Gene Page: PEX6
Summary ?
| GeneID | 5190 |
| Symbol | PEX6 |
| Synonyms | HMLR2|PAF-2|PAF2|PBD4A|PDB4B|PXAAA1 |
| Description | peroxisomal biogenesis factor 6 |
| Reference | MIM:601498|HGNC:HGNC:8859|Ensembl:ENSG00000124587|HPRD:03293|Vega:OTTHUMG00000014713 |
| Gene type | protein-coding |
| Map location | 6p21.1 |
| Pascal p-value | 0.717 |
| Sherlock p-value | 0.923 |
| DMG | 2 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.04433 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg18889437 | 6 | 42947671 | PEX6 | 2.577E-4 | -0.541 | 0.038 | DMG:Wockner_2014 |
| cg03790207 | 6 | 42947109 | PEX6 | 1.1E-7 | -0.007 | 2.38E-5 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9367149 | chr6 | 42478214 | PEX6 | 5190 | 0.04 | cis | ||
| rs9381185 | chr6 | 42478280 | PEX6 | 5190 | 0.15 | cis | ||
| rs9394931 | chr6 | 42873244 | PEX6 | 5190 | 1.656E-7 | cis | ||
| rs9296401 | chr6 | 42875464 | PEX6 | 5190 | 1.895E-4 | cis | ||
| rs6936722 | chr6 | 42891310 | PEX6 | 5190 | 2.624E-5 | cis | ||
| rs6941212 | chr6 | 42915919 | PEX6 | 5190 | 1.016E-16 | cis | ||
| rs2274517 | chr6 | 42932714 | PEX6 | 5190 | 1.328E-22 | cis | ||
| rs17062854 | chr5 | 163473502 | PEX6 | 5190 | 0.19 | trans | ||
| rs9394931 | chr6 | 42873244 | PEX6 | 5190 | 3.593E-5 | trans | ||
| rs9296401 | chr6 | 42875464 | PEX6 | 5190 | 0.02 | trans | ||
| rs6936722 | chr6 | 42891310 | PEX6 | 5190 | 0 | trans | ||
| rs6941212 | chr6 | 42915919 | PEX6 | 5190 | 2.45E-14 | trans | ||
| rs2274517 | chr6 | 42932714 | PEX6 | 5190 | 2.076E-20 | trans | ||
| rs2234185 | 6 | 42897074 | PEX6 | ENSG00000124587.9 | 1.24E-6 | 0 | 49884 | gtex_brain_ba24 |
| rs4711731 | 6 | 42897712 | PEX6 | ENSG00000124587.9 | 8.515E-8 | 0 | 49246 | gtex_brain_ba24 |
| rs4714634 | 6 | 42901120 | PEX6 | ENSG00000124587.9 | 1.829E-10 | 0 | 45838 | gtex_brain_ba24 |
| rs3763236 | 6 | 42902508 | PEX6 | ENSG00000124587.9 | 5.535E-10 | 0 | 44450 | gtex_brain_ba24 |
| rs1053538 | 6 | 42903763 | PEX6 | ENSG00000124587.9 | 3.415E-10 | 0 | 43195 | gtex_brain_ba24 |
| rs1053539 | 6 | 42903766 | PEX6 | ENSG00000124587.9 | 4.657E-10 | 0 | 43192 | gtex_brain_ba24 |
| rs6458312 | 6 | 42904274 | PEX6 | ENSG00000124587.9 | 1.264E-8 | 0 | 42684 | gtex_brain_ba24 |
| rs9471968 | 6 | 42905235 | PEX6 | ENSG00000124587.9 | 1.053E-8 | 0 | 41723 | gtex_brain_ba24 |
| rs9471972 | 6 | 42915021 | PEX6 | ENSG00000124587.9 | 7.214E-10 | 0 | 31937 | gtex_brain_ba24 |
| rs7770760 | 6 | 42915403 | PEX6 | ENSG00000124587.9 | 1.145E-9 | 0 | 31555 | gtex_brain_ba24 |
| rs6941212 | 6 | 42915920 | PEX6 | ENSG00000124587.9 | 2.451E-10 | 0 | 31038 | gtex_brain_ba24 |
