Gene Page: MX1

Summary ?
GeneID4599
SymbolMX1
SynonymsIFI-78K|IFI78|MX|MxA
DescriptionMX dynamin like GTPase 1
ReferenceMIM:147150|HGNC:HGNC:7532|Ensembl:ENSG00000157601|HPRD:00919|Vega:OTTHUMG00000086755
Gene typeprotein-coding
Map location21q22.3
Pascal p-value0.066
Sherlock p-value0.941
Fetal beta-1.894
eGeneHypothalamus
Nucleus accumbens basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2815435chr169725657MX145990.15trans
rs17092900chr173003409MX145990trans
rs16857588chr211675145MX145990trans
rs10495652chr217139288MX145990.09trans
rs6531271chr217139932MX145990.09trans
rs12620194chr217148003MX145990.09trans
rs17018721chr280385148MX145990.15trans
rs17043176chr2114025371MX145990.03trans
rs10186260chr2129538777MX145990.13trans
rs3108986chr2130360681MX145990.01trans
rs1859063chr2130363730MX145990.01trans
rs11897086chr2184596267MX145990.13trans
rs10187085chr2184614775MX145990.03trans
rs9989867chr2184628012MX145990.03trans
rs7637875chr340594263MX145990.08trans
rs890527chr3140774852MX145990.18trans
rs7612673chr3154499328MX145990.03trans
rs10461085chr430717743MX145990.16trans
rs17193303chr4181596595MX145990.16trans
rs1678893chr531763244MX145999.22E-5trans
rs10516136chr5176381368MX145990.11trans
rs13176869chr5179203478MX145990trans
rs9396602chr615766500MX145990.06trans
rs12524136chr684935440MX145990.01trans
rs9397692chr6154487314MX145991.782E-4trans
rs10485060chr6154516100MX145993.19E-4trans
rs9384190chr6154524473MX145994.312E-4trans
rs17292544chr6154544809MX145993.737E-4trans
rs4591922chr721612318MX145990.11trans
rs17171716chr740505332MX145990.05trans
rs11974883chr778068523MX145990.19trans
rs1358128chr85268072MX145990.05trans
rs9298078chr864906618MX145990.04trans
rs10283729chr92981636MX145990.08trans
rs12253931chr1063343347MX145990.19trans
rs10509151chr1063358651MX145990.02trans
rs12781009chr1063437985MX145990.12trans
rs16916549chr1063495204MX145990trans
rs11038039chr1144530644MX145990.03trans
rs11038047chr1144543848MX145990.01trans
rs17061055chr1340835399MX145993.153E-5trans
rs17066364chr1345515988MX145991.407E-4trans
rs3783149chr1345582764MX145990.01trans
rs7332969chr1345612902MX145991.407E-4trans
rs7982499chr1348397317MX145990.14trans
rs749951chr1496376252MX145990.02trans
rs16955413chr1529677652MX145992.949E-4trans
rs16955238chr1681415690MX145990trans
rs16955255chr1681420130MX145990.01trans
rs16955259chr1681420188MX145990trans
rs8105452chr1911854016MX145990.03trans
rs8104298chr1911867512MX145990trans
rs16979927chr2055019249MX145991.824E-4trans
rs2832206chr2130504653MX145990.05trans
rs17331284chrX6962964MX145990.16trans
rs17347454chrX23347700MX145991.764E-5trans
rs689365chrX97074769MX145990.01trans
rs108561330MX145990.01trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ACTC10.750.63
ALK0.750.76
PROX10.740.69
ZIC20.740.30
KRT18P190.740.05
ZIC10.730.47
PGAM20.720.43
FZD100.710.34
LAMB30.710.73
ADAMTS160.710.42
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GPR22-0.28-0.25
KLHL1-0.26-0.10
SLC26A4-0.26-0.24
EMX1-0.26-0.28
NEUROD6-0.25-0.25
IER5L-0.25-0.22
DPP4-0.25-0.23
SATB2-0.25-0.18
SLA-0.25-0.07
MPPED1-0.24-0.18

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndrome-HPRD,BioGRID11716541 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated proteinin vitro
Two-hybrid		BioGRID11716541 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group ATwo-hybridBioGRID14499622 
MX1IFI-78K | IFI78 | MX | MxAmyxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)-HPRD,BioGRID9060610 |9735310 
TRPC1HTRP-1 | MGC133334 | MGC133335 | TRP1transient receptor potential cation channel, subfamily C, member 1MxA interacts with TRPC1. This interaction was modeled on a demonstrated interaction between human MxA and TRPC1 from an unspecified species.BIND15757897 
TRPC3TRP3transient receptor potential cation channel, subfamily C, member 3MxA interacts with TRPC3. This interaction was modeled on a demonstrated interaction between human MxA and TRPC3 from unspecified species.BIND15757897 
TRPC4HTRP4 | MGC119570 | MGC119571 | MGC119572 | MGC119573 | TRP4transient receptor potential cation channel, subfamily C, member 4MxA interacts with TRPC4. This interaction was modeled on a demonstrated interaction between human MxA and TRPC4 from an unspecified species.BIND15757897 
