Gene Page

Gene Page: PCTK2

Summary

GeneID

5128

Symbol

PCTK2

Synonyms

PCTAIRE2

Description

PCTAIRE protein kinase 2

Locus tag

Gene type

protein-coding

Map location

12q23.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0125

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

IMMT

0.89

0.81

NDUFS2

0.87

0.78

ABCF2

0.86

0.82

GARS

0.86

0.80

PPP2R5D

0.86

0.78

GALNT11

0.86

0.79

PPME1

0.85

0.81

PSMD1

0.85

0.79

HARS

0.85

0.77

GRPEL1

0.85

0.75

Top 10 negatively co-expressed genes

AF347015.21

-0.82

-0.68

MT-CO2

-0.76

-0.64

AF347015.8

-0.75

-0.64

AF347015.31

-0.75

-0.64

AF347015.33

-0.74

-0.64

AF347015.27

-0.72

-0.66

MT-CYB

-0.72

-0.61

AF347015.2

-0.72

-0.61

HIGD1B

-0.71

-0.62

FXYD1

-0.70

-0.65

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004693

cyclin-dependent protein kinase activity

IEA

neuron (GO term level: 8)

GO:0000166

nucleotide binding

IEA

GO:0005524

ATP binding

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

TAS

1639063

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
TDRD7	KIAA1529 \| PCTAIRE2BP \| RP11-508D10.1 \| TRAP	tudor domain containing 7	Affinity Capture-Western	BioGRID	14603251
TDRD7	KIAA1529 \| PCTAIRE2BP \| RP11-508D10.1 \| TRAP	tudor domain containing 7	-	HPRD	10727952

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	428	434	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	428	434	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-141/200a	459	465	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	459	465	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-142-5p	1388	1394	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-149	225	231	m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/497	315	322	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-181	471	477	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-200bc/429	1354	1361	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-223	1584	1591	1A,m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-23	390	396	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	390	396	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24	507	513	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-378	1320	1326	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-381	1371	1377	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-409-3p	1293	1300	1A,m8	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-433-3p	1244	1251	1A,m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-503	316	322	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-542-3p	170	176	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.