Gene Page

Home
Datasets
Search
Analysis & Tools
Documents
About SZGR
Quick search: (e.g. 207 or AKT)

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

Release Site Map Support Contact us

Gene Page: PDPK1

Summary

GeneID

5170

Symbol

PDPK1

Synonyms

MGC20087|MGC35290|PDK1|PRO0461

Description

3-phosphoinositide dependent protein kinase-1

Locus tag

Gene type

protein-coding

Map location

16p13.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1365

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

HYPK

0.90

SUMO2

0.89

0.87

C19orf43

0.89

0.83

FAM32A

0.87

0.84

TMSB10

0.86

0.81

AARSD1

0.85

0.84

U2AF1

0.85

0.84

PQBP1

0.85

0.81

SNRPF

0.85

0.82

AC106037.2

0.85

0.82

Top 10 negatively co-expressed genes

TINAGL1

-0.65

-0.74

HLA-F

-0.62

-0.68

AF347015.33

-0.60

-0.68

AF347015.9

-0.58

-0.72

FGR

-0.58

-0.67

HLA-E

-0.58

-0.63

ATP10A

-0.58

-0.64

MT-CO2

-0.58

-0.64

AF347015.27

-0.58

-0.66

TSC22D4

-0.57

-0.64

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005515

protein binding

IPI

14749367

GO:0005524

ATP binding

IEA

GO:0004672

protein kinase activity

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0004676

3-phosphoinositide-dependent protein kinase activity

TAS

9368760

GO:0004197

cysteine-type endopeptidase activity

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006468

protein amino acid phosphorylation

TAS

9368760

GO:0006508

proteolysis

IEA

GO:0007242

intracellular signaling cascade

IDA

14749367

GO:0008286

insulin receptor signaling pathway

TAS

10792047

GO:0030036

actin cytoskeleton organization

TAS

10792047

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

10698680

GO:0005737

cytoplasm

IDA

9637919

GO:0005886

plasma membrane

EXP

9381178 |9812896 |10485710
|10698680 |11715018
|12167717 |12244303
|12524439 |15122200
|15125833 |15541657
|157

GO:0005886

plasma membrane

IDA

9637919

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	11825911
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	PDK1 phosphorylates Akt1.	BIND	15718470
AKTIP	FT1 \| FTS	AKT interacting protein	-	HPRD	14749367
CARD11	BIMP3 \| CARMA1 \| MGC133069	caspase recruitment domain family, member 11	PDK1 interacts with CARD11.	BIND	15802604
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD	11779851
PDPK1	MGC20087 \| MGC35290 \| PDK1 \| PRO0461	3-phosphoinositide dependent protein kinase-1	Biochemical Activity	BioGRID	10856237
PKN1	DBK \| MGC46204 \| PAK1 \| PKN \| PKN-ALPHA \| PRK1 \| PRKCL1	protein kinase N1	-	HPRD,BioGRID	10764742
PKN2	MGC150606 \| MGC71074 \| PAK2 \| PRK2 \| PRKCL2 \| PRO2042 \| Pak-2	protein kinase N2	-	HPRD	10753910
			PKN2 (PRK2) interacts with PDPK1 (PDK1). This interaction was modelled on a demonstrated interaction between human PKN2 and rat PDPK1.	BIND	11781095
			Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10764742 \|11781095
PRKACA	MGC102831 \| MGC48865 \| PKACA	protein kinase, cAMP-dependent, catalytic, alpha	Reconstituted Complex Two-hybrid	BioGRID	10698939
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	-	HPRD,BioGRID	11376011
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	-	HPRD,BioGRID	11781095
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	PRKCD (PKCD) interacts with PDPK1 (PDK1). This interaction was modelled on a demonstrated interaction between human PRKCD and rat PDPK1.	BIND	11781095
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCE (PKC-epsilon). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCE from an unspecified species.	BIND	12223477
PRKCH	MGC26269 \| MGC5363 \| PKC-L \| PKCL \| PRKCL \| nPKC-eta	protein kinase C, eta	An unspecified isoform of PDPK1 (PDK1) interacts with and phosphorylates PRKCH (PKC-eta). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCH from an unspecified species.	BIND	12223477
PRKCI	DXS1179E \| MGC26534 \| PKCI \| nPKC-iota	protein kinase C, iota	-	HPRD,BioGRID	10764742
PRKCQ	MGC126514 \| MGC141919 \| PRKCT \| nPKC-theta	protein kinase C, theta	PDK1 interacts with PKC-theta.	BIND	15802604
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	PRKCZ (PKCZ) interacts with PDPK1 (PDK1). This interaction was modelled on a demonstrated interaction between human PRKCZ and rat PDPK1.	BIND	11781095
			An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCZ (PKC-zeta). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCZ from an unspecified species.	BIND	12223477
			-	HPRD,BioGRID	9748166 \|10764742 \|11781095
PRSS23	MGC5107 \| SIG13 \| SPUVE \| ZSIG13	protease, serine, 23	Two-hybrid	BioGRID	16169070
RALGDS	FLJ20922 \| RGF \| RalGEF	ral guanine nucleotide dissociation stimulator	-	HPRD	11889038
RPS6KA3	CLS \| HU-3 \| ISPK-1 \| MAPKAPK1B \| MRX19 \| RSK \| RSK2 \| S6K-alpha3 \| p90-RSK2 \| pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3	-	HPRD,BioGRID	10856237
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	-	HPRD	11438723
SGK1	SGK	serum/glucocorticoid regulated kinase 1	-	HPRD,BioGRID	10357815
SLC9A3R2	E3KARP \| MGC104639 \| NHE3RF2 \| NHERF-2 \| NHERF2 \| OCTS2 \| SIP-1 \| SIP1 \| TKA-1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	-	HPRD,BioGRID	12387817
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	-	HPRD,BioGRID	12177059
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	-	HPRD,BioGRID	12177059

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	3050	3057	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
				hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-140	167	173	1A	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-200bc/429	4868	4874	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-223	3773	3779	m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-27	4990	4996	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
				hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
				hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-33	5037	5043	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	5037	5043	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-369-3p	5259	5265	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	5259	5265	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-375	178	184	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-382	5240	5246	m8	hsa-miR-382^brain	GAAGUUGUUCGUGGUGGAUUCG
miR-410	5078	5084	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-410	5078	5084	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-493-5p	4996	5002	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-493-5p	4996	5002	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-505	3767	3774	1A,m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.