Gene Page: MET

Summary
GeneID  4233
Symbol  MET
Synonyms  AUTS9|HGFR|RCCP2|c-Met
Description  met proto-oncogene (hepatocyte growth factor receptor)
See related  HGNC:7029|MIM:164860|Ensembl:ENSG00000105976|HPRD:01280|
Locus tag  -
Gene type  protein-coding
Map location  7q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.5697 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ACOT130.760.78
DYRK40.710.69
MTCP1NB0.700.68
SERPINB60.700.73
LGALS10.690.76
EAF20.690.75
TMEM220.690.68
AC007405.80.690.70
VAMP80.690.71
GMFG0.690.71
Top 10 negatively co-expressed genes
AD000671.1-0.62-0.72
POGZ-0.62-0.69
TNKS1BP1-0.62-0.69
PHF12-0.62-0.70
MLL5-0.62-0.67
PIK3C2B-0.62-0.71
SEMA4C-0.62-0.70
TCF20-0.62-0.70
CHD3-0.62-0.70
RBM33-0.62-0.70
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005008hepatocyte growth factor receptor activityTAS10871856 
GO:0004872receptor activityIEA-
GO:0005515protein bindingIPI11571281 
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007166cell surface receptor linked signal transductionNAS2819873 
GO:0008283cell proliferationTAS10871856 
GO:0007275multicellular organismal developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0009925basal plasma membraneIDA15314156 
GO:0005887integral to plasma membraneTAS1846706 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAG1RAP46BCL2-associated athanogene-HPRD8947043 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceMet interacts with Cbl.BIND11894096 
-HPRD,BioGRID11894096 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)Affinity Capture-WesternBioGRID11254878 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID11254878 
GAB1-GRB2-associated binding protein 1-HPRD10995442 
Met interacts with Gab1.BIND11894096 
GLMNFAP | FAP48 | FAP68 | FKBPAP | GLML | GVM | VMGLOMglomulin, FKBP associated protein-HPRD,BioGRID11571281 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID7511210 |8662889 
|9660480 
HGFF-TCF | HGFB | HPTA | SFhepatocyte growth factor (hepapoietin A; scatter factor)-HPRD,BioGRID1655405 
HGF interacts with Met.BIND15161915 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrate-HPRD8380735 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDaMET (c-Met) interacts with INPP5D (SHIP-1). This interaction was modeled on a demonstrated interaction between human c-Met and SHIP-1 from an unspecified species.BIND15735664 
INPPL1SHIP2inositol polyphosphate phosphatase-like 1MET (c-Met) interacts with INPPL1. This interaction was modeled on a demonstrated interaction between human c-Met and PIK3R1 from an unspecified species.BIND15735664 
METAUTS9 | HGFR | RCCP2 | c-Metmet proto-oncogene (hepatocyte growth factor receptor)The MET receptor dimerizes.BIND15261143 
MUC20FLJ14408 | KIAA1359mucin 20, cell surface associated-HPRD15314156 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)MET (c-Met) interacts with PIK3R1. This interaction was modeled on a demonstrated interaction between human c-Met and PIK3R1 from an unspecified species.BIND15735664 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD8662733 
RANBP10FLJ31165 | KIAA1464RAN binding protein 10-HPRD,BioGRID14684163 
RANBP9RANBPMRAN binding protein 9-HPRD,BioGRID12147692 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1-HPRD,BioGRID11894096 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD7731718 
Affinity Capture-WesternBioGRID9660480 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)Affinity Capture-WesternBioGRID9660480 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID9837958 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID9440692 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206814820m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-101143014361Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-144143014361Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-23206520721A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-323206520711Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-34/4495157m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-34b5258m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-409-3p498504m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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