SZGR2

Summary ?

GeneID	3728
Symbol	JUP
Synonyms	ARVD12\|CTNNG\|DP3\|DPIII\|PDGB\|PKGB
Description	junction plakoglobin
Reference	MIM:173325\|HGNC:HGNC:6207\|Ensembl:ENSG00000173801\|HPRD:01414\|Vega:OTTHUMG00000133494
Gene type	protein-coding
Map location	17q21
Pascal p-value	0.677
Fetal beta	1.42
DMG	1 (# studies)
eGene	Cerebellar Hemisphere
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	3
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0021

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg17547537	17	39845544	JUP	1.38E-8	-0.008	5.41E-6	DMG:Jaffe_2016
cg03685910	17	39844834	JUP	2.42E-8	-0.009	7.86E-6	DMG:Jaffe_2016
cg05325699	17	39890756	JUP	8.11E-8	-0.017	1.89E-5	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CHST10	0.73	0.64
CTTNBP2	0.73	0.67
DAP	0.72	0.67
SLA	0.72	0.68
DOPEY2	0.72	0.67
C8orf79	0.71	0.66
POU3F2	0.71	0.60
RAI14	0.70	0.62
SEMA3C	0.70	0.67
GPR12	0.70	0.67

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TNFSF12	-0.48	-0.54
SLC16A11	-0.47	-0.55
C5orf53	-0.47	-0.57
HLA-F	-0.47	-0.56
SPARCL1	-0.46	-0.57
PTH1R	-0.46	-0.55
CMTM8	-0.46	-0.52
CXCL14	-0.46	-0.65
AF347015.31	-0.45	-0.58
AF347015.27	-0.45	-0.58