| rs4714638 | 6 | 42917017 | PEX6 | ENSG00000124587.9 | 2.344E-10 | 0 | 29941 | gtex_brain_ba24 |
| rs9471974 | 6 | 42918984 | PEX6 | ENSG00000124587.9 | 4.441E-11 | 0 | 27974 | gtex_brain_ba24 |
| rs9471975 | 6 | 42919222 | PEX6 | ENSG00000124587.9 | 2.662E-11 | 0 | 27736 | gtex_brain_ba24 |
| rs2104616 | 6 | 42919969 | PEX6 | ENSG00000124587.9 | 1.456E-11 | 0 | 26989 | gtex_brain_ba24 |
| rs59824590 | 6 | 42920416 | PEX6 | ENSG00000124587.9 | 2.869E-11 | 0 | 26542 | gtex_brain_ba24 |
| rs9471976 | 6 | 42920549 | PEX6 | ENSG00000124587.9 | 3.84E-11 | 0 | 26409 | gtex_brain_ba24 |
| rs4469287 | 6 | 42920844 | PEX6 | ENSG00000124587.9 | 4.746E-11 | 0 | 26114 | gtex_brain_ba24 |
| rs28868299 | 6 | 42921221 | PEX6 | ENSG00000124587.9 | 1.76E-11 | 0 | 25737 | gtex_brain_ba24 |
| rs145239038 | 6 | 42921474 | PEX6 | ENSG00000124587.9 | 1.464E-10 | 0 | 25484 | gtex_brain_ba24 |
| rs202000850 | 6 | 42921489 | PEX6 | ENSG00000124587.9 | 7.777E-8 | 0 | 25469 | gtex_brain_ba24 |
| rs58497441 | 6 | 42921561 | PEX6 | ENSG00000124587.9 | 4.38E-11 | 0 | 25397 | gtex_brain_ba24 |
| rs56108053 | 6 | 42921673 | PEX6 | ENSG00000124587.9 | 5.458E-11 | 0 | 25285 | gtex_brain_ba24 |
| rs6458313 | 6 | 42922018 | PEX6 | ENSG00000124587.9 | 1.569E-11 | 0 | 24940 | gtex_brain_ba24 |
| rs6458314 | 6 | 42922215 | PEX6 | ENSG00000124587.9 | 2.661E-11 | 0 | 24743 | gtex_brain_ba24 |
| rs201064887 | 6 | 42922358 | PEX6 | ENSG00000124587.9 | 4.802E-7 | 0 | 24600 | gtex_brain_ba24 |
| rs35908551 | 6 | 42922360 | PEX6 | ENSG00000124587.9 | 1.841E-8 | 0 | 24598 | gtex_brain_ba24 |
| rs6458315 | 6 | 42922547 | PEX6 | ENSG00000124587.9 | 4.249E-11 | 0 | 24411 | gtex_brain_ba24 |
| rs12524845 | 6 | 42923902 | PEX6 | ENSG00000124587.9 | 4.615E-11 | 0 | 23056 | gtex_brain_ba24 |
| rs112122607 | 6 | 42924041 | PEX6 | ENSG00000124587.9 | 4.667E-11 | 0 | 22917 | gtex_brain_ba24 |
| rs13215983 | 6 | 42924193 | PEX6 | ENSG00000124587.9 | 4.724E-11 | 0 | 22765 | gtex_brain_ba24 |
| rs13216214 | 6 | 42924247 | PEX6 | ENSG00000124587.9 | 4.75E-11 | 0 | 22711 | gtex_brain_ba24 |
| rs4714640 | 6 | 42924424 | PEX6 | ENSG00000124587.9 | 4.865E-11 | 0 | 22534 | gtex_brain_ba24 |
| rs70990160 | 6 | 42924488 | PEX6 | ENSG00000124587.9 | 4.796E-11 | 0 | 22470 | gtex_brain_ba24 |
| rs4714641 | 6 | 42924622 | PEX6 | ENSG00000124587.9 | 4.921E-11 | 0 | 22336 | gtex_brain_ba24 |
| rs56038104 | 6 | 42924894 | PEX6 | ENSG00000124587.9 | 3.189E-10 | 0 | 22064 | gtex_brain_ba24 |
| rs6940814 | 6 | 42924932 | PEX6 | ENSG00000124587.9 | 1.791E-10 | 0 | 22026 | gtex_brain_ba24 |
