Gene Page: PEX6

Summary
GeneID  5190
Symbol  PEX6
Synonyms  PAF-2|PAF2|PXAAA1
Description  peroxisomal biogenesis factor 6
See related  HGNC:8859|MIM:601498|Ensembl:ENSG00000124587|HPRD:03293|
Locus tag  -
Gene type  protein-coding
Map location  6p21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingIMP16854980 
GO:0008022protein C-terminus bindingIPI16854980 
GO:0017111nucleoside-triphosphatase activityIEA-
GO:0032403protein complex bindingIDA16854980 
GO:0042623ATPase activity, coupledIMP16854980 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006625protein targeting to peroxisomeIMP16854980 
GO:0016561protein import into peroxisome matrix, translocationIMP8670792 
GO:0050821protein stabilizationIMP8670792 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIDA16854980 
GO:0005737cytoplasmIDA8670792 
GO:0005777peroxisomeIDA11439091 |16854980 
GO:0005778peroxisomal membraneIEA-
GO:0016020membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PEX1ZWS1peroxisomal biogenesis factor 1-HPRD,BioGRID9588209 |9671729 
PEX26FLJ20695 | PEX26M1T | Pex26pM1Tperoxisomal biogenesis factor 26-HPRD,BioGRID12717447 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3Smad3 interacts with Pex6. This interaction is modeled on demonstrated interaction between human Smad3 and mouse Pex6.BIND14651998 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PEROXISOME 7847All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
YAGI_AML_SURVIVAL 12987All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_UP 3823All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_DN 11674All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway


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