Gene Page: ORC2L

Summary
GeneID  4999
Symbol  ORC2L
Synonyms  ORC2
Description  origin recognition complex, subunit 2-like (yeast)
See related  HGNC:8488|MIM:601182|Ensembl:ENSG00000115942|HPRD:03112|
Locus tag  -
Gene type  protein-coding
Map location  2q33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0064 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EXTL10.690.62
LTK0.680.61
VIPR10.670.61
TPST20.660.62
MPL0.660.62
STAT60.660.64
HLA-DQB10.650.60
ITPKA0.650.62
CA110.650.64
KCNK10.650.63
Top 10 negatively co-expressed genes
RBMX2-0.45-0.56
THOC2-0.44-0.50
FAM36A-0.44-0.45
ZNF326-0.44-0.50
TUBB2B-0.43-0.52
KIAA1949-0.43-0.43
PKN1-0.43-0.47
EIF5B-0.43-0.50
UPF3B-0.43-0.50
UPF3A-0.43-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003688DNA replication origin bindingTAS8808289 
GO:0005515protein bindingIPI11095689 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS8808289 
GO:0006270DNA replication initiationTAS8808289 
GO:0006260DNA replicationEXP12791985 
GO:0006260DNA replicationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000785chromatinIEA-
GO:0000939inner kinetochore of condensed chromosomeIEA-
GO:0005634nucleusTAS8808289 
GO:0005654nucleoplasmEXP10436018 |11095689 |11125146 
|11931757 |12045100 
|15226314 |15684404 
|15707391 
GO:0005664nuclear origin of replication recognition complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetAffinity Capture-WesternBioGRID17525332 
CCNA2CCN1 | CCNAcyclin A2Affinity Capture-WesternBioGRID11931757 
CDC45LCDC45 | CDC45L2 | PORC-PI-1CDC45 cell division cycle 45-like (S. cerevisiae)Two-hybridBioGRID12614612 
CDC6CDC18L | HsCDC18 | HsCDC6cell division cycle 6 homolog (S. cerevisiae)-HPRD,BioGRID12614612 
CDK2p33(CDK2)cyclin-dependent kinase 2-HPRD15232106 
Biochemical ActivityBioGRID11931757 
DBF4ASK | CHIF | DBF4A | ZDBF1DBF4 homolog (S. cerevisiae)-HPRD,BioGRID12614612 
HBBCD113t-Chemoglobin, betaOrc2 interacts with beta-globin origin.BIND15910003 
LMNB2LAMB2 | LMN2 | MGC2721lamin B2Orc2 interacts with Lamin B2 origin.BIND15910003 
MCM10CNA43 | DNA43 | MGC126776 | PRO2249minichromosome maintenance complex component 10-HPRD,BioGRID11095689 
MCM2BM28 | CCNL1 | CDCL1 | D3S3194 | KIAA0030 | MGC10606 | MITOTIN | cdc19minichromosome maintenance complex component 2-HPRD,BioGRID12614612 
MCM4CDC21 | CDC54 | MGC33310 | P1-CDC21 | hCdc21minichromosome maintenance complex component 4Two-hybridBioGRID12614612 
MCM5CDC46 | MGC5315 | P1-CDC46minichromosome maintenance complex component 5Two-hybridBioGRID12614612 
MCM6MCG40308 | Mis5 | P105MCMminichromosome maintenance complex component 6Two-hybridBioGRID12614612 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7-HPRD,BioGRID12614612 
MCM8C20orf154 | MGC119522 | MGC119523 | MGC12866 | MGC4816 | REC | dJ967N21.5minichromosome maintenance complex component 8MCM8 interacts with ORC2.BIND15684404 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Ocr2 interacts with C-Myc origin.BIND15910003 
ORC1LHSORC1 | ORC1 | PARC1origin recognition complex, subunit 1-like (yeast)-HPRD,BioGRID11323433 |11779870 
ORC2LORC2origin recognition complex, subunit 2-like (yeast)Two-hybridBioGRID12614612 
ORC3LLAT | LATHEO | ORC3origin recognition complex, subunit 3-like (yeast)-HPRD,BioGRID10402192 |11323433 
|11395502 
ORC4LORC4 | ORC4Porigin recognition complex, subunit 4-like (yeast)Affinity Capture-Western
Co-purification
Reconstituted Complex
Two-hybrid		BioGRID9353276 |11323433 
|11395502 |12614612 
ORC5LORC5 | ORC5P | ORC5Torigin recognition complex, subunit 5-like (yeast)Affinity Capture-Western
Co-purification
Reconstituted Complex
Two-hybrid		BioGRID9765232 |11323433 
|11395502 |12614612 
ORC6LORC6origin recognition complex, subunit 6 like (yeast)-HPRD,BioGRID11323433 
RPA1HSSB | REPA1 | RF-A | RP-A | RPA70replication protein A1, 70kDa-HPRD,BioGRID12614612 
RPA2REPA2 | RPA32replication protein A2, 32kDa-HPRD,BioGRID12614612 
XRCC5FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIVX-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)-HPRD,BioGRID12393188 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-122346352m8hsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-124/506215221m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-125/3512682751A,m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-153185191m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-30-5p74811A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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