| rs6920547 | 6 | 42924955 | PEX6 | ENSG00000124587.9 | 5.274E-11 | 0 | 22003 | gtex_brain_ba24 |
| rs6940837 | 6 | 42924969 | PEX6 | ENSG00000124587.9 | 5.252E-11 | 0 | 21989 | gtex_brain_ba24 |
| rs9296403 | 6 | 42925683 | PEX6 | ENSG00000124587.9 | 1.094E-10 | 0 | 21275 | gtex_brain_ba24 |
| rs9296404 | 6 | 42925803 | PEX6 | ENSG00000124587.9 | 5.892E-11 | 0 | 21155 | gtex_brain_ba24 |
| rs9462855 | 6 | 42925936 | PEX6 | ENSG00000124587.9 | 6E-11 | 0 | 21022 | gtex_brain_ba24 |
| rs9462856 | 6 | 42926024 | PEX6 | ENSG00000124587.9 | 2.384E-11 | 0 | 20934 | gtex_brain_ba24 |
| rs370513007 | 6 | 42926477 | PEX6 | ENSG00000124587.9 | 1.343E-10 | 0 | 20481 | gtex_brain_ba24 |
| rs11752813 | 6 | 42928017 | PEX6 | ENSG00000124587.9 | 1.796E-10 | 0 | 18941 | gtex_brain_ba24 |
| rs10948059 | 6 | 42928461 | PEX6 | ENSG00000124587.9 | 2.865E-11 | 0 | 18497 | gtex_brain_ba24 |
| rs2296805 | 6 | 42928758 | PEX6 | ENSG00000124587.9 | 6.519E-11 | 0 | 18200 | gtex_brain_ba24 |
| rs9471978 | 6 | 42929533 | PEX6 | ENSG00000124587.9 | 1.257E-10 | 0 | 17425 | gtex_brain_ba24 |
| rs7760250 | 6 | 42929839 | PEX6 | ENSG00000124587.9 | 9.727E-11 | 0 | 17119 | gtex_brain_ba24 |
| rs4987173 | 6 | 42931224 | PEX6 | ENSG00000124587.9 | 2.585E-10 | 0 | 15734 | gtex_brain_ba24 |
| rs2296804 | 6 | 42931261 | PEX6 | ENSG00000124587.9 | 8.633E-11 | 0 | 15697 | gtex_brain_ba24 |
| rs5875822 | 6 | 42931627 | PEX6 | ENSG00000124587.9 | 8.972E-11 | 0 | 15331 | gtex_brain_ba24 |
| rs1129187 | 6 | 42932200 | PEX6 | ENSG00000124587.9 | 2.922E-10 | 0 | 14758 | gtex_brain_ba24 |
| rs1129186 | 6 | 42932202 | PEX6 | ENSG00000124587.9 | 1.294E-10 | 0 | 14756 | gtex_brain_ba24 |
| rs2274517 | 6 | 42932715 | PEX6 | ENSG00000124587.9 | 1.304E-10 | 0 | 14243 | gtex_brain_ba24 |
| rs2274514 | 6 | 42934500 | PEX6 | ENSG00000124587.9 | 3.056E-11 | 0 | 12458 | gtex_brain_ba24 |
| rs3818554 | 6 | 42934620 | PEX6 | ENSG00000124587.9 | 1.287E-11 | 0 | 12338 | gtex_brain_ba24 |
| rs4714644 | 6 | 42934818 | PEX6 | ENSG00000124587.9 | 2.8E-11 | 0 | 12140 | gtex_brain_ba24 |
| rs9471982 | 6 | 42935998 | PEX6 | ENSG00000124587.9 | 1.304E-10 | 0 | 10960 | gtex_brain_ba24 |
| rs3805953 | 6 | 42936900 | PEX6 | ENSG00000124587.9 | 5.52E-12 | 0 | 10058 | gtex_brain_ba24 |
| rs3805952 | 6 | 42937126 | PEX6 | ENSG00000124587.9 | 3.459E-11 | 0 | 9832 | gtex_brain_ba24 |
| rs3805951 | 6 | 42937176 | PEX6 | ENSG00000124587.9 | 3.365E-11 | 0 | 9782 | gtex_brain_ba24 |
| rs3293 | 6 | 42938377 | PEX6 | ENSG00000124587.9 | 1.287E-11 | 0 | 8581 | gtex_brain_ba24 |
| rs10948061 | 6 | 42940235 | PEX6 | ENSG00000124587.9 | 3.363E-11 | 0 | 6723 | gtex_brain_ba24 |
| rs9471983 | 6 | 42940365 | PEX6 | ENSG00000124587.9 | 3.363E-11 | 0 | 6593 | gtex_brain_ba24 |
| rs200189441 | 6 | 42940524 | PEX6 | ENSG00000124587.9 | 2.122E-11 | 0 | 6434 | gtex_brain_ba24 |
| rs570622275 | 6 | 42940525 | PEX6 | ENSG00000124587.9 | 1.291E-11 | 0 | 6433 | gtex_brain_ba24 |
| rs2395943 | 6 | 42940673 | PEX6 | ENSG00000124587.9 | 1.008E-11 | 0 | 6285 | gtex_brain_ba24 |
| rs9296406 | 6 | 42940810 | PEX6 | ENSG00000124587.9 | 4.628E-12 | 0 | 6148 | gtex_brain_ba24 |
| rs9471985 | 6 | 42941324 | PEX6 | ENSG00000124587.9 | 1.282E-11 | 0 | 5634 | gtex_brain_ba24 |
| rs71855084 | 6 | 42942180 | PEX6 | ENSG00000124587.9 | 9.294E-9 | 0 | 4778 | gtex_brain_ba24 |
| rs9296407 | 6 | 42942451 | PEX6 | ENSG00000124587.9 | 1.284E-11 | 0 | 4507 | gtex_brain_ba24 |
| rs9986447 | 6 | 42942779 | PEX6 | ENSG00000124587.9 | 6.149E-11 | 0 | 4179 | gtex_brain_ba24 |
| rs9462857 | 6 | 42943098 | PEX6 | ENSG00000124587.9 | 3.362E-11 | 0 | 3860 | gtex_brain_ba24 |
| rs9471986 | 6 | 42944127 | PEX6 | ENSG00000124587.9 | 2.25E-11 | 0 | 2831 | gtex_brain_ba24 |
| rs9471987 | 6 | 42944140 | PEX6 | ENSG00000124587.9 | 5.931E-11 | 0 | 2818 | gtex_brain_ba24 |
| rs9471988 | 6 | 42944773 | PEX6 | ENSG00000124587.9 | 1.809E-11 | 0 | 2185 | gtex_brain_ba24 |
| rs6907751 | 6 | 42944850 | PEX6 | ENSG00000124587.9 | 1.219E-11 | 0 | 2108 | gtex_brain_ba24 |
| rs200735142 | 6 | 42944988 | PEX6 | ENSG00000124587.9 | 8.467E-12 | 0 | 1970 | gtex_brain_ba24 |
| rs201802248 | 6 | 42945582 | PEX6 | ENSG00000124587.9 | 6.342E-12 | 0 | 1376 | gtex_brain_ba24 |
| rs199921136 | 6 | 42945583 | PEX6 | ENSG00000124587.9 | 6.787E-11 | 0 | 1375 | gtex_brain_ba24 |
| rs9296408 | 6 | 42945584 | PEX6 | ENSG00000124587.9 | 5.964E-12 | 0 | 1374 | gtex_brain_ba24 |
| rs9462858 | 6 | 42946490 | PEX6 | ENSG00000124587.9 | 4.658E-10 | 0 | 468 | gtex_brain_ba24 |
| rs9462859 | 6 | 42946943 | PEX6 | ENSG00000124587.9 | 4.803E-10 | 0 | 15 | gtex_brain_ba24 |
| rs9462860 | 6 | 42947013 | PEX6 | ENSG00000124587.9 | 6.192E-11 | 0 | -55 | gtex_brain_ba24 |
| rs3805946 | 6 | 42955749 | PEX6 | ENSG00000124587.9 | 1.861E-12 | 0 | -8791 | gtex_brain_ba24 |
| rs11757495 | 6 | 43037061 | PEX6 | ENSG00000124587.9 | 2.359E-6 | 0 | -90103 | gtex_brain_ba24 |
| rs13199873 | 6 | 43040368 | PEX6 | ENSG00000124587.9 | 2.35E-7 | 0 | -93410 | gtex_brain_ba24 |
| rs2007950 | 6 | 43049461 | PEX6 | ENSG00000124587.9 | 3.618E-8 | 0 | -102503 | gtex_brain_ba24 |
| rs4711731 | 6 | 42897712 | PEX6 | ENSG00000124587.9 | 3.677E-6 | 0 | 49246 | gtex_brain_putamen_basal |
| rs4714634 | 6 | 42901120 | PEX6 | ENSG00000124587.9 | 4.717E-10 | 0 | 45838 | gtex_brain_putamen_basal |
| rs3763236 | 6 | 42902508 | PEX6 | ENSG00000124587.9 | 9.95E-8 | 0 | 44450 | gtex_brain_putamen_basal |
| rs1053538 | 6 | 42903763 | PEX6 | ENSG00000124587.9 | 6.74E-8 | 0 | 43195 | gtex_brain_putamen_basal |
| rs1053539 | 6 | 42903766 | PEX6 | ENSG00000124587.9 | 6.932E-8 | 0 | 43192 | gtex_brain_putamen_basal |
| rs6458312 | 6 | 42904274 | PEX6 | ENSG00000124587.9 | 4.85E-8 | 0 | 42684 | gtex_brain_putamen_basal |
| rs9471968 | 6 | 42905235 | PEX6 | ENSG00000124587.9 | 4.699E-8 | 0 | 41723 | gtex_brain_putamen_basal |
| rs9471972 | 6 | 42915021 | PEX6 | ENSG00000124587.9 | 1.624E-11 | 0 | 31937 | gtex_brain_putamen_basal |
| rs7770760 | 6 | 42915403 | PEX6 | ENSG00000124587.9 | 2.176E-9 | 0 | 31555 | gtex_brain_putamen_basal |
| rs6941212 | 6 | 42915920 | PEX6 | ENSG00000124587.9 | 3.282E-10 | 0 | 31038 | gtex_brain_putamen_basal |
| rs4714638 | 6 | 42917017 | PEX6 | ENSG00000124587.9 | 3.316E-11 | 0 | 29941 | gtex_brain_putamen_basal |
| rs9471974 | 6 | 42918984 | PEX6 | ENSG00000124587.9 | 8.373E-11 | 0 | 27974 | gtex_brain_putamen_basal |
| rs9471975 | 6 | 42919222 | PEX6 | ENSG00000124587.9 | 7.775E-10 | 0 | 27736 | gtex_brain_putamen_basal |
| rs2104616 | 6 | 42919969 | PEX6 | ENSG00000124587.9 | 8.916E-11 | 0 | 26989 | gtex_brain_putamen_basal |
| rs59824590 | 6 | 42920416 | PEX6 | ENSG00000124587.9 | 7.42E-10 | 0 | 26542 | gtex_brain_putamen_basal |
| rs9471976 | 6 | 42920549 | PEX6 | ENSG00000124587.9 | 5.41E-10 | 0 | 26409 | gtex_brain_putamen_basal |
| rs4469287 | 6 | 42920844 | PEX6 | ENSG00000124587.9 | 6.804E-10 | 0 | 26114 | gtex_brain_putamen_basal |
| rs28868299 | 6 | 42921221 | PEX6 | ENSG00000124587.9 | 4.015E-11 | 0 | 25737 | gtex_brain_putamen_basal |
| rs145239038 | 6 | 42921474 | PEX6 | ENSG00000124587.9 | 3.388E-9 | 0 | 25484 | gtex_brain_putamen_basal |
| rs202000850 | 6 | 42921489 | PEX6 | ENSG00000124587.9 | 3.911E-7 | 0 | 25469 | gtex_brain_putamen_basal |
| rs58497441 | 6 | 42921561 | PEX6 | ENSG00000124587.9 | 3.024E-10 | 0 | 25397 | gtex_brain_putamen_basal |
| rs56108053 | 6 | 42921673 | PEX6 | ENSG00000124587.9 | 6.81E-11 | 0 | 25285 | gtex_brain_putamen_basal |
| rs6458313 | 6 | 42922018 | PEX6 | ENSG00000124587.9 | 3.762E-11 | 0 | 24940 | gtex_brain_putamen_basal |
| rs6458314 | 6 | 42922215 | PEX6 | ENSG00000124587.9 | 9.434E-10 | 0 | 24743 | gtex_brain_putamen_basal |
| rs6458315 | 6 | 42922547 | PEX6 | ENSG00000124587.9 | 3.438E-10 | 0 | 24411 | gtex_brain_putamen_basal |
| rs12524845 | 6 | 42923902 | PEX6 | ENSG00000124587.9 | 4.451E-10 | 0 | 23056 | gtex_brain_putamen_basal |