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005198	structural molecule activity	IEA		-
GO:0008092	cytoskeletal protein binding	TAS		1639850
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007155	cell adhesion	NAS		1639850
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	IEA		-
GO:0005856	cytoskeleton	TAS		1639850
GO:0005624	membrane fraction	TAS		1639850
GO:0005625	soluble fraction	TAS		1639850
GO:0005737	cytoplasm	TAS		1639850
GO:0016020	membrane	IEA		-
GO:0030018	Z disc	IEA		-
GO:0005913	cell-cell adherens junction	IEA		-
GO:0030057	desmosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	Affinity Capture-Western Reconstituted Complex	BioGRID	7651399 \|8074697
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	Two-hybrid	BioGRID	16169070
BIRC2	API1 \| HIAP2 \| Hiap-2 \| MIHB \| RNF48 \| cIAP1	baculoviral IAP repeat-containing 2	Two-hybrid	BioGRID	16189514
BTRC	BETA-TRCP \| FBW1A \| FBXW1 \| FBXW1A \| FWD1 \| MGC4643 \| bTrCP \| bTrCP1 \| betaTrCP	beta-transducin repeat containing	-	HPRD,BioGRID	10803460
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	-	HPRD	1639850 \|8207061 \|10959047
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western Reconstituted Complex	BioGRID	1639850 \|7542250 \|8074697 \|8207061 \|9535896
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	cadherin 2, type 1, N-cadherin (neuronal)	-	HPRD	1639850
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	cadherin 2, type 1, N-cadherin (neuronal)	Affinity Capture-MS Affinity Capture-Western	BioGRID	7650039 \|14625392
CDH3	CDHP \| HJMD \| PCAD	cadherin 3, type 1, P-cadherin (placental)	Affinity Capture-Western Co-purification	BioGRID	10910767
CDH5	7B4 \| CD144 \| FLJ17376	cadherin 5, type 2 (vascular endothelium)	-	HPRD	9739078 \|12003790
CDH5	7B4 \| CD144 \| FLJ17376	cadherin 5, type 2 (vascular endothelium)	Affinity Capture-Western	BioGRID	9434630 \|12003790
CTNNA1	CAP102 \| FLJ36832	catenin (cadherin-associated protein), alpha 1, 102kDa	-	HPRD,BioGRID	7650039 \|9110993
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	Affinity Capture-Western	BioGRID	9535896 \|11712088
CTNNBIP1	ICAT \| MGC15093	catenin, beta interacting protein 1	Affinity Capture-MS Two-hybrid	BioGRID	16189514 \|17353931
DSC1	CDHF1 \| DG2/DG3	desmocollin 1	-	HPRD	7971964 \|9606214
DSC2	ARVD11 \| CDHF2 \| DG2 \| DGII/III \| DKFZp686I11137 \| DSC3	desmocollin 2	-	HPRD,BioGRID	9443898
DSC3	CDHF3 \| DSC \| DSC1 \| DSC2 \| DSC4 \| HT-CP	desmocollin 3	-	HPRD,BioGRID	10769211
DSG1	CDHF4 \| DG1 \| DSG	desmoglein 1	-	HPRD,BioGRID	7738346 \|9606214
DSG2	ARVC10 \| ARVD10 \| CDHF5 \| HDGC \| MGC117034 \| MGC117036 \| MGC117037	desmoglein 2	-	HPRD,BioGRID	8749329 \|10769205 \|11710948
DSG3	CDHF6 \| DKFZp686P23184 \| PVA	desmoglein 3 (pemphigus vulgaris antigen)	Affinity Capture-Western	BioGRID	7738346
DSP	DPI \| DPII	desmoplakin	-	HPRD,BioGRID	9348293
DSP	DPI \| DPII	desmoplakin	Plakoglobin interacts with desmoplakin.	BIND	12426320
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Reconstituted Complex	BioGRID	9535896
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD,BioGRID	7702605
GJB1	CMTX \| CMTX1 \| CX32	gap junction protein, beta 1, 32kDa	Affinity Capture-Western	BioGRID	7971964
LGALS9	HUAT \| LGALS9A \| MGC117375 \| MGC125973 \| MGC125974	lectin, galactoside-binding, soluble, 9	Affinity Capture-MS	BioGRID	17353931
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	-	HPRD	9139698
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	Affinity Capture-Western Co-localization	BioGRID	12939402
NFKBIE	IKBE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	Two-hybrid	BioGRID	16189514
PECAM1	CD31 \| PECAM-1	platelet/endothelial cell adhesion molecule	Affinity Capture-Western	BioGRID	10801826
PHB2	BAP \| BCAP37 \| Bap37 \| MGC117268 \| PNAS-141 \| REA \| p22	prohibitin 2	Affinity Capture-MS	BioGRID	17353931
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	-	HPRD	11274246
PKP2	ARVD9	plakophilin 2	-	HPRD,BioGRID	11790773
PKP3	-	plakophilin 3	PKP3 interacts with JUP(Pg)	BIND	12707304
PKP3	-	plakophilin 3	Two-hybrid	BioGRID	12707304
PTPN14	MGC126803 \| PEZ \| PTP36	protein tyrosine phosphatase, non-receptor type 14	-	HPRD,BioGRID	12808048
PTPRF	FLJ43335 \| FLJ45062 \| FLJ45567 \| LAR	protein tyrosine phosphatase, receptor type, F	-	HPRD,BioGRID	9245795
PTPRJ	CD148 \| DEP1 \| HPTPeta \| R-PTP-ETA \| SCC1	protein tyrosine phosphatase, receptor type, J	-	HPRD	12370829
PTPRK	DKFZp686C2268 \| DKFZp779N1045 \| R-PTP-kappa	protein tyrosine phosphatase, receptor type, K	-	HPRD,BioGRID	8663237
RAB8B	FLJ38125	RAB8B, member RAS oncogene family	Affinity Capture-Western	BioGRID	12639940
RIBC2	C22orf11	RIB43A domain with coiled-coils 2	Two-hybrid	BioGRID	16189514
TCF7L2	TCF-4 \| TCF4	transcription factor 7-like 2 (T-cell specific, HMG-box)	-	HPRD,BioGRID	11711551
WDYHV1	C8orf32 \| FLJ10204	WDYHV motif containing 1	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA	60	47	All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC	76	59	All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY	39	33	All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME ADHERENS JUNCTIONS INTERACTIONS	27	20	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION	56	31	All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION	78	43	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP	450	256	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN	258	141	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN GRANULOCYTE UP	15	9	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP	55	34	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS DN	133	77	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP	316	190	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN	142	95	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP	612	367	All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN	25	13	All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER	178	108	All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY	66	48	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
LIU NASOPHARYNGEAL CARCINOMA	70	38	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN	261	155	All SZGR 2.0 genes in this pathway
WU CELL MIGRATION	184	114	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS	290	172	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS	179	105	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA	69	47	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN	66	47	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
CROMER METASTASIS DN	81	58	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN	246	180	All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA UP	52	33	All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D	79	62	All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C2	25	18	All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1	58	43	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS DN	25	21	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN	96	71	All SZGR 2.0 genes in this pathway
SAFFORD T LYMPHOCYTE ANERGY	87	54	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 9	92	59	All SZGR 2.0 genes in this pathway
KANG CISPLATIN RESISTANCE UP	19	11	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP	317	208	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
MISHRA CARCINOMA ASSOCIATED FIBROBLAST DN	24	13	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
MUELLER COMMON TARGETS OF AML FUSIONS UP	14	10	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN	80	53	All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP	75	47	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE B ALL DN	15	10	All SZGR 2.0 genes in this pathway
DURAND STROMA S UP	297	194	All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS	95	54	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	754	760	1A	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	754	760	1A	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-381	1095	1101	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-9	1103	1109	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: JUP