Gene Page: FOXO4

Summary
GeneID  4303
Symbol  FOXO4
Synonyms  AFX|AFX1|MGC120490|MLLT7
Description  forkhead box O4
See related  HGNC:7139|MIM:300033|Ensembl:ENSG00000184481|HPRD:02070|
Locus tag  -
Gene type  protein-coding
Map location  Xq13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0217 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
METTL7A0.930.92
GRAMD30.920.87
RANBP3L0.890.86
MRO0.890.83
KAT2B0.880.88
HTRA10.880.89
HEPACAM0.870.90
CHDH0.870.89
ALDH1L10.860.83
PMP20.860.87
Top 10 negatively co-expressed genes
MED19-0.55-0.64
AC011491.1-0.55-0.65
NR2C2AP-0.53-0.63
STMN2-0.53-0.57
CRMP1-0.53-0.54
DPF1-0.52-0.55
ZNF821-0.52-0.55
MPP3-0.52-0.54
PPP3CC-0.52-0.57
STMN1-0.52-0.57
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA10783894 
GO:0008134transcription factor bindingIPI16054032 
GO:0016563transcription activator activityIEA-
GO:0019899enzyme bindingIPI15126506 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007519skeletal muscle developmentIEAneuron (GO term level: 8)-
GO:0000080G1 phase of mitotic cell cycleIDA10783894 
GO:0006355regulation of transcription, DNA-dependentIDA15126506 
GO:0006366transcription from RNA polymerase II promoterTAS10783894 
GO:0007049cell cycleIEA-
GO:0007050cell cycle arrestIDA10783894 
GO:0007095mitotic cell cycle G2/M transition DNA damage checkpointIEA-
GO:0008285negative regulation of cell proliferationIDA10783894 
GO:0008286insulin receptor signaling pathwayIDA10217147 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0016525negative regulation of angiogenesisIDA12761217 
GO:0051151negative regulation of smooth muscle cell differentiationIDA16054032 
GO:0045941positive regulation of transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIDA16272144 
GO:0005634nucleusIDA16272144 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1-HPRD11313479 
AKT1 interacts with MLLT7 (FOXO4). This interaction was modelled on a demonstrated interaction between human AKT1 and FOXO4 from an unspecified species.BIND15688030 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1MLLT7 (FOXO4) interacts with the CCND1 (Cyclin D1) promoter. This interaction was modelled on a demonstrated interaction between MLLT7 and CCND1 both from unspecified species.BIND15688030 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)FoxO4 binds the distal region of the p21Cip1 promoter. This interaction was modelled on a demonstrated interaction between FoxO4 from an unspecified species and p21Cip1 promoter from an unspecified species.BIND15084259 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID10973497 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDabeta-catenin interacts with FOXO4. This interaction was modelled on a demonstrated interaction between human FOXO4 and beta-catenin from an unspecified species.BIND15905404 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID11435445 
FOXG1BF1 | BF2 | FHKL3 | FKH2 | FKHL1 | FKHL2 | FKHL3 | FKHL4 | FOXG1A | FOXG1B | FOXG1C | HBF-1 | HBF-2 | HBF-3 | HBF-G2 | HBF2 | HFK1 | HFK2 | HFK3 | KHL2 | QINforkhead box G1FoxO4 interacts with FoxG1. This interaction was modelled on a demonstrated interaction between human FoxO4 and mouse FoxG1.BIND15084259 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3FoxO4 interacts with Smad3. This interaction was modelled on a demonstrated interaction between FoxO4 from human and Smad3 from an unspecified species.BIND15084259 
-HPRD,BioGRID15084259 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD,BioGRID15084259 
FoxO4 interacts with Smad4.BIND15084259 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)-HPRD,BioGRID11313479 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128222228m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-142-3p6856921A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-150358364m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-21413221328m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-233253321A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-296196251Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-3233253311Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3284864931A,m8hsa-miR-328brainCUGGCCCUCUCUGCCCUUCCGU
miR-339114511511Ahsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-3703633691Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-3741451511Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-499383389m8hsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
miR-5051341411A,m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-96226232m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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