Gene Page: MIP

Summary ?
GeneID4284
SymbolMIP
SynonymsAQP0|CTRCT15|LIM1|MIP26|MP26
Descriptionmajor intrinsic protein of lens fiber
ReferenceMIM:154050|HGNC:HGNC:7103|Ensembl:ENSG00000135517|HPRD:01098|Vega:OTTHUMG00000170571
Gene typeprotein-coding
Map location12q13
Pascal p-value0.002
Fetal beta-0.095
eGeneCerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0024 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705MIP42840.07trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005524ATP bindingIEA-
GO:0004672protein kinase activityIEA-
GO:0005212structural constituent of eye lensIEA-
GO:0005215transporter activityTAS1840563 
GO:0015250water channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002088lens development in camera-type eyeIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007601visual perceptionIEA-
GO:0006833water transportIEA-
GO:0006810transportIEA-
GO:0050896response to stimulusIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005921gap junctionIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1840563 
GO:0030054cell junctionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME PASSIVE TRANSPORT BY AQUAPORINS 117All SZGR 2.0 genes in this pathway
REACTOME AQUAPORIN MEDIATED TRANSPORT 5134All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 14280All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-181255261m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1861021081Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-3631952011Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-3771571641A,m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-452196202m8hsa-miR-452UGUUUGCAGAGGAAACUGAGAC