Gene Page: SMCP
Summary ?
| GeneID | 4184 |
| Symbol | SMCP |
| Synonyms | HSMCSGEN1|MCS|MCSP |
| Description | sperm mitochondria associated cysteine rich protein |
| Reference | MIM:601148|HGNC:HGNC:6962|Ensembl:ENSG00000163206|HPRD:03093|Vega:OTTHUMG00000012452 |
| Gene type | protein-coding |
| Map location | 1q21.3 |
| Sherlock p-value | 0.49 |
| Fetal beta | -0.14 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere Cerebellum |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0235 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.00814 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg20951266 | 1 | 152856288 | SMCP | 3.905E-4 | -0.359 | 0.043 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CNNM1 | 0.93 | 0.93 |
| CLSTN1 | 0.92 | 0.92 |
| LRP11 | 0.92 | 0.93 |
| SLC8A2 | 0.92 | 0.93 |
| SLC6A17 | 0.92 | 0.92 |
| BSN | 0.92 | 0.92 |
| PIP5K1C | 0.91 | 0.93 |
| ANKRD34A | 0.91 | 0.91 |
| IQSEC2 | 0.91 | 0.87 |
| TSPYL1 | 0.91 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DBI | -0.47 | -0.54 |
| GNG11 | -0.45 | -0.52 |
| MYL12A | -0.44 | -0.52 |
| RAB13 | -0.42 | -0.52 |
| C1orf54 | -0.42 | -0.49 |
| C1orf61 | -0.42 | -0.51 |
| C8orf59 | -0.42 | -0.40 |
| PECI | -0.42 | -0.45 |
| GTF3C6 | -0.41 | -0.36 |
| C21orf57 | -0.41 | -0.40 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003674 | molecular_function | ND | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007339 | binding of sperm to zona pellucida | IEA | - | |
| GO:0007341 | penetration of zona pellucida | ISS | - | |
| GO:0030317 | sperm motility | ISS | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | ISS | - | |
| GO:0005739 | mitochondrion | ISS | - | |
| GO:0016020 | membrane | IEA | - | |
| GO:0031966 | mitochondrial membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SU TESTIS | 76 | 53 | All SZGR 2.0 genes in this pathway |
| CHANG IMMORTALIZED BY HPV31 DN | 65 | 45 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D UP | 210 | 124 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K9ME3 UP | 141 | 75 | All SZGR 2.0 genes in this pathway |
| MATZUK SPERMATOZOA | 114 | 77 | All SZGR 2.0 genes in this pathway |
| MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| MAEKAWA ATF2 TARGETS | 24 | 19 | All SZGR 2.0 genes in this pathway |