Gene Page: LIG4

Summary
GeneID  3981
Symbol  LIG4
Synonyms  -
Description  ligase IV, DNA, ATP-dependent
See related  HGNC:6601|MIM:601837|Ensembl:ENSG00000174405|HPRD:03500|
Locus tag  -
Gene type  protein-coding
Map location  13q33-q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003677DNA bindingIDA8798671 
GO:0003910DNA ligase (ATP) activityIDA8798671 
GO:0005524ATP bindingIC8798671 
GO:0016874ligase activityIDA9242410 
GO:0008022protein C-terminus bindingIPI12589063 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentISSBrain (GO term level: 6)-
GO:0050769positive regulation of neurogenesisISSneuron, neurogenesis (GO term level: 9)-
GO:0043524negative regulation of neuron apoptosisISSneuron (GO term level: 9)-
GO:0000012single strand break repairIDA8798671 
GO:0001701in utero embryonic developmentISS-
GO:0002328pro-B cell differentiationISS-
GO:0006303double-strand break repair via nonhomologous end joiningIDA12517771 
GO:0006303double-strand break repair via nonhomologous end joiningIMP9809069 
GO:0006297nucleotide-excision repair, DNA gap fillingIDA12517771 
GO:0006260DNA replicationIEA-
GO:0007049cell cycleIEA-
GO:0008283cell proliferationISS-
GO:0010165response to X-rayIMP9809069 
GO:0010332response to gamma radiationISS-
GO:0019047provirus integrationEXP16291214 
GO:0019059initiation of viral infectionEXP12091904 
GO:0035019somatic stem cell maintenanceISS-
GO:0033077T cell differentiation in the thymusISS-
GO:0051102DNA ligation during DNA recombinationISS-
GO:0051103DNA ligation during DNA repairIDA12517771 
GO:0051103DNA ligation during DNA repairISS-
GO:0033153T cell receptor V(D)J recombinationISS-
GO:0033152immunoglobulin V(D)J recombinationIEA-
GO:0051276chromosome organizationISS-
GO:0051301cell divisionIEA-
GO:0045190isotype switchingISS-
GO:0048146positive regulation of fibroblast proliferationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000793condensed chromosomeIDA12589063 
GO:0005622intracellularIEA-
GO:0005634nucleusIDA8798671 |12589063 
GO:0005737cytoplasmIDA18029348 
GO:0005925focal adhesionIDA18029348 
GO:0005958DNA-dependent protein kinase complexISS-
GO:0005886plasma membraneIDA18029348 
GO:0032807DNA ligase IV complexIMP9809069 
GO:0032807DNA ligase IV complexIPI9242410 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedProtein-peptideBioGRID10608806 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedProtein-peptideBioGRID10608806 
NHEJ1FLJ12610 | XLFnonhomologous end-joining factor 1Affinity Capture-WesternBioGRID17567543 
PNKPPNKpolynucleotide kinase 3'-phosphataseAffinity Capture-MSBioGRID17353931 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptideProtein-peptideBioGRID10608806 
XRCC4-X-ray repair complementing defective repair in Chinese hamster cells 4DNA Ligase IV (LIG4) interacts with XRCC4.BIND9242410 
Affinity Capture-Western
Co-crystal Structure
Two-hybrid		BioGRID11702069 |17567543 
-HPRD10854421 
 


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