| rs112122607 | 6 | 42924041 | PEX6 | ENSG00000124587.9 | 4.411E-10 | 0 | 22917 | gtex_brain_putamen_basal |
| rs13215983 | 6 | 42924193 | PEX6 | ENSG00000124587.9 | 4.367E-10 | 0 | 22765 | gtex_brain_putamen_basal |
| rs13216214 | 6 | 42924247 | PEX6 | ENSG00000124587.9 | 4.351E-10 | 0 | 22711 | gtex_brain_putamen_basal |
| rs4714640 | 6 | 42924424 | PEX6 | ENSG00000124587.9 | 4.276E-10 | 0 | 22534 | gtex_brain_putamen_basal |
| rs70990160 | 6 | 42924488 | PEX6 | ENSG00000124587.9 | 2.869E-10 | 0 | 22470 | gtex_brain_putamen_basal |
| rs4714641 | 6 | 42924622 | PEX6 | ENSG00000124587.9 | 4.312E-10 | 0 | 22336 | gtex_brain_putamen_basal |
| rs56038104 | 6 | 42924894 | PEX6 | ENSG00000124587.9 | 8.038E-10 | 0 | 22064 | gtex_brain_putamen_basal |
| rs6940814 | 6 | 42924932 | PEX6 | ENSG00000124587.9 | 3.707E-7 | 0 | 22026 | gtex_brain_putamen_basal |
| rs6920547 | 6 | 42924955 | PEX6 | ENSG00000124587.9 | 3.086E-10 | 0 | 22003 | gtex_brain_putamen_basal |
| rs6940837 | 6 | 42924969 | PEX6 | ENSG00000124587.9 | 4.302E-10 | 0 | 21989 | gtex_brain_putamen_basal |
| rs9296403 | 6 | 42925683 | PEX6 | ENSG00000124587.9 | 2.927E-11 | 0 | 21275 | gtex_brain_putamen_basal |
| rs9296404 | 6 | 42925803 | PEX6 | ENSG00000124587.9 | 3.783E-10 | 0 | 21155 | gtex_brain_putamen_basal |
| rs9462855 | 6 | 42925936 | PEX6 | ENSG00000124587.9 | 3.748E-10 | 0 | 21022 | gtex_brain_putamen_basal |
| rs9462856 | 6 | 42926024 | PEX6 | ENSG00000124587.9 | 2.603E-11 | 0 | 20934 | gtex_brain_putamen_basal |
| rs370513007 | 6 | 42926477 | PEX6 | ENSG00000124587.9 | 5.17E-11 | 0 | 20481 | gtex_brain_putamen_basal |
| rs11752813 | 6 | 42928017 | PEX6 | ENSG00000124587.9 | 4.85E-11 | 0 | 18941 | gtex_brain_putamen_basal |
| rs10948059 | 6 | 42928461 | PEX6 | ENSG00000124587.9 | 4.065E-9 | 0 | 18497 | gtex_brain_putamen_basal |
| rs2296805 | 6 | 42928758 | PEX6 | ENSG00000124587.9 | 5.181E-10 | 0 | 18200 | gtex_brain_putamen_basal |
| rs9471978 | 6 | 42929533 | PEX6 | ENSG00000124587.9 | 1.389E-9 | 0 | 17425 | gtex_brain_putamen_basal |
| rs7760250 | 6 | 42929839 | PEX6 | ENSG00000124587.9 | 3.172E-10 | 0 | 17119 | gtex_brain_putamen_basal |
| rs4987173 | 6 | 42931224 | PEX6 | ENSG00000124587.9 | 4.69E-11 | 0 | 15734 | gtex_brain_putamen_basal |
| rs2296804 | 6 | 42931261 | PEX6 | ENSG00000124587.9 | 5.111E-10 | 0 | 15697 | gtex_brain_putamen_basal |
| rs5875822 | 6 | 42931627 | PEX6 | ENSG00000124587.9 | 5.072E-10 | 0 | 15331 | gtex_brain_putamen_basal |
| rs1129187 | 6 | 42932200 | PEX6 | ENSG00000124587.9 | 4.658E-11 | 0 | 14758 | gtex_brain_putamen_basal |
| rs1129186 | 6 | 42932202 | PEX6 | ENSG00000124587.9 | 3.039E-10 | 0 | 14756 | gtex_brain_putamen_basal |
