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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: CSNK2A1

Summary

GeneID

1457

Symbol

CSNK2A1

Synonyms

CK2A1|CKII

Description

casein kinase 2, alpha 1 polypeptide

Locus tag

Gene type

protein-coding

Map location

20p13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]

Click to show detail

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.6661

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ACOT7

0.76

0.72

RABGGTA

0.75

ATP13A2

0.74

0.71

SLC5A2

0.74

0.78

NR2F6

0.74

TSPAN17

0.74

0.67

C20orf100

0.73

0.69

CSDC2

0.73

0.75

FSD1

0.73

0.70

HPS1

0.73

0.71

Top 10 negatively co-expressed genes

AF347015.21

-0.48

-0.40

MT-ATP8

-0.46

-0.42

AF347015.8

-0.45

-0.36

AF347015.31

-0.43

-0.36

AF347015.2

-0.42

-0.33

MT-CO2

-0.42

-0.34

AF347015.18

-0.42

-0.36

MT-CYB

-0.42

-0.35

AF347015.27

-0.42

-0.36

AF347015.33

-0.41

-0.34

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005524

ATP binding

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0004674

protein serine/threonine kinase activity

TAS

2174700

GO:0016740

transferase activity

IEA

GO:0019888

protein phosphatase regulator activity

IEA

GO:0008013

beta-catenin binding

IEA

GO:0047485

protein N-terminus binding

IPI

11972058

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006468

protein amino acid phosphorylation

TAS

2174700

GO:0016055

Wnt receptor signaling pathway

IEA

GO:0007165

signal transduction

TAS

2174700

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

TAS

10799509

GO:0005886

plasma membrane

TAS

10799509

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	CK2 interacts with and phosphorylates Akt. This interaction was modeled on a demonstrated interaction between human CK2 and Akt from an unspecified species and mouse.	BIND	15818404
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	Affinity Capture-Western Reconstituted Complex	BioGRID	11972058
ARR3	ARRX	arrestin 3, retinal (X-arrestin)	-	HPRD,BioGRID	11877451
ARRB1	ARB1 \| ARR1	arrestin, beta 1	Affinity Capture-MS	BioGRID	17353931
ATF1	EWS-ATF1 \| FUS/ATF-1 \| TREB36	activating transcription factor 1	-	HPRD,BioGRID	9685505
ATF2	CRE-BP1 \| CREB2 \| HB16 \| MGC111558 \| TREB7	activating transcription factor 2	-	HPRD,BioGRID	9685505
BDP1	DKFZp686C01233 \| DKFZp686K0831 \| HSA238520 \| KIAA1241 \| KIAA1689 \| TAF3B1 \| TFC5 \| TFIIIB'' \| TFIIIB150 \| TFIIIB90 \| TFNR	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	CK2alpha interacts with Bdp1.	BIND	15469824
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	10403822
BRF1	BRF \| FLJ42674 \| FLJ43034 \| GTF3B \| MGC105048 \| TAF3B2 \| TAF3C \| TAFIII90 \| TF3B90 \| TFIIIB90 \| hBRF	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	-	HPRD,BioGRID	11997511
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	12527891
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	-	HPRD	11255227
CFDP1	BCNT \| BUCENTAUR \| CP27 \| SWC5 \| Yeti \| p97	craniofacial development protein 1	-	HPRD	10350657
CHEK1	CHK1	CHK1 checkpoint homolog (S. pombe)	Affinity Capture-Western Reconstituted Complex	BioGRID	12902976 \|15225637
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	-	HPRD,BioGRID	9685505
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-alpha subunit (PDB ID: 1JWH_A).	BIND	11092945 \|11574463
			Interaction between CK2-beta subunit (PDB ID: 1JWH_C) and CK2-alpha subunit (PDB ID: 1JWH_B).	BIND	11092945 \|11574463
			Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-alpha subunit (PDB ID: 1JWH_B).	BIND	11092945 \|11574463
			-	HPRD,BioGRID	9188720 \|9571630
			Interaction between CK2-beta subunit (PDB ID: 1JWH_C) and CK2-alpha subunit (PDB ID: 1JWH_A).	BIND	11092945 \|11574463
			CK2-alpha subunit interacts with CK2-beta subunit.	BIND	7768894
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD	12432063
DDIT3	CEBPZ \| CHOP \| CHOP10 \| GADD153 \| MGC4154	DNA-damage-inducible transcript 3	-	HPRD,BioGRID	12876286
DVL1	DVL \| MGC54245	dishevelled, dsh homolog 1 (Drosophila)	-	HPRD,BioGRID	10806215
DVL2	-	dishevelled, dsh homolog 2 (Drosophila)	Affinity Capture-Western	BioGRID	10806215
DVL3	KIAA0208	dishevelled, dsh homolog 3 (Drosophila)	-	HPRD,BioGRID	10806215
EEF1D	EF-1D \| EF1D \| FLJ20897 \| FP1047	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	-	HPRD,BioGRID	10094407
EIF2S2	DKFZp686L18198 \| EIF2 \| EIF2B \| EIF2beta \| MGC8508	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	EIF2beta interacts with CK2alpha.	BIND	12901717
FGF1	AFGF \| ECGF \| ECGF-beta \| ECGFA \| ECGFB \| FGF-alpha \| FGFA \| GLIO703 \| HBGF1	fibroblast growth factor 1 (acidic)	-	HPRD,BioGRID	12145206
FGF2	BFGF \| FGFB \| HBGF-2	fibroblast growth factor 2 (basic)	-	HPRD,BioGRID	12145206
FIBP	FGFIBP \| FIBP-1	fibroblast growth factor (acidic) intracellular binding protein	-	HPRD	12145206
FLG	ATOD2	filaggrin	-	HPRD	8270625
FOS	AP-1 \| C-FOS	v-fos FBJ murine osteosarcoma viral oncogene homolog	-	HPRD,BioGRID	9685505
GABRR2	-	gamma-aminobutyric acid (GABA) receptor, rho 2	-	HPRD	12175859
GDNF	ATF1 \| ATF2 \| HFB1-GDNF	glial cell derived neurotrophic factor	-	HPRD	9685505
HCLS1	CTTNL \| HS1	hematopoietic cell-specific Lyn substrate 1	Biochemical Activity	BioGRID	11988074
HDAC2	RPD3 \| YAF1	histone deacetylase 2	-	HPRD,BioGRID	12176973
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	CSNK2A1 (CK2) phosphorylates HDAC3.	BIND	15805470
HNRNPA2B1	DKFZp779B0244 \| FLJ22720 \| HNRNPA2 \| HNRNPB1 \| HNRPA2 \| HNRPA2B1 \| HNRPB1 \| RNPA2 \| SNRPB1	heterogeneous nuclear ribonucleoprotein A2/B1	-	HPRD,BioGRID	10381337
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	7794926
HSP90B1	ECGP \| GP96 \| GRP94 \| TRA1	heat shock protein 90kDa beta (Grp94), member 1	-	HPRD,BioGRID	11557039
IRF1	IRF-1 \| MAR	interferon regulatory factor 1	An unspecified isoform of CK2-alpha interacts with IRF-1 promoter.	BIND	15893730
IRF2	DKFZp686F0244 \| IRF-2	interferon regulatory factor 2	-	HPRD,BioGRID	9213219
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD,BioGRID	9685505
KLF1	EKLF	Kruppel-like factor 1 (erythroid)	-	HPRD,BioGRID	9722526
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	Affinity Capture-Western Reconstituted Complex	BioGRID	10747897
MAZ	PUR1 \| Pur-1 \| SAF-1 \| SAF-2 \| ZF87 \| ZNF801 \| Zif87	MYC-associated zinc finger protein (purine-binding transcription factor)	Biochemical Activity	BioGRID	10448092
MGMT	-	O-6-methylguanine-DNA methyltransferase	-	HPRD,BioGRID	10667577
MME	CALLA \| CD10 \| DKFZp686O16152 \| MGC126681 \| MGC126707 \| NEP	membrane metallo-endopeptidase	Biochemical Activity	BioGRID	8943850
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	CK2 interacts with and phosphorylates c-Myc. This interaction was modelled on a demonstrated interaction between mouse CK2 and human c-Myc.	BIND	12149649
NAP1L4	MGC4565 \| NAP2 \| NAP2L \| hNAP2	nucleosome assembly protein 1-like 4	-	HPRD	10764593
NCL	C23 \| FLJ45706	nucleolin	-	HPRD	2192260\|8663258
OGT	FLJ23071 \| HRNT1 \| MGC22921 \| O-GLCNAC	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	-	HPRD	10753899
PAFAH1B1	LIS1 \| LIS2 \| MDCR \| MDS \| PAFAH	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa	-	HPRD,BioGRID	10491172
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD	10938077
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	-	HPRD,BioGRID	11940573
PLEKHO1	CKIP-1 \| OC120	pleckstrin homology domain containing, family O member 1	-	HPRD,BioGRID	10799509
PPP2R4	MGC2184 \| PP2A \| PR53 \| PTPA	protein phosphatase 2A activator, regulatory subunit 4	-	HPRD	9139659
PRNP	ASCR \| CD230 \| CJD \| GSS \| MGC26679 \| PRIP \| PrP \| PrP27-30 \| PrP33-35C \| PrPc \| prion	prion protein	PrPc interacts with CSNK2A1 (CK2 alpha). This interaction was modeled on a demonstrated interaction between bovine PrPc and human CSNK2A1 (CK2 alpha).	BIND	11062072
PSMA4	HC9 \| HsT17706 \| MGC111191 \| MGC12467 \| MGC24813 \| PSC9	proteasome (prosome, macropain) subunit, alpha type, 4	-	HPRD,BioGRID	8619999
PTEN	10q23del \| BZS \| MGC11227 \| MHAM \| MMAC1 \| PTEN1 \| TEP1	phosphatase and tensin homolog	-	HPRD,BioGRID	12297295
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	10938077
RNPS1	E5.1 \| MGC117332	RNA binding protein S1, serine-rich domain	Affinity Capture-MS	BioGRID	17353931
RPL5	MGC117339 \| MSTP030	ribosomal protein L5	-	HPRD,BioGRID	10491318
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	Reconstituted Complex	BioGRID	16895915
SFN	YWHAS	stratifin	Affinity Capture-MS	BioGRID	15778465
SFRS12	DKFZp564B176 \| MGC133045 \| SRrp508 \| SRrp86	splicing factor, arginine/serine-rich 12	-	HPRD	14559993
SPI1	OF \| PU.1 \| SFPI1 \| SPI-1 \| SPI-A	spleen focus forming virus (SFFV) proviral integration oncogene spi1	Biochemical Activity	BioGRID	8632909
SPIB	SPI-B	Spi-B transcription factor (Spi-1/PU.1 related)	-	HPRD,BioGRID	8632909
TAF7	TAF2F \| TAFII55	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	CK2-alpha interacts with TAF7 promoter.	BIND	15893730
TOP1	TOPI	topoisomerase (DNA) I	-	HPRD,BioGRID	2998765
UBTF	NOR-90 \| UBF	upstream binding transcription factor, RNA polymerase I	-	HPRD,BioGRID	7651819
VAMP4	VAMP24	vesicle-associated membrane protein 4	Biochemical Activity	BioGRID	14608369
XK	KX \| X1k \| XKR1	X-linked Kx blood group (McLeod syndrome)	-	HPRD,BioGRID	9647734
XKRY	XKRY1	XK, Kell blood group complex subunit-related, Y-linked	Biochemical Activity	BioGRID	9647734
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	Affinity Capture-MS	BioGRID	17353931
ZHX1	-	zinc fingers and homeoboxes 1	Two-hybrid	BioGRID	16169070

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	212	218	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	212	218	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-141/200a	1219	1225	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1219	1225	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-186	1229	1235	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-23	1207	1213	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1207	1213	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-30-3p	225	231	1A	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	225	231	1A	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-326	425	431	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-329	1176	1182	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-331	214	220	1A	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-375	306	312	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-411	102	108	m8	hsa-miR-411	AACACGGUCCACUAACCCUCAGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.