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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: MED15

Summary

GeneID

51586

Symbol

MED15

Synonyms

ARC105|CAG7A|CTG7A|DKFZp686A2214|DKFZp762B1216|FLJ42282|FLJ42935|PCQAP|TIG-1|TIG1|TNRC7

Description

mediator complex subunit 15

Locus tag

Gene type

protein-coding

Map location

22q11.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

GSMA_I

genome scan meta-analysis

Psr: 0.031

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]

Click to show detail

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.02

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

16799563

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005794

Golgi apparatus

IDA

18029348

GO:0005634

nucleus

IEA

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATP5C1	ATP5C \| ATP5CL1	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	Two-hybrid	BioGRID	16169070
FHL3	MGC19547 \| MGC23614 \| MGC8696 \| SLIM2	four and a half LIM domains 3	Two-hybrid	BioGRID	16189514
MED10	L6 \| MGC5309 \| NUT2 \| TRG20	mediator complex subunit 10	Affinity Capture-MS	BioGRID	15175163
MED19	DT2P1G7 \| LCMR1	mediator complex subunit 19	Affinity Capture-MS	BioGRID	15175163
MED25	ACID1 \| ARC92 \| DKFZp434K0512 \| MGC70671 \| P78 \| PTOV2 \| TCBAP0758	mediator complex subunit 25	-	HPRD,BioGRID	14983011
MED26	CRSP7 \| CRSP70	mediator complex subunit 26	Affinity Capture-MS	BioGRID	15175163
MED28	1500003D12Rik \| DKFZp434N185 \| EG1 \| magicin	mediator complex subunit 28	Affinity Capture-MS	BioGRID	15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	Affinity Capture-MS	BioGRID	15175163
MED6	NY-REN-28	mediator complex subunit 6	Affinity Capture-MS	BioGRID	14983011
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	Affinity Capture-MS	BioGRID	15175163
MLLT6	AF17 \| FLJ23480	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	Two-hybrid	BioGRID	16189514
PLSCR1	MMTRA1B	phospholipid scramblase 1	Two-hybrid	BioGRID	16189514
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	-	HPRD	12167862
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	-	HPRD	12167862
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	-	HPRD	12167862

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_SMAD2_3NUCLEAR_PATHWAY	82	63	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION	104	72	All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	352	181	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS	478	302	All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM	168	115	All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	72	53	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP	783	507	All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP	276	187	All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER	214	139	All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS	183	115	All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP	566	371	All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN	457	302	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN	668	419	All SZGR genes in this pathway
QI_HYPOXIA_TARGETS_OF_HIF1A_AND_FOXA2	37	27	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	898	516	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE	1137	655	All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS	220	133	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	330	336	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	330	336	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-130/301	867	873	1A	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.