 | Two-hybrid | BioGRID | 16189514 |
BTRC | BETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCP | beta-transducin repeat containing | - | HPRD,BioGRID | 10803460 |
CDH1 | Arc-1 | CD324 | CDHE | ECAD | LCAM | UVO | cadherin 1, type 1, E-cadherin (epithelial) | - | HPRD | 1639850 |8207061 |10959047 |
CDH1 | Arc-1 | CD324 | CDHE | ECAD | LCAM | UVO | cadherin 1, type 1, E-cadherin (epithelial) | Affinity Capture-Western Reconstituted Complex | BioGRID | 1639850 |7542250 |8074697 |8207061 |9535896 |
CDH2 | CD325 | CDHN | CDw325 | NCAD | cadherin 2, type 1, N-cadherin (neuronal) | - | HPRD | 1639850 |
CDH2 | CD325 | CDHN | CDw325 | NCAD | cadherin 2, type 1, N-cadherin (neuronal) | Affinity Capture-MS Affinity Capture-Western | BioGRID | 7650039 |14625392 |
CDH3 | CDHP | HJMD | PCAD | cadherin 3, type 1, P-cadherin (placental) | Affinity Capture-Western Co-purification | BioGRID | 10910767 |
CDH5 | 7B4 | CD144 | FLJ17376 | cadherin 5, type 2 (vascular endothelium) | - | HPRD | 9739078 |12003790 |
CDH5 | 7B4 | CD144 | FLJ17376 | cadherin 5, type 2 (vascular endothelium) | Affinity Capture-Western | BioGRID | 9434630 |12003790 |
CTNNA1 | CAP102 | FLJ36832 | catenin (cadherin-associated protein), alpha 1, 102kDa | - | HPRD,BioGRID | 7650039 |9110993 |
CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | Affinity Capture-Western | BioGRID | 9535896 |11712088 |
CTNNBIP1 | ICAT | MGC15093 | catenin, beta interacting protein 1 | Affinity Capture-MS Two-hybrid | BioGRID | 16189514 |17353931 |
DSC1 | CDHF1 | DG2/DG3 | desmocollin 1 | - | HPRD | 7971964 |9606214 |
DSC2 | ARVD11 | CDHF2 | DG2 | DGII/III | DKFZp686I11137 | DSC3 | desmocollin 2 | - | HPRD,BioGRID | 9443898 |
DSC3 | CDHF3 | DSC | DSC1 | DSC2 | DSC4 | HT-CP | desmocollin 3 | - | HPRD,BioGRID | 10769211 |
DSG1 | CDHF4 | DG1 | DSG | desmoglein 1 | - | HPRD,BioGRID | 7738346 |9606214 |
DSG2 | ARVC10 | ARVD10 | CDHF5 | HDGC | MGC117034 | MGC117036 | MGC117037 | desmoglein 2 | - | HPRD,BioGRID | 8749329 |10769205 |11710948 |
DSG3 | CDHF6 | DKFZp686P23184 | PVA | desmoglein 3 (pemphigus vulgaris antigen) | Affinity Capture-Western | BioGRID | 7738346 |
DSP | DPI | DPII | desmoplakin | - | HPRD,BioGRID | 9348293 |
DSP | DPI | DPII | desmoplakin | Plakoglobin interacts with desmoplakin. | BIND | 12426320 |
EGFR | ERBB | ERBB1 | HER1 | PIG61 | mENA | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | Reconstituted Complex | BioGRID | 9535896 |
ERBB2 | CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | - | HPRD,BioGRID | 7702605 |
GJB1 | CMTX | CMTX1 | CX32 | gap junction protein, beta 1, 32kDa | Affinity Capture-Western | BioGRID | 7971964 |
LGALS9 | HUAT | LGALS9A | MGC117375 | MGC125973 | MGC125974 | lectin, galactoside-binding, soluble, 9 | Affinity Capture-MS | BioGRID | 17353931 |
MUC1 | CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUM | mucin 1, cell surface associated | - | HPRD | 9139698 |
MUC1 | CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUM | mucin 1, cell surface associated | Affinity Capture-Western Co-localization | BioGRID | 12939402 |
NFKBIE | IKBE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | Two-hybrid | BioGRID | 16189514 |
