Gene Page: LPA
Summary ?
GeneID | 4018 |
Symbol | LPA |
Synonyms | AK38|APOA|LP |
Description | lipoprotein, Lp(a) |
Reference | MIM:152200|HGNC:HGNC:6667|Ensembl:ENSG00000198670|HPRD:01063|Vega:OTTHUMG00000015956 |
Gene type | protein-coding |
Map location | 6q26 |
Pascal p-value | 0.601 |
Fetal beta | 0.111 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizotypy,schizophrenias,schizotypal | Click to show details |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
PDE1B | 0.87 | 0.88 |
RAP1GAP | 0.86 | 0.84 |
HPCA | 0.84 | 0.79 |
RASD2 | 0.84 | 0.85 |
ADRA2C | 0.84 | 0.69 |
TESC | 0.83 | 0.75 |
AC005512.1 | 0.83 | 0.64 |
LINGO3 | 0.82 | 0.73 |
RGS14 | 0.82 | 0.81 |
KCNAB1 | 0.82 | 0.79 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AC132872.1 | -0.35 | -0.46 |
KCNMB3 | -0.33 | -0.36 |
KIAA1949 | -0.32 | -0.26 |
RBMX2 | -0.31 | -0.44 |
ZNF300 | -0.31 | -0.15 |
AC005921.3 | -0.31 | -0.52 |
ZNF311 | -0.31 | -0.22 |
TUBB2B | -0.31 | -0.35 |
AC005768.1 | -0.30 | -0.33 |
SH3BP2 | -0.30 | -0.40 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0004252 | serine-type endopeptidase activity | IEA | glutamate (GO term level: 7) | - |
GO:0005509 | calcium ion binding | IEA | - | |
GO:0004866 | endopeptidase inhibitor activity | TAS | 8047165 | |
GO:0008233 | peptidase activity | IEA | - | |
GO:0034185 | apolipoprotein binding | IPI | 9269765 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0006508 | proteolysis | IEA | - | |
GO:0008015 | blood circulation | TAS | 8047165 | |
GO:0007596 | blood coagulation | IEA | - | |
GO:0006629 | lipid metabolic process | NAS | 8047165 | |
GO:0006869 | lipid transport | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005576 | extracellular region | EXP | 9548923 | |
GO:0005576 | extracellular region | NAS | 14718574 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
ST GA13 PATHWAY | 37 | 32 | All SZGR 2.0 genes in this pathway |
PID AMB2 NEUTROPHILS PATHWAY | 41 | 32 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | 46 | 37 | All SZGR 2.0 genes in this pathway |
REACTOME LIPOPROTEIN METABOLISM | 28 | 24 | All SZGR 2.0 genes in this pathway |
HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
SU LIVER | 55 | 32 | All SZGR 2.0 genes in this pathway |
LEE LIVER CANCER | 49 | 29 | All SZGR 2.0 genes in this pathway |
CAMPS COLON CANCER COPY NUMBER DN | 74 | 34 | All SZGR 2.0 genes in this pathway |
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP | 85 | 50 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
NABA ECM REGULATORS | 238 | 125 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |