Gene Page: MUC1

Summary
GeneID  4582
Symbol  MUC1
Synonyms  CD227|EMA|H23AG|MAM6|PEM|PEMT|PUM
Description  mucin 1, cell surface associated
See related  HGNC:7508|MIM:158340|Ensembl:ENSG00000185499|HPRD:01152|
Locus tag  RP11-263K19.2
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ADARB20.660.44
EPN30.620.37
CIT0.620.42
HCN20.620.46
TANC10.620.43
CLMN0.600.48
SGPP20.600.43
CHRNA20.600.27
NEFH0.600.41
HRH30.590.39
Top 10 negatively co-expressed genes
AADAT-0.34-0.35
STRADB-0.32-0.36
EMID1-0.32-0.33
PLEKHO1-0.31-0.32
ZNF599-0.31-0.28
NR2C2AP-0.31-0.35
ZNF19-0.31-0.29
CD24-0.30-0.27
C19orf57-0.30-0.25
DPYSL3-0.30-0.20
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1697589 
GO:0016324apical plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliAffinity Capture-WesternBioGRID15020226 
BAXBCL2L4BCL2-associated X proteinMUC1 C-ter interacts with the Bax promoter.BIND15710329 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)MUC1 C-ter interacts with the p21 promoter.BIND15710329 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-Western
Reconstituted Complex
BioGRID9139698 |9819408 
|11152665 |11483589 
|11877440 |12618757 
|12750561 
MUC1 interacts with beta-catenin.BIND11483589 
-HPRD9139698 |11152665 
|11483589 |11877440 
CTNND1CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120catenin (cadherin-associated protein), delta 1-HPRD,BioGRID11181067 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID11278868 |11483589 
MUC1 interacts with and is tyrosine-phosphorylated by EGFR.BIND11483589 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID11278868 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)-HPRD,BioGRID11278868 
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)-HPRD,BioGRID11278868 
GALNT1GALNAC-T1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)-HPRD12199709 |12364335 
GALNT10DKFZp586H0623 | FLJ00205 | FLJ11715 | GalNAcT10 | pp-GalNAc-T10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)-HPRD12417297 
GALNT12FLJ21212 | GalNAc-T12UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)Biochemical ActivityBioGRID12135769 
GALNT2GalNAc-T2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)-HPRD9295285 |12754287 
GALNT4GALNAC-T4 | GalNAcT4UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)Biochemical ActivityBioGRID12754287 
GALNTL2DKFZp686H1113 | GALNT13 | GALNT15 | GALNT7 | PIH5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2-HPRD15147861 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID7664271 
GSK3B-glycogen synthase kinase 3 beta-HPRD,BioGRID9819408 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobin-HPRD9139698 
Affinity Capture-Western
Co-localization
BioGRID12939402 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homologAffinity Capture-Western
Reconstituted Complex
BioGRID12750561 
OSGEPFLJ20411 | GCPL1 | KAE1 | OSGEP1 | PRSMG1O-sialoglycoprotein endopeptidase-HPRD10859271 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, delta-HPRD,BioGRID11877440 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD,BioGRID7664271 |11278868 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)MUC1 interacts with c-Src.BIND11483589 
-HPRD,BioGRID11152665 |11483589 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53MUC1 C-ter interacts with p53.BIND15710329 
 


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