PECAM1 | CD31 | PECAM-1 | platelet/endothelial cell adhesion molecule | Affinity Capture-Western | BioGRID | 10801826 |
PHB2 | BAP | BCAP37 | Bap37 | MGC117268 | PNAS-141 | REA | p22 | prohibitin 2 | Affinity Capture-MS | BioGRID | 17353931 |
PKD1 | PBP | polycystic kidney disease 1 (autosomal dominant) | - | HPRD | 11274246 |
PKP2 | ARVD9 | plakophilin 2 | - | HPRD,BioGRID | 11790773 |
PKP3 | - | plakophilin 3 | PKP3 interacts with JUP(Pg) | BIND | 12707304 |
PKP3 | - | plakophilin 3 | Two-hybrid | BioGRID | 12707304 |
PTPN14 | MGC126803 | PEZ | PTP36 | protein tyrosine phosphatase, non-receptor type 14 | - | HPRD,BioGRID | 12808048 |
PTPRF | FLJ43335 | FLJ45062 | FLJ45567 | LAR | protein tyrosine phosphatase, receptor type, F | - | HPRD,BioGRID | 9245795 |
PTPRJ | CD148 | DEP1 | HPTPeta | R-PTP-ETA | SCC1 | protein tyrosine phosphatase, receptor type, J | - | HPRD | 12370829 |
PTPRK | DKFZp686C2268 | DKFZp779N1045 | R-PTP-kappa | protein tyrosine phosphatase, receptor type, K | - | HPRD,BioGRID | 8663237 |
RAB8B | FLJ38125 | RAB8B, member RAS oncogene family | Affinity Capture-Western | BioGRID | 12639940 |
RIBC2 | C22orf11 | RIB43A domain with coiled-coils 2 | Two-hybrid | BioGRID | 16189514 |
TCF7L2 | TCF-4 | TCF4 | transcription factor 7-like 2 (T-cell specific, HMG-box) | - | HPRD,BioGRID | 11711551 |
WDYHV1 | C8orf32 | FLJ10204 | WDYHV motif containing 1 | Two-hybrid | BioGRID | 16189514 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
KEGG ACUTE MYELOID LEUKEMIA | 60 | 47 | All SZGR 2.0 genes in this pathway |
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC | 76 | 59 | All SZGR 2.0 genes in this pathway |
PID AJDISS 2PATHWAY | 48 | 38 | All SZGR 2.0 genes in this pathway |
PID ECADHERIN NASCENT AJ PATHWAY | 39 | 33 | All SZGR 2.0 genes in this pathway |
PID ECADHERIN KERATINOCYTE PATHWAY | 21 | 19 | All SZGR 2.0 genes in this pathway |
PID NCADHERIN PATHWAY | 33 | 32 | All SZGR 2.0 genes in this pathway |
REACTOME CELL CELL COMMUNICATION | 120 | 77 | All SZGR 2.0 genes in this pathway |
REACTOME ADHERENS JUNCTIONS INTERACTIONS | 27 | 20 | All SZGR 2.0 genes in this pathway |
REACTOME CELL CELL JUNCTION ORGANIZATION | 56 | 31 | All SZGR 2.0 genes in this pathway |
REACTOME CELL JUNCTION ORGANIZATION | 78 | 43 | All SZGR 2.0 genes in this pathway |
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP | 450 | 256 | All SZGR 2.0 genes in this pathway |
VECCHI GASTRIC CANCER EARLY UP | 430 | 232 | All SZGR 2.0 genes in this pathway |
JAEGER METASTASIS DN | 258 | 141 | All SZGR 2.0 genes in this pathway |
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN GRANULOCYTE UP | 15 | 9 | All SZGR 2.0 genes in this pathway |
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP | 185 | 126 | All SZGR 2.0 genes in this pathway |
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP | 55 | 34 | All SZGR 2.0 genes in this pathway |
SENESE HDAC2 TARGETS DN | 133 | 77 | All SZGR 2.0 genes in this pathway |
JAATINEN HEMATOPOIETIC STEM CELL UP | 316 | 190 | All SZGR 2.0 genes in this pathway |
ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN | 142 | 95 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
WANG BARRETTS ESOPHAGUS DN | 25 | 13 | All SZGR 2.0 genes in this pathway |
