Gene Page: ATP2A1

Summary
GeneID  487
Symbol  ATP2A1
Synonyms  ATP2A|SERCA1
Description  ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
See related  HGNC:811|MIM:108730|Ensembl:ENSG00000196296|HPRD:00157|
Locus tag  -
Gene type  protein-coding
Map location  16p12.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GPR1580.930.77
HOOK10.900.92
RGS7BP0.900.89
NCOA70.890.92
SLMAP0.890.88
CHM0.890.90
SYNJ10.890.93
PPP3CA0.890.88
FAM179B0.890.87
ATP2A20.880.91
Top 10 negatively co-expressed genes
RAB34-0.46-0.57
EFEMP2-0.46-0.50
RAB13-0.46-0.59
NME4-0.44-0.54
BCL7C-0.44-0.49
DBI-0.43-0.52
RFXANK-0.42-0.49
AC006276.2-0.42-0.41
IMPA2-0.41-0.53
IRF7-0.41-0.54
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005509calcium ion bindingIMP9405806 
GO:0005515protein bindingIPI9295312 
GO:0005524ATP bindingIEA-
GO:0005388calcium-transporting ATPase activityIDA8729696 
GO:0005388calcium-transporting ATPase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008152metabolic processIEA-
GO:0006816calcium ion transportIEA-
GO:0006816calcium ion transportIMP9405806 
GO:0006812cation transportIEA-
GO:0006810transportIEA-
GO:0006942regulation of striated muscle contractionTAS8841193 
GO:0015992proton transportIEA-
GO:0031448positive regulation of fast-twitch skeletal muscle fiber contractionIDA12479237 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS9405806 
GO:0033017sarcoplasmic reticulum membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
IRS1HIRS-1insulin receptor substrate 1-HPRD9295312 
IRS2-insulin receptor substrate 2-HPRD9295312 
PLNCMD1P | PLBphospholamban-HPRD,BioGRID10551848 |11526231 
SLNMGC12301 | MGC125854 | MGC125855sarcolipin-HPRD9575189 |12692302|12692302 
-HPRD9575189 |12692302 
Affinity Capture-WesternBioGRID12032137 |12692302 
TNFRSF1BCD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFRtumor necrosis factor receptor superfamily, member 1B-HPRD14743216 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-4912026m8hsa-miR-491brainAGUGGGGAACCCUUCCAUGAGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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