Gene Page: KCNJ3

Summary
GeneID  3760
Symbol  KCNJ3
Synonyms  GIRK1|KGA|KIR3.1
Description  potassium inwardly-rectifying channel, subfamily J, member 3
See related  HGNC:6264|MIM:601534|Ensembl:ENSG00000162989|HPRD:03323|
Locus tag  -
Gene type  protein-coding
Map location  2q24.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TTBK10.900.91
MGAT30.870.90
NCLN0.870.89
FBXL140.860.88
AARS20.860.88
TECPR10.860.88
MEGF80.860.88
CRTC10.850.88
MARK20.850.87
GAK0.850.86
Top 10 negatively co-expressed genes
AF347015.31-0.68-0.66
AF347015.21-0.68-0.70
MT-CO2-0.67-0.65
AF347015.8-0.66-0.65
AL139819.3-0.65-0.68
AF347015.33-0.65-0.62
AF347015.27-0.64-0.65
MT-CYB-0.64-0.63
FXYD1-0.62-0.60
AC021016.1-0.62-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005244voltage-gated ion channel activityIEA-
GO:0015467G-protein activated inward rectifier potassium channel activityTAS8804710 
GO:0030955potassium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006811ion transportIEA-
GO:0006813potassium ion transportTAS8804710 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0008076voltage-gated potassium channel complexTAS8804710 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRB2ADRB2R | ADRBR | B2AR | BAR | BETA2ARadrenergic, beta-2-, receptor, surfaceAffinity Capture-WesternBioGRID12297500 
DRD2D2DR | D2Rdopamine receptor D2Affinity Capture-WesternBioGRID12297500 
DRD4D4DRdopamine receptor D4Affinity Capture-WesternBioGRID12297500 
GNB1-guanine nucleotide binding protein (G protein), beta polypeptide 1Reconstituted ComplexBioGRID12743112 
KCNJ5CIR | GIRK4 | KATP1 | KIR3.4potassium inwardly-rectifying channel, subfamily J, member 5Phenotypic Enhancement
Reconstituted Complex		BioGRID9108307 |11741896 
-HPRD9108307 |9765280 
KCNJ6BIR1 | GIRK2 | KATP2 | KCNJ7 | KIR3.2 | MGC126596 | hiGIRK2potassium inwardly-rectifying channel, subfamily J, member 6-HPRD8929423 |9023358 
KCNJ9GIRK3 | KIR3.3potassium inwardly-rectifying channel, subfamily J, member 9-HPRD12297500 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
ST_G_ALPHA_I_PATHWAY 3529All SZGR genes in this pathway
ST_ADRENERGIC 3629All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY 2725All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS 2517All SZGR genes in this pathway
REACTOME_GABA_B_RECEPTOR_ACTIVATION 3826All SZGR genes in this pathway
REACTOME_GABA_RECEPTOR_ACTIVATION 5240All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS 9868All SZGR genes in this pathway
REACTOME_INWARDLY_RECTIFYING_K_CHANNELS 3120All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_UP 8951All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_DN 11376All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL 12985All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.16046101Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-142-5p550556m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-25/32/92/363/3672292351Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-30-5p545551m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-323234240m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3632382441Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-36516221Ahsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
miR-369-3p211217m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3759299351Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-378*44501Ahsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-4102712771Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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