LI AMPLIFIED IN LUNG CANCER | 178 | 108 | All SZGR 2.0 genes in this pathway |
DIRMEIER LMP1 RESPONSE EARLY | 66 | 48 | All SZGR 2.0 genes in this pathway |
NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
LIU NASOPHARYNGEAL CARCINOMA | 70 | 38 | All SZGR 2.0 genes in this pathway |
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN | 382 | 224 | All SZGR 2.0 genes in this pathway |
RICKMAN METASTASIS DN | 261 | 155 | All SZGR 2.0 genes in this pathway |
WU CELL MIGRATION | 184 | 114 | All SZGR 2.0 genes in this pathway |
BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
BENPORATH OCT4 TARGETS | 290 | 172 | All SZGR 2.0 genes in this pathway |
BENPORATH SOX2 TARGETS | 734 | 436 | All SZGR 2.0 genes in this pathway |
BENPORATH NOS TARGETS | 179 | 105 | All SZGR 2.0 genes in this pathway |
AMIT EGF RESPONSE 120 HELA | 69 | 47 | All SZGR 2.0 genes in this pathway |
ONDER CDH1 TARGETS 2 DN | 464 | 276 | All SZGR 2.0 genes in this pathway |
TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN | 66 | 47 | All SZGR 2.0 genes in this pathway |
LEI MYB TARGETS | 318 | 215 | All SZGR 2.0 genes in this pathway |
CROMER METASTASIS DN | 81 | 58 | All SZGR 2.0 genes in this pathway |
VERHAAK AML WITH NPM1 MUTATED DN | 246 | 180 | All SZGR 2.0 genes in this pathway |
CHIBA RESPONSE TO TSA UP | 52 | 33 | All SZGR 2.0 genes in this pathway |
MCCLUNG COCAINE REWARD 5D | 79 | 62 | All SZGR 2.0 genes in this pathway |
VERRECCHIA RESPONSE TO TGFB1 C2 | 25 | 18 | All SZGR 2.0 genes in this pathway |
VERRECCHIA EARLY RESPONSE TO TGFB1 | 58 | 43 | All SZGR 2.0 genes in this pathway |
JACKSON DNMT1 TARGETS DN | 25 | 21 | All SZGR 2.0 genes in this pathway |
ZAMORA NOS2 TARGETS DN | 96 | 71 | All SZGR 2.0 genes in this pathway |
SAFFORD T LYMPHOCYTE ANERGY | 87 | 54 | All SZGR 2.0 genes in this pathway |
BURTON ADIPOGENESIS 9 | 92 | 59 | All SZGR 2.0 genes in this pathway |
KANG CISPLATIN RESISTANCE UP | 19 | 11 | All SZGR 2.0 genes in this pathway |
HELLER HDAC TARGETS UP | 317 | 208 | All SZGR 2.0 genes in this pathway |
HELLER HDAC TARGETS SILENCED BY METHYLATION UP | 461 | 298 | All SZGR 2.0 genes in this pathway |
MISHRA CARCINOMA ASSOCIATED FIBROBLAST DN | 24 | 13 | All SZGR 2.0 genes in this pathway |
YOSHIMURA MAPK8 TARGETS DN | 366 | 257 | All SZGR 2.0 genes in this pathway |
MUELLER COMMON TARGETS OF AML FUSIONS UP | 14 | 10 | All SZGR 2.0 genes in this pathway |
HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | All SZGR 2.0 genes in this pathway |
FONTAINE PAPILLARY THYROID CARCINOMA DN | 80 | 53 | All SZGR 2.0 genes in this pathway |
BAE BRCA1 TARGETS UP | 75 | 47 | All SZGR 2.0 genes in this pathway |
JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
HOLLEMAN ASPARAGINASE RESISTANCE B ALL DN | 15 | 10 | All SZGR 2.0 genes in this pathway |
DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |
HECKER IFNB1 TARGETS | 95 | 54 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-125/351 | 754 | 760 | 1A | hsa-miR-125bbrain | UCCCUGAGACCCUAACUUGUGA |
hsa-miR-125abrain | UCCCUGAGACCCUUUAACCUGUG | ||||
miR-381 | 1095 | 1101 | 1A | hsa-miR-381 | UAUACAAGGGCAAGCUCUCUGU |
miR-9 | 1103 | 1109 | m8 | hsa-miR-9SZ | UCUUUGGUUAUCUAGCUGUAUGA |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.