SZGR2

Summary ?

GeneID	3760
Symbol	KCNJ3
Synonyms	GIRK1\|KGA\|KIR3.1
Description	potassium voltage-gated channel subfamily J member 3
Reference	MIM:601534\|HGNC:HGNC:6264\|Ensembl:ENSG00000162989\|HPRD:03323\|Vega:OTTHUMG00000131937
Gene type	protein-coding
Map location	2q24.1
Pascal p-value	0.049
Fetal beta	-2.018
DMG	1 (# studies)
eGene	Cerebellar Hemisphere Cerebellum Cortex
Support	CANABINOID EXCITABILITY SEROTONIN

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.02395
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg23491599	2	155554688	KCNJ3	8.32E-5	-0.63	0.026	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TTBK1	0.90	0.91
MGAT3	0.87	0.90
NCLN	0.87	0.89
FBXL14	0.86	0.88
AARS2	0.86	0.88
TECPR1	0.86	0.88
MEGF8	0.86	0.88
CRTC1	0.85	0.88
MARK2	0.85	0.87
GAK	0.85	0.86

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.68	-0.66
AF347015.21	-0.68	-0.70
MT-CO2	-0.67	-0.65
AF347015.8	-0.66	-0.65
AL139819.3	-0.65	-0.68
AF347015.33	-0.65	-0.62
AF347015.27	-0.64	-0.65
MT-CYB	-0.64	-0.63
FXYD1	-0.62	-0.60
AC021016.1	-0.62	-0.64

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005244	voltage-gated ion channel activity	IEA		-
GO:0015467	G-protein activated inward rectifier potassium channel activity	TAS		8804710
GO:0030955	potassium ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006811	ion transport	IEA		-
GO:0006813	potassium ion transport	TAS		8804710
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-
GO:0008076	voltage-gated potassium channel complex	TAS		8804710

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
ST G ALPHA I PATHWAY	35	29	All SZGR 2.0 genes in this pathway
ST ADRENERGIC	36	29	All SZGR 2.0 genes in this pathway
ST MYOCYTE AD PATHWAY	27	25	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	25	17	All SZGR 2.0 genes in this pathway
REACTOME GABA B RECEPTOR ACTIVATION	38	26	All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION	52	40	All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS	98	68	All SZGR 2.0 genes in this pathway
REACTOME INWARDLY RECTIFYING K CHANNELS	31	20	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP	390	236	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP	89	51	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4	307	185	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN	258	160	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP	172	109	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP	149	85	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN	264	159	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN	113	76	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL	129	85	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A	182	108	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	604	610	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-142-5p	550	556	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-25/32/92/363/367	229	235	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-30-5p	545	551	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	234	240	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-363	238	244	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-365	16	22	1A	hsa-miR-365	UAAUGCCCCUAAAAAUCCUUAU
miR-369-3p	211	217	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-375	929	935	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-378*	44	50	1A	hsa-miR-422b	CUGGACUUGGAGUCAGAAGGCC
miR-378*	44	50	1A	hsa-miR-422a	CUGGACUUAGGGUCAGAAGGCC
miR-410	271	277	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: KCNJ3