Gene Page: MYH6

Summary
GeneID  4624
Symbol  MYH6
Synonyms  ASD3|MYHC|MYHCA|alpha-MHC
Description  myosin, heavy chain 6, cardiac muscle, alpha
See related  HGNC:7576|MIM:160710|Ensembl:ENSG00000197616|HPRD:01171|
Locus tag  -
Gene type  protein-coding
Map location  14q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF2760.910.90
STARD90.880.92
GIGYF10.880.89
USP360.860.87
ANKS60.860.86
LRCH40.850.86
TRPV10.850.84
KIAA04670.850.86
PLEKHM1P0.840.82
H6PD0.830.87
Top 10 negatively co-expressed genes
GMFG-0.52-0.63
RERGL-0.50-0.62
COX5B-0.50-0.56
C1orf54-0.49-0.58
SEPW1-0.49-0.66
CARD16-0.49-0.57
NDUFB9-0.49-0.60
LY96-0.49-0.64
ACOT13-0.49-0.50
AF347015.31-0.49-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000146microfilament motor activityISS-
GO:0000166nucleotide bindingIEA-
GO:0003779actin bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0005524ATP bindingIC16088376 
GO:0008307structural constituent of muscleIDA15621050 |16088376 
GO:0016887ATPase activityIDA15621050 
GO:0030898actin-dependent ATPase activityIMP16088376 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001701in utero embryonic developmentISS-
GO:0002026regulation of the force of heart contractionISS-
GO:0002027regulation of heart rateIDA15621050 
GO:0055010ventricular cardiac muscle morphogenesisIMP11815426 |15998695 
GO:0055009atrial cardiac muscle morphogenesisIMP15735645 
GO:0008217regulation of blood pressureISS-
GO:0007512adult heart developmentIMP15735645 |15998695 
GO:0007522visceral muscle developmentISS-
GO:0006941striated muscle contractionIEA-
GO:0048739cardiac muscle fiber developmentISS-
GO:0043462regulation of ATPase activityISS-
GO:0030049muscle filament slidingIMP16088376 
GO:0045214sarcomere organizationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005863striated muscle thick filamentIEA-
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005925focal adhesionIDA18029348 
GO:0016459myosin complexTAS12933792 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MYL7MYL2A | MYLC2Amyosin, light chain 7, regulatoryMYH6 interacts with MYL7 (RLC). This interaction was modelled on a demonstrated interaction between mouse MYH6 and human MYL7.BIND15735645 
 


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