Gene Page: NOX3
Summary ?
| GeneID | 50508 |
| Symbol | NOX3 |
| Synonyms | GP91-3|MOX-2 |
| Description | NADPH oxidase 3 |
| Reference | MIM:607105|HGNC:HGNC:7890|Ensembl:ENSG00000074771|HPRD:06165|Vega:OTTHUMG00000015883 |
| Gene type | protein-coding |
| Map location | 6q25.3 |
| Pascal p-value | 0.297 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs13218521 | chr6 | 155733726 | NOX3 | 50508 | 0.11 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005506 | iron ion binding | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0016175 | superoxide-generating NADPH oxidase activity | IEA | - | |
| GO:0009055 | electron carrier activity | IEA | - | |
| GO:0016491 | oxidoreductase activity | IEA | - | |
| GO:0050660 | FAD binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0001659 | temperature homeostasis | IEA | - | |
| GO:0009590 | detection of gravity | IEA | - | |
| GO:0048840 | otolith development | IEA | - | |
| GO:0042554 | superoxide release | IEA | - | |
| GO:0055114 | oxidation reduction | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0043020 | NADPH oxidase complex | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION | 118 | 78 | All SZGR 2.0 genes in this pathway |
| WILCOX RESPONSE TO PROGESTERONE DN | 66 | 44 | All SZGR 2.0 genes in this pathway |
| XU GH1 EXOGENOUS TARGETS DN | 120 | 69 | All SZGR 2.0 genes in this pathway |
| ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |