Gene Page: ERGIC3
Summary ?
| GeneID | 51614 |
| Symbol | ERGIC3 |
| Synonyms | C20orf47|CGI-54|Erv46|NY-BR-84|PRO0989|SDBCAG84|dJ477O4.2 |
| Description | ERGIC and golgi 3 |
| Reference | HGNC:HGNC:15927|Ensembl:ENSG00000125991|HPRD:15306|Vega:OTTHUMG00000032346 |
| Gene type | protein-coding |
| Map location | 20pter-q12 |
| Pascal p-value | 0.5 |
| Sherlock p-value | 0.752 |
| Fetal beta | 0.465 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Hippocampus |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg22818383 | 20 | 34129972 | ERGIC3 | 2.36E-11 | -0.014 | 3.47E-7 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6060625 | 20 | 34414318 | ERGIC3 | ENSG00000125991.14 | 1.43E-5 | 0.04 | 284548 | gtex_brain_ba24 |
| rs6060626 | 20 | 34415073 | ERGIC3 | ENSG00000125991.14 | 1.43E-5 | 0.04 | 285303 | gtex_brain_ba24 |
| rs150300484 | 20 | 34415193 | ERGIC3 | ENSG00000125991.14 | 1.43E-5 | 0.04 | 285423 | gtex_brain_ba24 |
| rs139840862 | 20 | 34417946 | ERGIC3 | ENSG00000125991.14 | 1.43E-5 | 0.04 | 288176 | gtex_brain_ba24 |
| rs6060632 | 20 | 34422601 | ERGIC3 | ENSG00000125991.14 | 1.43E-5 | 0.04 | 292831 | gtex_brain_ba24 |
| rs57182706 | 20 | 34422974 | ERGIC3 | ENSG00000125991.14 | 1.43E-5 | 0.04 | 293204 | gtex_brain_ba24 |
| rs12480111 | 20 | 34423186 | ERGIC3 | ENSG00000125991.14 | 1.43E-5 | 0.04 | 293416 | gtex_brain_ba24 |
| rs7272684 | 20 | 34424692 | ERGIC3 | ENSG00000125991.14 | 1.43E-5 | 0.04 | 294922 | gtex_brain_ba24 |
| rs141841650 | 20 | 34431377 | ERGIC3 | ENSG00000125991.14 | 1.43E-5 | 0.04 | 301607 | gtex_brain_ba24 |
| rs8116836 | 20 | 34453362 | ERGIC3 | ENSG00000125991.14 | 1.136E-5 | 0.04 | 323592 | gtex_brain_ba24 |
| rs374747486 | 20 | 34489481 | ERGIC3 | ENSG00000125991.14 | 1.206E-5 | 0.04 | 359711 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| BORCZUK MALIGNANT MESOTHELIOMA UP | 305 | 185 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP | 119 | 66 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP | 126 | 72 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
| BERENJENO TRANSFORMED BY RHOA DN | 394 | 258 | All SZGR 2.0 genes in this pathway |
| LUI THYROID CANCER PAX8 PPARG DN | 45 | 29 | All SZGR 2.0 genes in this pathway |
| LUI THYROID CANCER CLUSTER 3 | 28 | 16 | All SZGR 2.0 genes in this pathway |
| LUI TARGETS OF PAX8 PPARG FUSION | 34 | 23 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 UP | 309 | 199 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 20Q11 AMPLICON | 31 | 18 | All SZGR 2.0 genes in this pathway |
| KAAB HEART ATRIUM VS VENTRICLE UP | 249 | 170 | All SZGR 2.0 genes in this pathway |
| DAZARD RESPONSE TO UV NHEK UP | 244 | 151 | All SZGR 2.0 genes in this pathway |
| ZHOU TNF SIGNALING 30MIN | 54 | 36 | All SZGR 2.0 genes in this pathway |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP | 64 | 40 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS UP | 374 | 247 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12 | 79 | 54 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 2 UP | 140 | 94 | All SZGR 2.0 genes in this pathway |
| VANOEVELEN MYOGENESIS SIN3A TARGETS | 220 | 133 | All SZGR 2.0 genes in this pathway |