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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: MYLK

Summary

GeneID

4638

Symbol

MYLK

Synonyms

Description

myosin light chain kinase

Locus tag

Gene type

protein-coding

Map location

3q21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0166

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

RBPSUH

0.89

0.76

PELI2

0.88

0.76

SOX5

0.88

0.83

NFIB

0.88

0.82

ZFPM2

0.86

0.83

PPAT

0.86

0.82

PLCL2

0.85

NPR3

0.85

0.73

USP3

0.85

0.66

XPR1

0.85

0.79

Top 10 negatively co-expressed genes

FXYD1

-0.51

-0.73

IFI27

-0.50

-0.70

MT-CO2

-0.49

-0.72

AF347015.31

-0.49

-0.70

AF347015.27

-0.49

-0.69

TNFSF12

-0.49

-0.46

AF347015.33

-0.48

-0.68

LGI4

-0.48

-0.39

SERPINB6

-0.48

-0.52

SLC9A3R2

-0.48

-0.38

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0000287

magnesium ion binding

IEA

GO:0005509

calcium ion binding

IEA

GO:0005516

calmodulin binding

IEA

GO:0005524

ATP binding

IEA

GO:0004687

myosin light chain kinase activity

TAS

8575746

GO:0016740

transferase activity

IEA

GO:0016301

kinase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

TAS

8575746

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTC1	ACTC \| CMD1R \| CMH11	actin, alpha, cardiac muscle 1	-	HPRD	12110694
CALM1	CALML2 \| CAMI \| DD132 \| PHKD	calmodulin 1 (phosphorylase kinase, delta)	-	HPRD,BioGRID	7947686
CTTN	EMS1 \| FLJ34459	cortactin	-	HPRD,BioGRID	12408982
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	-	HPRD	10402467
MLC1	KIAA0027 \| LVM \| MLC \| VL	megalencephalic leukoencephalopathy with subcortical cysts 1	Biochemical Activity	BioGRID	10092231
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD,BioGRID	10092231
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	protein kinase C, alpha	-	HPRD	3160694
PRKG2	PRKGR2 \| cGKII	protein kinase, cGMP-dependent, type II	-	HPRD,BioGRID	6547441
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	10362724

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	1267	1274	1A,m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-129-5p	60	66	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	60	66	1A	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-15/16/195/424/497	1455	1462	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-24	485	491	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-362	1779	1785	1A	hsa-miR-362	AAUCCUUGGAACCUAGGUGUGAGU
miR-365	177	184	1A,m8	hsa-miR-365	UAAUGCCCCUAAAAAUCCUUAU
miR-409-3p	1266	1272	m8	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-495	1800	1806	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-93.hd/291-3p/294/295/302/372/373/520	1171	1177	1A	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.