Gene Page: IKBKG

Summary
GeneID  8517
Symbol  IKBKG
Synonyms  AMCBX1|FIP-3|FIP3|Fip3p|IKK-gamma|IP|IP1|IP2|IPD2|NEMO
Description  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
See related  HGNC:5961|MIM:300248|Ensembl:ENSG00000073009|HPRD:02217|
Locus tag  -
Gene type  protein-coding
Map location  Xq28
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS9927690 
GO:0005515protein bindingIPI11113112 
GO:0008270zinc ion bindingIEA-
GO:0016301kinase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001782B cell homeostasisIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007250activation of NF-kappaB-inducing kinase activityIEA-
GO:0006917induction of apoptosisTAS9927690 
GO:0006955immune responseTAS9751060 
GO:0050852T cell receptor signaling pathwayNAS15125833 
GO:0050852T cell receptor signaling pathwayTAS16831874 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9744859 |10723127 
GO:0005622intracellularIDA11256614 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0008385IkappaB kinase complexTAS16831874 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATG16L1APG16L | ATG16L | FLJ00045 | FLJ10035 | FLJ10828 | FLJ22677 | IBD10 | WDR30ATG16 autophagy related 16-like 1 (S. cerevisiae)-HPRD,BioGRID14743216 
BCL10CARMEN | CIPER | CLAP | c-E10 | mE10B-cell CLL/lymphoma 10Bcl10 interacts with NEMO.BIND14695475 
CARD8CARDINAL | DACAR | DKFZp779L0366 | Dakar | FLJ18119 | FLJ18121 | KIAA0955 | MGC57162 | NDPP | NDPP1 | TUCANcaspase recruitment domain family, member 8-HPRD,BioGRID11551959 
CCAR1CARP-1 | CARP1 | MGC44628 | RP11-437A18.1cell division cycle and apoptosis regulator 1-HPRD14743216 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)-HPRD,BioGRID11864612 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinaseAffinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid
BioGRID10968790 |11864612 
|11877453 
-HPRD10968790 |12133833 
COPS3SGN3COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)-HPRD,BioGRID11418127 
CSE1LCAS | CSE1 | MGC117283 | MGC130036 | MGC130037 | XPO2CSE1 chromosome segregation 1-like (yeast)-HPRD14743216 
CYLDCDMT | CYLD1 | CYLDI | EAC | FLJ20180 | FLJ31664 | FLJ78684 | HSPC057 | KIAA0849 | MFT | MFT1 | SBS | TEM | USPL2cylindromatosis (turban tumor syndrome)CYLD interacts with NEMO.BIND12917691 
DBN1D0S117E | DKFZp434D064drebrin 1-HPRD14743216 
DDB1DDBA | UV-DDB1 | XAP1 | XPCE | XPE | XPE-BFdamage-specific DNA binding protein 1, 127kDa-HPRD14743216 
F7-coagulation factor VII (serum prothrombin conversion accelerator)-HPRD14743216 
FAM62AKIAA0747 | MBC2family with sequence similarity 62 (C2 domain containing), member A-HPRD14743216 
GCN1L1GCN1 | GCN1L | KIAA0219GCN1 general control of amino-acid synthesis 1-like 1 (yeast)-HPRD14743216 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD11864612 
HSP90AA2HSP90ALPHA | HSPCA | HSPCAL3heat shock protein 90kDa alpha (cytosolic), class A member 2Affinity Capture-MSBioGRID14743216 
HSPA1AFLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1Bheat shock 70kDa protein 1AReconstituted ComplexBioGRID11877453 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
IGHG3DKFZp686H11213 | FLJ39988 | FLJ40036 | FLJ40253 | FLJ40587 | FLJ40789 | FLJ40834 | IgG3 | MGC45809immunoglobulin heavy constant gamma 3 (G3m marker)-HPRD14743216 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta-HPRD,BioGRID10968790 
NEMO interacts with IKK-beta.BIND15802604 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaIKK-gamma can homo-dimerize and homo-trimerize.BIND12435599 
IPO9DKFZp761M1547 | FLJ10402 | Imp9importin 9-HPRD14743216 
IRS1HIRS-1insulin receptor substrate 1-HPRD12351658 
KIAA0368ECM29 | FLJ22036 | KIAA1962 | RP11-386D8.2KIAA0368-HPRD14743216 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD,BioGRID9927690 
MAP3K7IP3MGC45404 | NAP1 | TAB3mitogen-activated protein kinase kinase kinase 7 interacting protein 3TAB3 interacts with NEMO.BIND15327770 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7-HPRD14743216 
MRCL3MLCB | MRLC3myosin regulatory light chain MRCL3-HPRD14743216 
MYL6ESMLC | LC17-GI | LC17-NM | LC17A | LC17B | MLC1SM | MLC3NM | MLC3SMmyosin, light chain 6, alkali, smooth muscle and non-muscle-HPRD14743216 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3Affinity Capture-MS
Affinity Capture-Western
Co-fractionation
Reconstituted Complex
BioGRID11971985 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Affinity Capture-MSBioGRID14743216 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)Affinity Capture-MSBioGRID14743216 
PPM1BMGC21657 | PP2C-beta-X | PP2CB | PP2CBETA | PPC2BETAXprotein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform-HPRD,BioGRID14585847 
PPP1CBMGC3672 | PP-1B | PPP1CDprotein phosphatase 1, catalytic subunit, beta isoform-HPRD14743216 
PRKCQMGC126514 | MGC141919 | PRKCT | nPKC-thetaprotein kinase C, thetaPKC-theta interacts with NEMO.BIND15802604 
RAB11BH-YPT3 | MGC133246RAB11B, member RAS oncogene family-HPRD,BioGRID11495908 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD,BioGRID10880512 
RIPK2CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2receptor-interacting serine-threonine kinase 2-HPRD,BioGRID10880512 
RPS27L-ribosomal protein S27-like-HPRD14743216 
RPS3FLJ26283 | FLJ27450 | MGC87870ribosomal protein S3-HPRD14743216 
SFXN1FLJ12876sideroflexin 1-HPRD14743216 
TANKI-TRAF | TRAF2TRAF family member-associated NFKB activator-HPRD,BioGRID12133833 
IKK-gamma interacts with TANK.BIND12133833 
TBK1FLJ11330 | NAK | T2KTANK-binding kinase 1Affinity Capture-MSBioGRID14743216 
TNFAIP3A20 | MGC104522 | MGC138687 | MGC138688 | OTUD7C | TNFA1P2tumor necrosis factor, alpha-induced protein 3-HPRD,BioGRID10755617 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD,BioGRID10755617 
TNIP2ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289TNFAIP3 interacting protein 2-HPRD14653779 
TRAF3IP2ACT1 | C6orf2 | C6orf4 | C6orf5 | C6orf6 | CIKS | DKFZp586G0522 | MGC3581TRAF3 interacting protein 2An unspecified isoform of CIKS interacts with IKK-gamma. This interaction was modeled on a demonstrated interaction between CIKS from an unspecified species and mouse IKK-gamma.BIND12133833 
NEMO interacts with CIKS. This interaction was modeled on a demonstrated interaction between mouse NEMO and human CIKS.BIND12133833 
-HPRD,BioGRID10962024 |10962033 
TRPC4APC20orf188 | TRRP4AP | TRUSStransient receptor potential cation channel, subfamily C, member 4 associated proteinAffinity Capture-WesternBioGRID14585990 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
TUBA4BFLJ13940 | TUBA4tubulin, alpha 4b (pseudogene)-HPRD14743216 
UBBFLJ25987 | MGC8385ubiquitin BUb ubiquitinates NEMO.BIND14695475 
VARSG7A | VARS1 | VARS2valyl-tRNA synthetase-HPRD14743216 
ZFAND5ZA20D2 | ZFAND5A | ZNF216zinc finger, AN1-type domain 5-HPRD,BioGRID14754897 
ZNF216 interacts with IKK-gamma.BIND14754897 
 


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.