Gene Page: PARN

Summary
GeneID  5073
Symbol  PARN
Synonyms  DAN
Description  poly(A)-specific ribonuclease (deadenylation nuclease)
See related  HGNC:8609|MIM:604212|HPRD:07250|
Locus tag  -
Gene type  protein-coding
Map location  16p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ADAMTS10.690.65
ICAM10.680.58
APOLD10.660.46
LRRC320.650.49
EFEMP10.650.60
FOXF10.650.55
SDC40.650.59
AC087645.10.650.59
TPCN10.640.51
ACOT110.630.56
Top 10 negatively co-expressed genes
ASNSD1-0.40-0.53
ATXN10-0.40-0.50
UBE2E3-0.39-0.51
TUBB2A-0.39-0.54
PODXL2-0.39-0.54
MLLT11-0.39-0.52
FXYD6-0.39-0.50
PURG-0.39-0.51
SMAP1-0.39-0.53
SPATS2-0.39-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0003723RNA bindingIEA-
GO:0003730mRNA 3'-UTR bindingTAS9736620 
GO:0005515protein bindingIPI15231747 
GO:0004535poly(A)-specific ribonuclease activityIEA-
GO:0004527exonuclease activityIEA-
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEA-
GO:0007292female gamete generationTAS9736620 
GO:0009451RNA modificationTAS9736620 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS9736620 
GO:0005737cytoplasmTAS9736620 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C21orf56DKFZp434N0650 | MGC99490chromosome 21 open reading frame 56Two-hybridBioGRID15231747 
KHSRPFBP2 | FUBP2 | KSRP | MGC99676KH-type splicing regulatory protein-HPRD,BioGRID15175153 
MPHOSPH6MPP | MPP-6 | MPP6M-phase phosphoprotein 6-HPRD15231747 
UPF1FLJ43809 | FLJ46894 | HUPF1 | KIAA0221 | NORF1 | RENT1 | pNORF1UPF1 regulator of nonsense transcripts homolog (yeast)Affinity Capture-WesternBioGRID14527413 
UPF2DKFZp434D222 | HUPF2 | KIAA1408 | MGC138834 | MGC138835 | RENT2 | smg-3UPF2 regulator of nonsense transcripts homolog (yeast)Affinity Capture-WesternBioGRID14527413 
UPF3AHUPF3A | RENT3A | UPF3UPF3 regulator of nonsense transcripts homolog A (yeast)Affinity Capture-WesternBioGRID14527413 
 


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