Gene Page: MCL1

Summary
GeneID  4170
Symbol  MCL1
Synonyms  BCL2L3|EAT|MCL1L|MCL1S|MGC104264|MGC1839|TM
Description  myeloid cell leukemia sequence 1 (BCL2-related)
See related  HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|
Locus tag  -
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIDA10837489 
GO:0015266protein channel activityTAS10837489 
GO:0046982protein heterodimerization activityIPI10837489 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001709cell fate determinationNAS10837489 
GO:0006916anti-apoptosisTAS10837489 
GO:0008632apoptotic programTAS7682708 
GO:0007275multicellular organismal developmentTAS8790944 
GO:0019725cellular homeostasisNAS10837489 
GO:0042981regulation of apoptosisIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmTAS10837489 
GO:0005739mitochondrionIEA-
GO:0005741mitochondrial outer membraneTAS10837489 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BADBBC2 | BCL2L8BCL2-associated agonist of cell death-HPRD10579309 |10837489 
Protein-peptide
Reconstituted Complex
Two-hybrid
BioGRID11483855 |15694340 
BAK1BAK | BAK-LIKE | BCL2L7 | CDN1 | MGC117255 | MGC3887BCL2-antagonist/killer 1-HPRD10579309 |10837489 
Affinity Capture-Western
Protein-peptide
Reconstituted Complex
Two-hybrid
BioGRID10837489 |15077116 
|15637055 |15901672 
BAXBCL2L4BCL2-associated X protein-HPRD,BioGRID10837489 
BBC3JFY1 | PUMABCL2 binding component 3Affinity Capture-WesternBioGRID15694340 
Mcl-1 interacts with Puma. This interaction was modelled on a demonstrated interaction between Mcl-1 from an unspecified species and human Puma.BIND15721256 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1Affinity Capture-WesternBioGRID10837489 
BCL2L11BAM | BIM | BIM-alpha6 | BIM-beta6 | BIM-beta7 | BOD | BimEL | BimLBCL2-like 11 (apoptosis facilitator)-HPRD,BioGRID10837489 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonistAffinity Capture-Western
Protein-peptide
Reconstituted Complex
BioGRID15637055 |15694340 
BIKBIP1 | BP4 | NBKBCL2-interacting killer (apoptosis-inducing)Protein-peptideBioGRID15694340 
BMFFLJ00065Bcl2 modifying factorProtein-peptideBioGRID15694340 
Mcl-1 interacts with Bmf. This interaction was modelled on a demonstrated interaction between Mcl-1 from an unspecified species and human Bmf.BIND15721256 
BOKBCL2L9 | BOKL | MGC4631BCL2-related ovarian killer-HPRD,BioGRID9356461 |10579309 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID15637055 
DAD1OST2defender against cell death 1Affinity Capture-Western
Two-hybrid
BioGRID10965038 
HRKDP5 | HARAKIRIharakiri, BCL2 interacting protein (contains only BH3 domain)Protein-peptideBioGRID15694340 
HUWE1ARF-BP1 | HECTH9 | HSPC272 | Ib772 | KIAA0312 | LASU1 | MULE | UREB1HECT, UBA and WWE domain containing 1Mule interacts with and ubiquitinates Mcl-1.BIND15989957 
IER3DIF-2 | DIF2 | GLY96 | IEX-1 | IEX-1L | IEX1 | PRG1immediate early response 3An unspecified isoform of IEX-1 interacts with MCL1.BIND15451437 
MCL1BCL2L3 | EAT | MCL1L | MCL1S | MGC104264 | MGC1839 | TMmyeloid cell leukemia sequence 1 (BCL2-related)-HPRD,BioGRID10837489 
PCNAMGC8367proliferating cell nuclear antigenAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID10978339 
PMAIP1APR | NOXAphorbol-12-myristate-13-acetate-induced protein 1-HPRD,BioGRID15694340 
TNKSPARP-5a | PARP5A | PARPL | TIN1 | TINF1 | TNKS1tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase-HPRD,BioGRID12475993 
TPT1FLJ27337 | HRF | TCTP | p02tumor protein, translationally-controlled 1-HPRD11598139 |12149273 
VDAC1MGC111064 | PORIN | PORIN-31-HLvoltage-dependent anion channel 1Reconstituted ComplexBioGRID15637055 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-125/351260226091A,m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-133271327191Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-142-5p22172223m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-153905911m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d221522221A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-181207520811Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1933163231A,m8hsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-25/32/92/363/367181A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-26599605m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-29131813251A,m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-320800806m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-493-5p26352641m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-504199119971Ahsa-miR-504AGACCCUGGUCUGCACUCUAU
miR-93.hd/291-3p/294/295/302/372/373/52022142220m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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