Gene Page: KIF25

Summary ?
GeneID3834
SymbolKIF25
SynonymsKNSL3
Descriptionkinesin family member 25
ReferenceMIM:603815|HGNC:HGNC:6390|Ensembl:ENSG00000125337|HPRD:04818|Vega:OTTHUMG00000016035
Gene typeprotein-coding
Map location6q27
Pascal p-value0.519
Fetal beta-0.767
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Putamen basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:McCarthy_2014Whole Exome Sequencing analysisWhole exome sequencing of 57 trios with sporadic or familial schizophrenia.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
KIF25chr6168442811CTNM_005355p.S270Lmissense SNVNBSchizophreniaDNM:McCarthy_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10847737chr12129507602KIF2538340.09trans
rs26363566168410364KIF25ENSG00000125337.125.56102E-70.0210592gtex_brain_putamen_basal
rs25168126168410373KIF25ENSG00000125337.121.73906E-60.0210601gtex_brain_putamen_basal
rs25168146168410456KIF25ENSG00000125337.121.74947E-60.0210684gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003777microtubule motor activityIEA-
GO:0005524ATP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000070mitotic sister chromatid segregationTAS9925916 
GO:0007018microtubule-based movementIEA-
GO:0006996organelle organizationTAS9925916 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005871kinesin complexTAS9925916 
GO:0005874microtubuleIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway