Gene Page: PAFAH1B2

Summary
GeneID  5049
Symbol  PAFAH1B2
Synonyms  -
Description  platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa
See related  HGNC:8575|MIM:602508|Ensembl:ENSG00000168092|HPRD:03940|
Locus tag  -
Gene type  protein-coding
Map location  11q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0044 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC6A70.720.70
AC013418.10.690.68
EPB41L4B0.670.75
AC112491.30.670.67
SLC12A50.670.75
ZMAT40.660.75
FSTL40.660.73
KCNS20.650.71
BMPER0.650.72
ABCG40.650.69
Top 10 negatively co-expressed genes
PDE9A-0.34-0.47
GTF3C6-0.34-0.42
EXOSC8-0.33-0.42
SH2D2A-0.33-0.50
RBMX2-0.32-0.48
RPL23A-0.32-0.48
GPR125-0.32-0.41
C6orf48-0.32-0.42
NME4-0.32-0.52
RPS19P3-0.31-0.53
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activityIEA-
GO:0016788hydrolase activity, acting on ester bondsIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016042lipid catabolic processIEA-
GO:0007283spermatogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmTAS16130169 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACIN1ACINUS | ACN | DKFZp667N107 | KIAA0670 | fSAP152apoptotic chromatin condensation inducer 1Two-hybridBioGRID16169070 
CCT3CCT-gamma | CCTG | PIG48 | TCP-1-gamma | TRIC5chaperonin containing TCP1, subunit 3 (gamma)Two-hybridBioGRID16169070 
PAFAH1B1LIS1 | LIS2 | MDCR | MDS | PAFAHplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa-HPRD,BioGRID10727864 
PAFAH1B3-platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDaTwo-hybridBioGRID16189514 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkinTwo-hybridBioGRID16169070 
PINX1FLJ20565 | LPTL | LPTS | MGC8850PIN2-interacting protein 1Two-hybridBioGRID16169070 
PPP1R12CDKFZp434D0412 | LENG3 | p84protein phosphatase 1, regulatory (inhibitor) subunit 12CTwo-hybridBioGRID16169070 
REXO1ELOABP1 | EloA-BP1 | KIAA1138 | REX1 | TCEB3BP1REX1, RNA exonuclease 1 homolog (S. cerevisiae)Two-hybridBioGRID16169070 
RPLP0L10E | MGC111226 | MGC88175 | P0 | PRLP0 | RPP0ribosomal protein, large, P0Two-hybridBioGRID16169070 
TIMM50MGC102733 | TIM50 | TIM50Ltranslocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)Two-hybridBioGRID16169070 
ZFP36L1BRF1 | Berg36 | ERF-1 | ERF1 | RNF162B | TIS11B | cMG1zinc finger protein 36, C3H type-like 1Two-hybridBioGRID16169070 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a12191A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-3p58641Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-17-5p/20/93.mr/106/519.d8591m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.