Gene Page: MGMT

Summary
GeneID  4255
Symbol  MGMT
Synonyms  -
Description  O-6-methylguanine-DNA methyltransferase
See related  HGNC:7059|MIM:156569|Ensembl:ENSG00000170430|HPRD:01135|
Locus tag  RP11-109A6.1
Gene type  protein-coding
Map location  10q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03487 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingTAS2188979 
GO:0003908methylated-DNA-[protein]-cysteine S-methyltransferase activityEXP8434121 
GO:0003908methylated-DNA-[protein]-cysteine S-methyltransferase activityIEA-
GO:0004197cysteine-type endopeptidase activityIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0009008DNA-methyltransferase activityTAS2405387 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006307DNA dealkylationIEA-
GO:0006508proteolysisIEA-
GO:0006266DNA ligationTAS2188979 
GO:0043281regulation of caspase activityIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS2188979 
GO:0005654nucleoplasmEXP8434121 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID11564893 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD,BioGRID10667577 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptideBiochemical ActivityBioGRID10667577 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID11564893 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID11564893 
HIST4H4H4/p | MGC24116histone cluster 4, H4HIST4H4 (H4) interacts with the MGMT promoter.BIND15765097 
PRKACAMGC102831 | MGC48865 | PKACAprotein kinase, cAMP-dependent, catalytic, alpha-HPRD,BioGRID10667577 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alphaBiochemical ActivityBioGRID10667577 
UBA1A1S9 | A1S9T | A1ST | AMCX1 | GXP1 | MGC4781 | SMAX2 | UBA1A | UBE1 | UBE1Xubiquitin-like modifier activating enzyme 1-HPRD8573590 
 


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