Gene Page: OSM

Summary
GeneID  5008
Symbol  OSM
Synonyms  MGC20461
Description  oncostatin M
See related  HGNC:8506|MIM:165095|Ensembl:ENSG00000099985|HPRD:01300|
Locus tag  -
Gene type  protein-coding
Map location  22q12.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005147oncostatin-M receptor bindingTAS9920829 
GO:0005125cytokine activityTAS2779549 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthIEA-
GO:0008285negative regulation of cell proliferationTAS1717982 
GO:0009408response to heatIEA-
GO:0007422peripheral nervous system developmentIEA-
GO:0006955immune responseIEA-
GO:0006915apoptosisIEA-
GO:0007275multicellular organismal developmentTAS1717982 
GO:0033138positive regulation of peptidyl-serine phosphorylationIDA7508917 
GO:0042508tyrosine phosphorylation of Stat1 proteinIEA-
GO:0042506tyrosine phosphorylation of Stat5 proteinIEA-
GO:0042503tyrosine phosphorylation of Stat3 proteinIEA-
GO:0048266behavioral response to painIEA-
GO:0043410positive regulation of MAPKKK cascadeIDA7508917 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA7508917 
GO:0046888negative regulation of hormone secretionIDA7867561 
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA7508917 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceTAS2779549 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
COL4A1arrestencollagen, type IV, alpha 1-HPRD,BioGRID11711546 
COL4A2DKFZp686I14213 | FLJ22259collagen, type IV, alpha 2-HPRD,BioGRID11711546 
COL4A3-collagen, type IV, alpha 3 (Goodpasture antigen)-HPRD,BioGRID11711546 
COL4A4CA44collagen, type IV, alpha 4-HPRD,BioGRID11711546 
COL4A5ASLN | ATS | CA54 | MGC167109 | MGC42377collagen, type IV, alpha 5-HPRD,BioGRID11711546 
COL4A6MGC88184collagen, type IV, alpha 6-HPRD,BioGRID11711546 
IL6STCD130 | CDw130 | GP130 | GP130-RAPS | IL6R-betainterleukin 6 signal transducer (gp130, oncostatin M receptor)-HPRD8999038 
LIFRCD118 | FLJ98106 | FLJ99923 | LIF-R | SJS2 | STWS | SWSleukemia inhibitory factor receptor alpha-HPRD,BioGRID1536831 |1542794 
OSMRMGC150626 | MGC150627 | MGC75127 | OSMRBoncostatin M receptor-HPRD8999038 |10997905 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
PID_GMCSF_PATHWAY 3731All SZGR genes in this pathway
PID_IL3_PATHWAY 2719All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_DN 3119All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC 10874All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3 13785All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-3637407461Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-543100610121Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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