Gene Page: ORC4L

Summary
GeneID  5000
Symbol  ORC4L
Synonyms  ORC4|ORC4P
Description  origin recognition complex, subunit 4-like (yeast)
See related  HGNC:8490|MIM:603056|Ensembl:ENSG00000115947|HPRD:09118|
Locus tag  -
Gene type  protein-coding
Map location  2q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.023 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PPAN-P2RY110.930.94
C19orf60.870.88
MZF10.860.88
TAOK20.860.88
SH2B10.860.87
LRRC4B0.860.88
FCHO10.850.86
SOLH0.850.88
FAM160B20.850.87
KRBA10.840.88
Top 10 negatively co-expressed genes
AF347015.21-0.64-0.68
GNG11-0.63-0.68
AF347015.31-0.62-0.59
AF347015.27-0.60-0.58
C1orf54-0.59-0.65
MT-CO2-0.59-0.57
AF347015.8-0.57-0.56
COPZ2-0.56-0.57
NOSTRIN-0.56-0.57
AC021016.1-0.55-0.59
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIDA9353276 
GO:0003677DNA bindingIEA-
GO:0003688DNA replication origin bindingIMP9353276 
GO:0005515protein bindingIPI15232106 
GO:0005524ATP bindingIEA-
GO:0017111nucleoside-triphosphatase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006270DNA replication initiationIMP9353276 
GO:0006260DNA replicationEXP12791985 
GO:0006260DNA replicationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA9353276 
GO:0005654nucleoplasmEXP10436018 |11095689 |11125146 
|11931757 |12045100 
|15226314 |15684404 
|15707391 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DBF4ASK | CHIF | DBF4A | ZDBF1DBF4 homolog (S. cerevisiae)Affinity Capture-WesternBioGRID12614612 
MCM10CNA43 | DNA43 | MGC126776 | PRO2249minichromosome maintenance complex component 10-HPRD15232106 
MCM2BM28 | CCNL1 | CDCL1 | D3S3194 | KIAA0030 | MGC10606 | MITOTIN | cdc19minichromosome maintenance complex component 2Two-hybridBioGRID12614612 
MCM3HCC5 | MGC1157 | P1-MCM3 | P1.h | RLFBminichromosome maintenance complex component 3Two-hybridBioGRID12614612 
MCM4CDC21 | CDC54 | MGC33310 | P1-CDC21 | hCdc21minichromosome maintenance complex component 4Two-hybridBioGRID12614612 
MCM6MCG40308 | Mis5 | P105MCMminichromosome maintenance complex component 6Two-hybridBioGRID12614612 
ORC1LHSORC1 | ORC1 | PARC1origin recognition complex, subunit 1-like (yeast)-HPRD11323433 
Two-hybridBioGRID12614612 
ORC2LORC2origin recognition complex, subunit 2-like (yeast)Affinity Capture-Western
Co-purification
Reconstituted Complex
Two-hybrid		BioGRID9353276 |11323433 
|11395502 |12614612 
ORC3LLAT | LATHEO | ORC3origin recognition complex, subunit 3-like (yeast)-HPRD11323433 |11395502 
|15232106 
-HPRD,BioGRID11323433 
ORC5LORC5 | ORC5P | ORC5Torigin recognition complex, subunit 5-like (yeast)Affinity Capture-Western
Co-purification
Two-hybrid		BioGRID9765232 |11395502 
|12614612 
-HPRD11323433 
ORC6LORC6origin recognition complex, subunit 6 like (yeast)Affinity Capture-Western
Two-hybrid		BioGRID12614612 
RPA2REPA2 | RPA32replication protein A2, 32kDaTwo-hybridBioGRID12614612 
 


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