Gene Page: ACLY

Summary
GeneID  47
Symbol  ACLY
Synonyms  ACL|ATPCL|CLATP
Description  ATP citrate lyase
See related  HGNC:115|MIM:108728|Ensembl:ENSG00000131473|HPRD:00155|
Locus tag  -
Gene type  protein-coding
Map location  17q12-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CLPTM10.880.86
CTSD0.870.88
SLC6A80.850.85
TFE30.850.85
PSAP0.850.85
PEBP10.840.81
PDK20.840.83
PDXK0.830.81
ALDOA0.830.84
WBP20.820.79
Top 10 negatively co-expressed genes
FAM159B-0.54-0.71
RP9P-0.50-0.57
AC005921.3-0.50-0.59
KCNMB3-0.49-0.43
EIF5B-0.48-0.53
AC120053.1-0.46-0.45
NOX1-0.46-0.41
AC087071.1-0.46-0.36
SNHG12-0.46-0.51
AC135724.1-0.45-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0003824catalytic activityIEA-
GO:0003878ATP citrate synthase activityIEA-
GO:0003878ATP citrate synthase activityTAS1371749 
GO:0005488bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0004775succinate-CoA ligase (ADP-forming) activityIEA-
GO:0016740transferase activityIEA-
GO:0008815citrate (pro-3S)-lyase activityEXP1371749 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006200ATP catabolic processTAS1371749 
GO:0006101citrate metabolic processTAS1371749 
GO:0008610lipid biosynthetic processIEA-
GO:0008152metabolic processIEA-
GO:0015936coenzyme A metabolic processTAS1371749 
GO:0044262cellular carbohydrate metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP1371749 
GO:0005737cytoplasmIEA-
GO:0009346citrate lyase complexTAS1371749 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GSK3B-glycogen synthase kinase 3 betaAffinity Capture-MSBioGRID17353931 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilonAffinity Capture-MSBioGRID17353931 
NME2MGC111212 | NDPK-B | NDPKB | NM23-H2 | NM23B | pufnon-metastatic cells 2, protein (NM23B) expressed inAffinity Capture-MSBioGRID17353931 
PRKAB1AMPK | HAMPKb | MGC17785protein kinase, AMP-activated, beta 1 non-catalytic subunitAffinity Capture-MSBioGRID17353931 
TFE3RCCP2 | TFEA | bHLHe33transcription factor binding to IGHM enhancer 3Affinity Capture-MSBioGRID17353931 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-14939m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-204/2113723781Ahsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-214251257m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-276977031Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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