| rs2274517 | 6 | 42932715 | PEX6 | ENSG00000124587.9 | 2.212E-10 | 0 | 14243 | gtex_brain_putamen_basal |
| rs2274514 | 6 | 42934500 | PEX6 | ENSG00000124587.9 | 4.525E-10 | 0 | 12458 | gtex_brain_putamen_basal |
| rs3818554 | 6 | 42934620 | PEX6 | ENSG00000124587.9 | 7.566E-10 | 0 | 12338 | gtex_brain_putamen_basal |
| rs4714644 | 6 | 42934818 | PEX6 | ENSG00000124587.9 | 3.478E-10 | 0 | 12140 | gtex_brain_putamen_basal |
| rs9471982 | 6 | 42935998 | PEX6 | ENSG00000124587.9 | 2.212E-10 | 0 | 10960 | gtex_brain_putamen_basal |
| rs3805953 | 6 | 42936900 | PEX6 | ENSG00000124587.9 | 5.519E-11 | 0 | 10058 | gtex_brain_putamen_basal |
| rs3805952 | 6 | 42937126 | PEX6 | ENSG00000124587.9 | 1.018E-10 | 0 | 9832 | gtex_brain_putamen_basal |
| rs3805951 | 6 | 42937176 | PEX6 | ENSG00000124587.9 | 1.043E-10 | 0 | 9782 | gtex_brain_putamen_basal |
| rs3293 | 6 | 42938377 | PEX6 | ENSG00000124587.9 | 5.4E-10 | 0 | 8581 | gtex_brain_putamen_basal |
| rs10948061 | 6 | 42940235 | PEX6 | ENSG00000124587.9 | 1.043E-10 | 0 | 6723 | gtex_brain_putamen_basal |
| rs9471983 | 6 | 42940365 | PEX6 | ENSG00000124587.9 | 1.043E-10 | 0 | 6593 | gtex_brain_putamen_basal |
| rs200189441 | 6 | 42940524 | PEX6 | ENSG00000124587.9 | 1.014E-10 | 0 | 6434 | gtex_brain_putamen_basal |
| rs570622275 | 6 | 42940525 | PEX6 | ENSG00000124587.9 | 5.377E-10 | 0 | 6433 | gtex_brain_putamen_basal |
| rs2395943 | 6 | 42940673 | PEX6 | ENSG00000124587.9 | 9.331E-10 | 0 | 6285 | gtex_brain_putamen_basal |
| rs9296406 | 6 | 42940810 | PEX6 | ENSG00000124587.9 | 7.731E-11 | 0 | 6148 | gtex_brain_putamen_basal |
| rs9471985 | 6 | 42941324 | PEX6 | ENSG00000124587.9 | 5.411E-10 | 0 | 5634 | gtex_brain_putamen_basal |
| rs71855084 | 6 | 42942180 | PEX6 | ENSG00000124587.9 | 2.65E-11 | 0 | 4778 | gtex_brain_putamen_basal |
| rs9296407 | 6 | 42942451 | PEX6 | ENSG00000124587.9 | 5.435E-10 | 0 | 4507 | gtex_brain_putamen_basal |
| rs9986447 | 6 | 42942779 | PEX6 | ENSG00000124587.9 | 5.987E-12 | 0 | 4179 | gtex_brain_putamen_basal |
| rs9462857 | 6 | 42943098 | PEX6 | ENSG00000124587.9 | 1.062E-10 | 0 | 3860 | gtex_brain_putamen_basal |
| rs9471986 | 6 | 42944127 | PEX6 | ENSG00000124587.9 | 3.624E-9 | 0 | 2831 | gtex_brain_putamen_basal |
| rs9471987 | 6 | 42944140 | PEX6 | ENSG00000124587.9 | 1.877E-8 | 0 | 2818 | gtex_brain_putamen_basal |
| rs9471988 | 6 | 42944773 | PEX6 | ENSG00000124587.9 | 4.204E-10 | 0 | 2185 | gtex_brain_putamen_basal |
| rs6907751 | 6 | 42944850 | PEX6 | ENSG00000124587.9 | 1.247E-8 | 0 | 2108 | gtex_brain_putamen_basal |
| rs200735142 | 6 | 42944988 | PEX6 | ENSG00000124587.9 | 5.838E-11 | 0 | 1970 | gtex_brain_putamen_basal |
| rs201802248 | 6 | 42945582 | PEX6 | ENSG00000124587.9 | 6.25E-8 | 0 | 1376 | gtex_brain_putamen_basal |
| rs199921136 | 6 | 42945583 | PEX6 | ENSG00000124587.9 | 6.154E-8 | 0 | 1375 | gtex_brain_putamen_basal |
| rs9296408 | 6 | 42945584 | PEX6 | ENSG00000124587.9 | 9.791E-7 | 0 | 1374 | gtex_brain_putamen_basal |
| rs9462858 | 6 | 42946490 | PEX6 | ENSG00000124587.9 | 3.836E-10 | 0 | 468 | gtex_brain_putamen_basal |
| rs9462859 | 6 | 42946943 | PEX6 | ENSG00000124587.9 | 3.851E-10 | 0 | 15 | gtex_brain_putamen_basal |
| rs9462860 | 6 | 42947013 | PEX6 | ENSG00000124587.9 | 1.444E-9 | 0 | -55 | gtex_brain_putamen_basal |
| rs3805946 | 6 | 42955749 | PEX6 | ENSG00000124587.9 | 3.135E-10 | 0 | -8791 | gtex_brain_putamen_basal |
| rs2007950 | 6 | 43049461 | PEX6 | ENSG00000124587.9 | 2.545E-6 | 0 | -102503 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0005524 | ATP binding | IMP | 16854980 | |
| GO:0008022 | protein C-terminus binding | IPI | 16854980 | |
| GO:0017111 | nucleoside-triphosphatase activity | IEA | - | |
| GO:0032403 | protein complex binding | IDA | 16854980 | |
| GO:0042623 | ATPase activity, coupled | IMP | 16854980 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006625 | protein targeting to peroxisome | IMP | 16854980 | |
| GO:0016561 | protein import into peroxisome matrix, translocation | IMP | 8670792 | |
| GO:0050821 | protein stabilization | IMP | 8670792 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | IDA | 16854980 | |
| GO:0005737 | cytoplasm | IDA | 8670792 | |
| GO:0005777 | peroxisome | IDA | 11439091 |16854980 | |
| GO:0005778 | peroxisomal membrane | IEA | - | |
| GO:0016020 | membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PEROXISOME | 78 | 47 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP | 368 | 234 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE DN | 485 | 334 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 4 5WK DN | 196 | 131 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER DN | 203 | 134 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| YAGI AML SURVIVAL | 129 | 87 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
| KEEN RESPONSE TO ROSIGLITAZONE UP | 38 | 23 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER DN | 134 | 83 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN | 116 | 74 | All SZGR 2.0 genes in this pathway |
| KASLER HDAC7 TARGETS 1 UP | 194 | 133 | All SZGR 2.0 genes in this pathway |
| YANG BCL3 TARGETS UP | 364 | 236 | All SZGR 2.0 genes in this pathway |