Gene Page: MLLT4

Summary
GeneID  4301
Symbol  MLLT4
Synonyms  AF-6|AF6|AFADIN|FLJ34371|RP3-431P23.3
Description  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
See related  HGNC:7137|MIM:159559|Ensembl:ENSG00000130396|HPRD:01164|
Locus tag  RP3-470B24.4
Gene type  protein-coding
Map location  6q27
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
IGF20.530.43
COL1A10.500.35
COL6A30.500.43
ITIH20.500.40
SLC6A200.500.39
SLC6A40.490.38
ALX40.480.35
TBX150.470.33
OSR10.470.34
LILRB50.470.41
Top 10 negatively co-expressed genes
GLIPR1L2-0.17-0.15
AL139819.3-0.15-0.09
AC007216.4-0.15-0.11
SPINK2-0.14-0.10
C4orf48-0.14-0.15
C6orf54-0.13-0.04
AC131097.1-0.13-0.04
AL353354.3-0.12-0.12
AC008670.2-0.12-0.14
AL512631.1-0.12-0.04
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND10382971 
GO:0005515protein bindingIEA-
GO:0008022protein C-terminus bindingTAS10856295 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionTAS10856295 
GO:0007267cell-cell signalingTAS8242616 
GO:0007165signal transductionIEA-
GO:0007165signal transductionTAS8242616 
GO:0008150biological_processND10382971 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND10382971 
GO:0005911cell-cell junctionTAS10856295 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster region-HPRD,BioGRID12808105 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDa-HPRD,BioGRID11907041 
EPHA7EHK3 | HEK11EPH receptor A7-HPRD,BioGRID9707552 
EphA7 interacts with AF6. This interaction was modelled on a demonstrated interaction between human EphB6 and AF6 from an unspecified species.BIND9707552 
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2EphB2 interacts with AF6. This interaction was modelled on a demonstrated interaction between EphB2 from human and mouse AF6.BIND9707552 
-HPRD,BioGRID9707552 
EPHB3ETK2 | HEK2 | TYRO6EPH receptor B3EphB3 interacts with AF6. This interaction was modelled on a demonstrated interaction between EphB3 from human and mouse AF6.BIND9707552 
-HPRD,BioGRID9707552 
EPHB6HEP | MGC129910 | MGC129911EPH receptor B6EphB6 interacts with AF6. This interaction was modelled on a demonstrated interaction between EphB6 from mouse and AF6 from an unspecified species.BIND9707552 
-HPRD,BioGRID9707552 
F11RCD321 | JAM | JAM-1 | JAM-A | JAM1 | JAMA | JCAM | KAT | PAM-1F11 receptor-HPRD,BioGRID10856295 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD,BioGRID10922060 
JAG1AGS | AHD | AWS | CD339 | HJ1 | JAGL1 | MGC104644jagged 1 (Alagille syndrome)Two-hybridBioGRID9707552 
LMO2RBTN2 | RBTNL1 | RHOM2 | TTG2LIM domain only 2 (rhombotin-like 1)-HPRD,BioGRID12067721 
MRASFLJ42964 | M-RAs | R-RAS3 | RRAS3muscle RAS oncogene homolog-HPRD10446149 
NRASALPS4 | N-ras | NRAS1neuroblastoma RAS viral (v-ras) oncogene homologAffinity Capture-WesternBioGRID12808105 
NRXN1DKFZp313P2036 | FLJ35941 | Hs.22998 | KIAA0578neurexin 1Two-hybridBioGRID9707552 
NRXN2FLJ40892 | KIAA0921neurexin 2-HPRD,BioGRID9707552 
NRXN3KIAA0743 | MGC176711neurexin 3-HPRD,BioGRID9707552 
PFN1-profilin 1-HPRD,BioGRID10922060 
PVRL1CD111 | CLPED1 | ED4 | HIgR | HVEC | MGC142031 | MGC16207 | OFC7 | PRR | PRR1 | PVRR | PVRR1 | SK-12 | nectin-1poliovirus receptor-related 1 (herpesvirus entry mediator C)-HPRD,BioGRID10225955 |10617658 
PVRL2CD112 | HVEB | PRR2 | PVRR2poliovirus receptor-related 2 (herpesvirus entry mediator B)-HPRD10733589 
Affinity Capture-WesternBioGRID10617658 
PVRL3CD113 | CDw113 | DKFZp566B0846 | FLJ90624 | PPR3 | PRR3 | PVRR3 | nectin-3poliovirus receptor-related 3-HPRD,BioGRID10744716 |11024295 
PVRL4LNIR | PRR4 | nectin-4poliovirus receptor-related 4-HPRD11544254 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene family-HPRD,BioGRID10224125 |10922060|10922060 
RAP1GAPKIAA0474 | RAP1GA1 | Rap1GAP1 | rap1GAPIIRAP1 GTPase activating protein-HPRD,BioGRID12590145 
RAP2AK-REV | KREV | RAP2 | RbBP-30RAP2A, member of RAS oncogene family-HPRD10224125 
RIN1-Ras and Rab interactor 1Two-hybridBioGRID10545207 
RIT1MGC125864 | MGC125865 | RIBB | RIT | ROC1Ras-like without CAAX 1-HPRD,BioGRID10545207 
RIT2RIBA | RIN | ROC2Ras-like without CAAX 2-HPRD10545207 
RRAS-related RAS viral (r-ras) oncogene homolog-HPRD10224125 
RRAS2TC21related RAS viral (r-ras) oncogene homolog 2-HPRD,BioGRID10224125 |11788587 
SORBS1CAP | DKFZp451C066 | DKFZp586P1422 | FLAF2 | FLJ12406 | KIAA1296 | R85FL | SH3D5 | SH3P12 | SORB1sorbin and SH3 domain containing 1-HPRD,BioGRID10085297 |10583506 
SORBS2ARGBP2 | FLJ93447 | KIAA0777 | PRO0618sorbin and SH3 domain containing 2-HPRD,BioGRID10521485 
SSX2IPADIP | FLJ10848 | KIAA0923 | MGC75026synovial sarcoma, X breakpoint 2 interacting protein-HPRD,BioGRID12446711 
TJP1DKFZp686M05161 | MGC133289 | ZO-1tight junction protein 1 (zona occludens 1)-HPRD,BioGRID10334923 
USP9XDFFRX | FAF | FAMubiquitin specific peptidase 9, X-linked-HPRD,BioGRID9722616 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideAffinity Capture-MSBioGRID17353931 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID17353931 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideAffinity Capture-MSBioGRID17353931 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98158164m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-13923702376m8hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-493-5p24032409m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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