TRPC5TRP5transient receptor potential cation channel, subfamily C, member 5MxA interacts with TRPC5. This interaction was modeled on a demonstrated interaction between human MxA and TRPC5 from unspecified species.BIND15757897 
TRPC6FLJ11098 | FLJ14863 | FSGS2 | TRP6transient receptor potential cation channel, subfamily C, member 6MxA interacts with TRPC6.BIND15757897 
TRPC7TRP7transient receptor potential cation channel, subfamily C, member 7MxA interacts with TRPC7. This interaction was modeled on a demonstrated interaction between human MxA and TRPC7 from unspecified species.BIND15757897 
TUBB2ATUBB | TUBB2 | dJ40E16.7tubulin, beta 2A-HPRD1629950 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 6645All SZGR 2.0 genes in this pathway
REACTOME INTERFERON ALPHA BETA SIGNALING 6450All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159116All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS DN 2518All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175108All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204140All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205145All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 1 4423All SZGR 2.0 genes in this pathway
BOWIE RESPONSE TO EXTRACELLULAR MATRIX 1711All SZGR 2.0 genes in this pathway
BOWIE RESPONSE TO TAMOXIFEN 1810All SZGR 2.0 genes in this pathway
XU HGF TARGETS INDUCED BY AKT1 6HR 198All SZGR 2.0 genes in this pathway
XU AKT1 TARGETS 6HR 2718All SZGR 2.0 genes in this pathway
EINAV INTERFERON SIGNATURE IN CANCER 2716All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS DN 5034All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP 7347All SZGR 2.0 genes in this pathway
KANG GIST WITH PDGFRA UP 5027All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 8860All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP 7448All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP 5036All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 10267All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 14498All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 7850All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 8356All SZGR 2.0 genes in this pathway
ROETH TERT TARGETS UP 1411All SZGR 2.0 genes in this pathway
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS 3121All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION 2 5334All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE UP 117All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 DN 6545All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 6844All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS UP 3824All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 12089All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN UP 3021All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP 9365All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 7148All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 4739All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
MOSERLE IFNA RESPONSE 3119All SZGR 2.0 genes in this pathway
HONMA DOCETAXEL RESISTANCE 3423All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS 8056All SZGR 2.0 genes in this pathway
ZHANG INTERFERON RESPONSE 2314All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181106All SZGR 2.0 genes in this pathway
UROSEVIC RESPONSE TO IMIQUIMOD 2314All SZGR 2.0 genes in this pathway
GUTIERREZ MULTIPLE MYELOMA UP 3524All SZGR 2.0 genes in this pathway
CHIARETTI T ALL REFRACTORY TO THERAPY 3018All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 5024All SZGR 2.0 genes in this pathway
CERIBELLI PROMOTERS INACTIVE AND BOUND BY NFY 4420All SZGR 2.0 genes in this pathway
CERIBELLI GENES INACTIVE AND BOUND BY NFY 4527All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP 12170All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266142All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 7848All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 9554All SZGR 2.0 genes in this pathway