Gene Page: MUSK

Summary ?
GeneID4593
SymbolMUSK
SynonymsCMS9|FADS
Descriptionmuscle, skeletal, receptor tyrosine kinase
ReferenceMIM:601296|HGNC:HGNC:7525|Ensembl:ENSG00000030304|HPRD:03190|Vega:OTTHUMG00000020485
Gene typeprotein-coding
Map location9q31.3-q32
Pascal p-value0.774

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityTASneurite (GO term level: 8)7546737 
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008582regulation of synaptic growth at neuromuscular junctionIEASynap (GO term level: 12)-
GO:0007528neuromuscular junction developmentIEASynap (GO term level: 10)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS7546737 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007517muscle developmentTAS7546737 
GO:0007275multicellular organismal developmentTAS7546737 
GO:0043113receptor clusteringIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0031594neuromuscular junctionIEAneuron, axon, Synap, Neurotransmitter (GO term level: 3)-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS7546737 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA AGR PATHWAY 3631All SZGR 2.0 genes in this pathway
BIOCARTA ACH PATHWAY 1613All SZGR 2.0 genes in this pathway
WIKMAN ASBESTOS LUNG CANCER DN 2813All SZGR 2.0 genes in this pathway
DACOSTA LOW DOSE UV RESPONSE VIA ERCC3 XPCS UP 1810All SZGR 2.0 genes in this pathway
PETRETTO BLOOD PRESSURE UP 128All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203130All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 9753All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 13087All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway